Chemotherapy for Lung Cancer Patients

Uramoto, Hidetaka; Kagami, Seiji; Iwashige, Atsushi; Tsukada, Junichi

doi:10.7888/juoeh.28.75

Cited by 2 publications

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“…In conclusion, because amrubicin treatment has been shown to sometimes induce a response in small cell carcinoma, 3 it may be an effective candidate for the fi rst induction of chemotherapy in small cell carcinoma of the prostate, with careful management of any side effects that occur.…”

Section: Discussionmentioning

confidence: 99%

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Small cell carcinoma of the prostate treated with amrubicin

et al. 2008

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We describe the use of amrubicin hydrochloride to treat small cell carcinoma of the prostate in a 23-year-old man. Initial radiological examinations of the patient revealed a pelvic tumor associated with bilateral hydronephrosis, pelvic lymph node swelling, and lumbar vertebral bone metastases. The pathological diagnosis was small cell carcinoma originating in the prostate, based on positive immunohistochemical staining for neuron-specific enolase, synaptophysin, and myoglobulin; and negative staining for CD3e, CD20, leukocyte common antigen, and CD99. The clinical stage was T4N1M1. A bilateral nephrostomy was performed to improve renal function, and an ileostomy was established to prevent ileus. The first induction chemotherapy consisted of amrubicin 35 mg/m(2) (days 1, 2, 3, monthly). The amrubicin regimen caused a dramatic reduction in tumor size, but could not be continued, because of the occurrence of grade 4 diarrhea. A different regimen was then administered, consisting of one cycle of a 50% dose and a second cycle of a 75% dose of etoposide (100 mg/m(2) days 1, 2, 3), coadministered with carboplatin (AUC 5, plasma concentration curve). Five months after the induction of chemotherapy, the patient suffered respiratory arrest and died.

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Section: Discussionmentioning

confidence: 99%

“…2 There has been a recent report of the use of amrubicin hydrochloride, a synthetic 9-aminoanthracycline, as an agent against advanced small cell carcinoma of the lung. 3 We report here on the fi rst known case of small cell carcinoma originating in the prostate to be treated with amrubicin.…”

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Small cell carcinoma of the prostate treated with amrubicin

et al. 2008

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An optimized 3-step strategy for preventing and treating post-operation relapse and metastasis of malignant tumors with traditional Chinese medicine

Zheng²

2007

J Chin Integr Med

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Relapse and metastasis are the main causes responsible for failure of surgical operation in treating malignant tumors. This article introduces the present development in post-operation treatment of lung cancer, liver cancer and stomach cancer, showing that the synthetic treatment by stages combined with traditional Chinese medicine is the important way to prevent and treat the post-operation relapse and metastasis of tumors, and suggesting the optimized method for treatment.

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Chemotherapy for Lung Cancer Patients

Cited by 2 publications

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Small cell carcinoma of the prostate treated with amrubicin

Small cell carcinoma of the prostate treated with amrubicin

An optimized 3-step strategy for preventing and treating post-operation relapse and metastasis of malignant tumors with traditional Chinese medicine

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