Chemotherapy–Induced Colitis

Barcenas, Carlos H.; Ibrahim, Nuhad K.

doi:10.5772/28125

Cited by 1 publication

(1 citation statement)

References 61 publications

(87 reference statements)

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“…While several cases of capecitabine-induced colitis have been reported in the literature, only two cases have shown an association between capecitabine and IBD [2] . The precise pathogenesis of chemotherapy-induced colitis remains unclear but could involve mucosal injury caused by direct chemotherapy toxicity, weakened host defense against intestinal microorganisms, or microvascular disruption [3] . Additionally, there have been reports of severe ischemic colitis following chemotherapy with cisplatin and capecitabine, with an association found between arterial thrombosis of mesenteric blood vessels and the development of colitis [4] .…”

Section: Discussionmentioning

confidence: 99%

Challenging Case: A Case Report on Crohn's Disease Emerging after The Initiation of Capecitabine for Colorectal Cancer

2024

The Egyptian Journal of Hospital Medicine

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Background: Inflammatory bowel disease (IBD) is a chronic inflammatory condition that affects the gastrointestinal tract. This group of disorders includes Crohn's disease and ulcerative colitis. Diagnosis of IBD involves a comprehensive approach that combines medical history, physical examination, laboratory tests, endoscopy, imaging, and occasionally biopsy of intestinal tissue. Patients with IBD have an increased risk of developing colorectal adenocarcinoma, a type of colorectal cancer. However, IBD induced by surgical resections of the intestines or chemotherapy drugs is extremely rare.Objective: This study aimed to throw the light on the importance of careful evaluation and accurate diagnosis in patients presenting with symptoms suggestive of both types of IBD. Subject and methods: This abstract presents a challenging case in which a patient was initially suspected to have chemotherapy-induced colitis but was ultimately diagnosed with IBD-associated colorectal cancer. Results:The case highlighted the importance of careful evaluation and accurate diagnosis in patients presenting with symptoms suggestive of both IBD, as the treatment approaches and prognoses can significantly differ between the two conditions. Conclusion: Capecitabine, commonly used in cancer treatment, can induce colitis with symptoms that overlap with those of inflammatory bowel disease (IBD). Distinguishing between capecitabine-induced colitis and IBD is challenging due to similar clinical presentations. Discontinuation of capecitabine often leads to symptom improvement, but in IBD cases, additional therapies like steroids and biologics may be necessary. Close monitoring and further evaluation are crucial for accurate diagnosis and appropriate treatment strategies in patients experiencing gastrointestinal toxicity from capecitabinebased chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Challenging Case: A Case Report on Crohn's Disease Emerging after The Initiation of Capecitabine for Colorectal Cancer

2024

The Egyptian Journal of Hospital Medicine

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Chemotherapy–Induced Colitis

Cited by 1 publication

References 61 publications

Challenging Case: A Case Report on Crohn's Disease Emerging after The Initiation of Capecitabine for Colorectal Cancer

Challenging Case: A Case Report on Crohn's Disease Emerging after The Initiation of Capecitabine for Colorectal Cancer

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