Chemotherapy for treating high-grade osteosarcoma in children and young adults

Sirichativapee, Winai; Wisanuyotin, Taweechok; Pattanittum, Porjai; Paholpak, Permsak; Laupattarakasem, Pat; Srisodaphol, Wuttichai; Tsuchiya, Hiroyuki; Laopaiboon, Malinee; Kosuwon, Weerachai; Wiangnon, Surapon

doi:10.1002/14651858.cd012372

Cited by 2 publications

(1 citation statement)

References 63 publications

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“…Additionally, no survival advantage to amputation over limb-salvage procedures was found in a large retrospective studies presented by Simon et al (1986) and Gherlinzoni et al (1992) [10,11]. Given this fact, the limb salvage surgery is more frequently suggested, especially when proper surgical margins can be achieved [12,13,14]. Primary chemotherapeutics used for the treatment of osteosarcoma are: adriamycin (ADM), cisplatin (DDP), high-dose methotrexate (HD-MTX), ifosfamide (IFO) and epirubicin (EPI) [15].…”

Section: Introductionmentioning

confidence: 99%

The Potential Selective Cytotoxicity of Poly (L- Lactic Acid)-Based Scaffolds Functionalized with Nanohydroxyapatite and Europium (III) Ions toward Osteosarcoma Cells

et al. 2019

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Osteosarcoma (OSA) is malignant bone tumor, occurring in children and adults, characterized by poor prognosis. Despite advances in chemotherapy and surgical techniques, the survival of osteosarcoma patients is not improving significantly. Currently, great efforts are taken to identify novel selective strategies, distinguishing between cancer and normal cells. This includes development of biomimetic scaffolds with anticancer properties that can simultaneously support and modulate proper regeneration of bone tissue. In this study cytotoxicity of scaffolds composed from poly (L-lactic acid) functionalized with nanohydroxyapatite (nHAp) and doped with europium (III) ions—10 wt % 3 mol % Eu3+: nHAp@PLLA was tested using human osteosarcoma cells: U-2 OS, Saos-2 and MG-63. Human adipose tissue-derived stromal cells (HuASCs) were used as non-transformed cells to determine the selective cytotoxicity of the carrier. Analysis included evaluation of cells morphology (confocal/scanning electron microscopy (SEM)), metabolic activity and apoptosis profile in cultures on the scaffolds. Results obtained indicated on high cytotoxicity of scaffolds toward all OSA cell lines, associated with a decrease of cells’ viability, deterioration of metabolic activity and activation of apoptotic factors determined at mRNA and miRNA levels. Simultaneously, the biomaterials did not affect HuASCs’ viability and proliferation rate. Obtained scaffolds showed a bioimaging function, due to functionalization with luminescent europium ions, and thus may find application in theranostics treatment of OSA.

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Section: Introductionmentioning

confidence: 99%

The Potential Selective Cytotoxicity of Poly (L- Lactic Acid)-Based Scaffolds Functionalized with Nanohydroxyapatite and Europium (III) Ions toward Osteosarcoma Cells

et al. 2019

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Combination Therapy of Cisplatin and other Agents for Osteosarcoma: A Review

Kasiram

Hapidin

Abdullah

et al. 2021

CCTR

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Background: Osteosarcoma is the most common type of primary bone tumor in children and adolescents, which is associated with rapid progression and poor prognosis. Multimodal therapy is the most common approach utilized for osteosarcoma management, such as the application of chemotherapy in combination with surgery or radiation therapy. Cisplatin is one of the predominantly used chemotherapeutic agents for osteosarcoma. Optimally, it is employed in combination with other chemotherapeutic drugs along with surgery or radiation therapy. Despite the availability of numerous treatment approaches, patient survival rate has not definitively improved over the past three decades. Methods: We summarized all findings regarding the combination of cisplatin with other chemotherapeutic agents as well as with phytochemical compounds. Results: A combination of cisplatin with phytochemical compound synergistically enhances the killing effect of cisplatin on osteosarcoma cells with fewer side effects compared to combination with other chemotherapeutic agents. Conclusion: Conclusively, a combination of cisplatin with selected chemotherapeutic drugs, has been shown to be effective. However, the unchanged survival rate urges for the search of a new combination regimen. As a collaborative effort to substantiate the therapeutic efficacy, the combination with phytochemical compounds shows a promising response both in vitro as well as in the preclinical study.

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Chemotherapy for treating high-grade osteosarcoma in children and young adults

Cited by 2 publications

References 63 publications

The Potential Selective Cytotoxicity of Poly (L- Lactic Acid)-Based Scaffolds Functionalized with Nanohydroxyapatite and Europium (III) Ions toward Osteosarcoma Cells

The Potential Selective Cytotoxicity of Poly (L- Lactic Acid)-Based Scaffolds Functionalized with Nanohydroxyapatite and Europium (III) Ions toward Osteosarcoma Cells

Combination Therapy of Cisplatin and other Agents for Osteosarcoma: A Review

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