Chemotherapy-Induced Long Non-coding RNA 1 Promotes Metastasis and Chemo-Resistance of TSCC via the Wnt/β-Catenin Signaling Pathway

Lin, Zhaoyu; Sun, Lijuan; Xie, Shuhua; Zhang, Shanyi; Fan, ST; Li, Qunxing; Chen, Weixiong; Pan, Guokai; Wang, Weiwei; Weng, Bin; Zhang, Zhang; Liu, Bodu; Li, Jinsong

doi:10.1016/j.ymthe.2018.04.002

Cited by 54 publications

(30 citation statements)

References 38 publications

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“…10,11 For example, lncRNAs HOTAIR, CYTOR, and SNHG14 participate in the metastatic cascade by regulating cell migration and invasion, [12][13][14] and lncRNAs ATB and CILA1 promote metastasis by inducing the epithelial-mesenchymal transition (EMT). 15,16 Our recent study discovered that lncRNA LBCS inhibits self-renewal and chemoresistance of BCa stem cells through the epigenetic silencing of SOX2. 17 Our previous study found that lncRNA BLACAT2 promoted BCa-associated lymphangiogenesis and lymphatic metastasis by enhancing vascular endothelial growth factor C (VEGF-C) signaling.…”

Section: Introductionmentioning

confidence: 99%

DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression

et al. 2019

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The prognosis for patients with bladder cancer (BCa) with lymph node (LN) metastasis is poor, and it is not improved by current treatments. Long noncoding RNAs (lncRNAs) are involved in the pathology of various tumors, including BCa. However, the role of Differentiation antagonizing non-protein coding RNA (DANCR) in BCa LN metastasis remains unclear. In this study, we discover that DANCR was significantly upregulated in BCa tissues and cases with LN metastasis. DANCR expression was positively correlated with LN metastasis status, tumor stage, histological grade, and poor patient prognosis. Functional assays demonstrated that DANCR promoted BCa cell migration, invasion, and proliferation in vitro and enhanced tumor LN metastasis and growth in vivo. Mechanistic investigations revealed that DANCR activated IL-11-STAT3 signaling and increased cyclin D1 and PLAU expression via guiding leucine-rich pentatricopeptide repeat containing (LRPPRC) to stabilize mRNA. Moreover, oncogenesis facilitated by DANCR was attenuated by anti-IL-11 antibody or a STAT3 inhibitor (BP-1-102). In conclusion, our findings indicate that DANCR induces BCa LN metastasis and proliferation via an LRPPRC-mediated mRNA stabilization mechanism. DANCR may serve as a multi-potency target for clinical intervention in LN-metastatic BCa.

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Section: Introductionmentioning

confidence: 99%

DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression

et al. 2019

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“…At present, it has been found that many lncRNAs can be used as markers of TSCC. For example, lncRNA CILA1 could serve as a biomarker for the chemo-sensitivity of TSCC tumors [33] and LINC00152 could function as a biomarker for the early detection and prognosis prediction of TSCC [34]. Therefore, continuous exploration of lncRNA function might provide a more theoret ical basis for TSCC treatment.…”

Section: Tsccmentioning

confidence: 99%

Long noncoding RNA UCA1 regulates CCR7 expression to promote tongue squamous cell carcinoma progression by sponging miR-138-5p

Shi¹,

Li²,

Zhao³

2021

neo

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Tongue squamous cell carcinoma (TSCC) is a malignant tumor. Long non-coding RNAs (lncRNAs) have been proved to be involved in the regulation of the progression of various cancers. However, the mechanism of lncRNA urothelial cancer-associated 1 (UCA1) in the progression of TSCC remains unclear. The expression levels of UCA1, microRNA-138-5p (miR-138-5p), and CC chemokine receptor 7 (CCR7) were measured by quantitative real-time polymerase chain reaction (qRT-PCR). The proliferation, migration and invasion were detected using colony formation assay and transwell assay, respectively. Western blot (WB) analysis was used to test the levels of proliferation and metastasis-related proteins and CCR7 protein. Moreover, the extracellular acidification rate (ECAR) of cells was measured by the Seahorse XF Extracellular Flux Analyzer, and the adenosine triphosphate (ATP) level, glucose uptake, and lactate produce of cells were tested by their corresponding assay kits. Further, the dual-luciferase reporter assay was used to confirm the interaction between miR-138-5p and UCA1 or CCR7. In addition, the effect of UCA1 on TSCC tumor growth in vivo was evaluated by animal experiments. We found that UCA1 and CCR7 were upregulated, while miR-138-5p was downregulated in TSCC tissues. Silenced UCA1 restrained the proliferation, migration, invasion, and glycolysis metabolism of TSCC cells. Similarly, knockdown of CCR7 also could suppress the progression of TSCC. Besides, UCA1 overexpression promoted TSCC progression, while this promotion effect could be reversed by CCR7 silencing. miR-138-5p could be sponged by UCA1 and could target CCR7. Additionally, miR-138-5p overexpression could reverse the promotion effect of overexpressed UCA1 on TSCC progression. Furthermore, the UCA1 knockdown reduced TSCC tumor growth in vivo. In conclusion, lncRNA UCA1 might function as an oncogene in TSCC through regulating the miR-138-5p/CCR7 axis, providing a new biomarker for TSCC treatment.

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“… 7 , 8 , 9 In recent years, with the deepening of cancer research, the mutation of non-coding genes, the change of epigenetic structures, and the change of genome structures can drive the generation of tumors. 10 , 11 , 12 , 13 From the point of view of gene expression and the regulation process, the gene expression and regulation of tumor cells are different from those of normal cells, so that they have the ability of infinite proliferation, even invasion and metastasis. 14 …”

Section: Main Textmentioning

confidence: 99%

Targeting Long Non-coding RNA to Therapeutically Regulate Gene Expression in Cancer

Shi

Liu

et al. 2020

Molecular Therapy - Nucleic Acids

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Long-chain non-coding RNAs (lncRNAs) are RNA molecules with a length greater than 200 nt and no function of encoding proteins. lncRNAs play a precise regulatory function at different levels of transcription and post-transcription, and they interact with various regulatory factors to regulate gene expression, and then participate in cell growth, differentiation, apoptosis, and other life processes. In recent years, studies have shown that the abnormal expression of lncRNAs is closely related to the occurrence and development of tumors, which is expected to become an effective biomarker in tumor diagnosis. The sequencing analysis of mutations in the whole tumor genome suggests that mutations in non-coding regions may play an important role in the occurrence and development of tumors. Therefore, in-depth study of lncRNAs is helpful to clarify the molecular mechanism of tumor occurrence and development and to provide new targets for tumor diagnosis and treatment. This review introduces the molecular mechanism and clinical application prospect of lncRNAs affecting tumor development from the perspective of gene expression and regulation.

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Chemotherapy-Induced Long Non-coding RNA 1 Promotes Metastasis and Chemo-Resistance of TSCC via the Wnt/β-Catenin Signaling Pathway

Cited by 54 publications

References 38 publications

DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression

DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression

Long noncoding RNA UCA1 regulates CCR7 expression to promote tongue squamous cell carcinoma progression by sponging miR-138-5p

Targeting Long Non-coding RNA to Therapeutically Regulate Gene Expression in Cancer

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