Chemotherapy for Treatment of Choroidal Metastases from Breast Carcinoma

Letson, Alan D.; Davidorf, Frederick H.; Bruce, Robert A.

doi:10.1016/0002-9394(82)90707-3

Cited by 59 publications

(34 citation statements)

References 6 publications

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“…There are however only anecdotal reports of patients with breast cancer who responded completely to multi-drug chemotherapy regimens administered for widespread metastatic disease [2,7]. Logani et al re-…”

Section: Discussionmentioning

confidence: 96%

“…Traditionally, choroidal metastases have been managed with othovoltage radiotherapy and stereotactic radiosurgery yielding an overall response rate of 70-80% in the eye, associated with improvement in visual acuity [2,5,6]. There are however only anecdotal reports of patients with breast cancer who responded completely to multi-drug chemotherapy regimens administered for widespread metastatic disease [2,7].…”

Section: Discussionmentioning

confidence: 99%

“…RT, moreover, prevents blindness [1]. Chemotherapy has been anecdotally reported to be as effective as radiotherapy for choroidal metastases [2]. Newer chemotherapeutic agents, such as taxanes (paclitaxel and docetaxel) have proven efficacy in pre-treated or chemotherapy naive patients with metastatic breast cancer [3].…”

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confidence: 99%

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Complete regression of choroidal metastases from breast cancer after docetaxel-based systemic chemotherapy

Kosmas

Malamos

Antonopoulos

2000

Med. Pediatr. Oncol.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Complete regression of choroidal metastases from breast cancer after docetaxel-based systemic chemotherapy

Kosmas

Malamos

Antonopoulos

2000

Med. Pediatr. Oncol.

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“…The effectiveness of chemotherapy as a single modality in treating choroidal metastasis is not widely reported in the literature, however; a study in patients with breast cancer and choroidal metastasis concluded that systemic chemotherapy is as effective as radiotherapy as all six patients treated with systemic chemotherapy alone showed regression of their choroidal metastasis (Letson et al, 1982). Additionally, of the 30 reported cases we reviewed, 14 patients were treated with chemotherapy without additional EBRT, it was worthy to notice that 6 out of the 14 patients had complete resolution, and additional 4 patients had partial regression of the choroidal metastasis.…”

Section: Discussionmentioning

confidence: 99%

Choroidal metastases as the sole initial presentation of metastatic lung cancer: Case report and review of literature

et al. 2012

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Background: Choroidal metastasis as an initial presenting feature of metastatic lung cancer is exceedingly rare. External beam radiotherapy (EBRT) is an effective and widely accepted therapeutic modality. However, data addressing the effectiveness of other treatment strategies is limited. Herein, we present a patient with choroidal metastases secondary to lung cancer and review the relevant literature.Case report: A 25-year-old male presented with deterioration of vision. His evaluation revealed bilateral choroidal metastasis secondary to adenocarcinoma of the lung. Unfortunately, his vision continued to deteriorate despite treatment with EBRT and chemotherapy. Conclusion:Metastatic lung cancer can manifest with choroidal metastasis as an initial presentation. Key

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“…The optimal therapy for asymptomatic choroidal metastases is unknown. Alternatively, a careful 'watchful waiting' strategy as well as a chemotherapy in patients with breast cancer seems reasonable [7,30]. We have irradiated a total of 14 eyes with asymptomatic metastases.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy of Choroidal Metastases in Patients with Disseminated Cancer

Bottke

Wiegel²,

Kreusel³

et al. 2000

Oncol Res Treat

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Background: >Choroidal metastasis is the most common ocular tumor, in most cases related to breast and lung cancer. Radiotherapy (RT) mostly is the therapy of choice. However, there is a lack of data about the results of uniformly, prospective treated patients. Patients and Methods: Between November 1994 and September 1997, 37 patients with 49 metastatic eyes were enrolled into the study. 25 patients (68%) had unilateral and 12 patients (32%) had bilateral metastases. 21 patients had breast cancer as primary tumor, 12 patients lung cancer, and 4 patients other tumors. 3 patients were excluded from analysis, 34 patients with 46 involved eyes were available for analysis. 29 of those patients had symptomatic metastases, 5 patients had asymptomatic choroidal metastases. RT was performed with bi- or unilateral asymmetric fields, total dose was 40 Gy with a single dose of 2 Gy, 5 fractions per week. 12 patients (35%) had a chemotherapy following RT due to diagnosis of general tumor progression. Endpoints of the study were visual acuity (VA), local tumor control, survival, and side effects. Results: The median follow up was 6 months, 22 out of 34 patients died of metastatic disease. In 17 of symptomatic eyes (53%) an increase of VA and in 11 of symptomatic eyes (34%) a ‘no change’ was achieved. The local tumor control rate after 18 months was 83%. One patient with asymptomatic metastasis (1/14 eyes) developed symptoms until death. The median survival time was 15 months. Altogether, in 2 patients late side effects (6%) were observed (1 patients with bilateral retinopathy, 1 patient with optic nerve atrophy). Conclusions: RT with 40 Gy is highly effective in the treatment of symptomatic and asymptomatic choroidal metastases, VA was stable or improved in almost 90% of treated eyes. The rate of side effects is low.

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Chemotherapy for Treatment of Choroidal Metastases from Breast Carcinoma

Cited by 59 publications

References 6 publications

Complete regression of choroidal metastases from breast cancer after docetaxel-based systemic chemotherapy

Complete regression of choroidal metastases from breast cancer after docetaxel-based systemic chemotherapy

Choroidal metastases as the sole initial presentation of metastatic lung cancer: Case report and review of literature

Radiotherapy of Choroidal Metastases in Patients with Disseminated Cancer

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