Chemotherapy-induced nausea and vomiting control in pediatric patients receiving ifosfamide plus etoposide: a prospective, observational study

Patel, Priya; Lavoratore, Sara R; Flank, Jacqueline; Kemp, Meaghan; Vennettilli, Ashlee; Vol, Helen; Taylor, Tracey; Zelunka, Elyse; Maloney, Anne Marie; Nathan, Paul C.; Dupuis, L. Lee

doi:10.1007/s00520-019-04903-0

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…Similar to what has been reported in other studies evaluating nausea severity in children using a validated tool (Patel et al, 2020;Dupuis, Kelly et al, 2018;Flank, Sparavalo et al, 2017;Flank, Nadeem et al, 2017), nausea was not well controlled in our patients. To fully optimize CINV control, specific antinauseant agents may be required in addition to antiemetic agents given to prevent chemotherapy-induced vomiting.…”

Section: Discussionsupporting

confidence: 90%

“…Clinical practice guideline-consistent antiemetic agents are effective at preventing chemotherapy-induced vomiting (Hesketh et al, 2015;Patel et al, 2017;Gilmore et al, 2014). However, they are less effective at controlling nausea (Vol et al, 2016;Patel et al, 2020;Sparavalo, et al, 2012). Validated instruments to assess nausea severity are needed to determine the effectiveness of antinauseant interventions in pediatric patients.…”

Section: Discussionmentioning

confidence: 99%

“…The English-language PeNAT is reliable and valid (Dupuis et al, 2006). It has been used to describe the burden of nausea in children receiving various chemotherapies (Vol et al, 2016;Patel et al, 2020;Clinton et al, 2012), to evaluate the efficacy of antinauseant interventions (Dupuis et al, 2018;Evans et al, 2018) and to assess nausea severity as part of routine clinical care (McKinnon & Jupp, 2019). However, its use is restricted to English-speaking patients.…”

Section: Introductionmentioning

confidence: 99%

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The Pediatric Nausea Assessment Tool: French translation and face validity in Francophone-Canadian pediatric oncology patients

Choquette¹,

Sivananthan²,

Guillemette³

et al. 2021

CONJ

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Chemotherapy-induced nausea and vomiting (CINV) continue to negatively influence the quality of life of both adult and pediatric cancer patients (Dupuis et al., 2010; Farrell et al., 2013; Russo et al., 2014; Hinds et al., 2009; Sommariva et al., 2016). Vomiting and retching are symptoms that can be assessed objectively while nausea, a subjective symptom, is more difficult to quantify. Adult cancer patients can usually describe the severity of the nausea they feel using self-report visual analog or adjectival rating scales. Instruments such as the Multinational Association of Supportive Care in Cancer Antiemesis Tool (available from www.mascc.org) have been validated for this purpose and are recommended by experts in the field (Hesketh et al., 2015).

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Pediatric Nausea Assessment Tool: French translation and face validity in Francophone-Canadian pediatric oncology patients

Choquette¹,

Sivananthan²,

Guillemette³

et al. 2021

CONJ

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“…Les antiémétiques recommandés dans les lignes directrices de la pratique clinique sont efficaces pour prévenir les vomissements induits par la chimiothérapie (Hesketh, Bohlke, Lyman et al, 2015;Patel, Robinson, Thackry et al, 2017;Gilmore, Peacock, Gu et al, 2014). Cependant, ils sont moins efficaces pour soulager les nausées (Vol et al, 2016;Patel, Lavoratore et al, 2020;Sparavalo, Hagen, Chong et al, 2012). Nous avons besoin d'outils validés pour évaluer l'intensité des nausées et ainsi déterminer l'efficacité des interventions visant à soulager les nausées et les vomissements chez les patients en pédiatrie.…”

Section: Discussionunclassified

Instrument de mesure de la nausée chez l’enfant : traduction française et validité des visages pour les patients canadiens francophones en oncopédiatrie

Choquette¹,

Sivananthan²,

Guillemette³

et al. 2021

CONJ

Self Cite

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Les nausées et les vomissements induits par la chimiothérapie (NVIC) nuisent à la qualité de vie tant des adultes que des patients pédiatriques atteints d’un cancer (Dupuis, Milne-Wren, Cassidy et al., 2010; Farrell, Brearley, Pilling et Molassiotic, 2013; Russo, Cinausero, Gerratana et al., 2014; Hinds, Gattuso, Billups et al., 2009; Sommariva, Pongiglione, et Tarricone, 2016). Les vomissements et les haut-le-cœur sont des symptômes qui s’évaluent objectivement, alors que la nausée est subjective et plus difficile à mesurer. En général, l’intensité de la nausée chez les adultes peut être décrite à l’aide d’échelles d’évaluation visuelle analogique ou qualitative. Il existe à cette fin des instruments validés et recommandés par des spécialistes du domaine, comme celui de la Multinational Association of Supportive Care in Cancer (en ligne : www.mascc.org) (Hesketh, Gralla, du Bois et Tonato, 2016).

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“…This phenomenon triggers mutagenic and cell death pathways. The function of topoisomerase II is understood in some detail, as is the mechanism of inhibition of etoposide at a molecular level ( 34 ). Etoposide has some shortcomings, including limited neoplastic activity against several solid tumors, including non-small cell lung cancer, cross-resistance to multidrug-resistant tumor cell lines, and low bioavailability ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of potential biomarkers and available drugs for oral squamous cell carcinoma

Zhang¹,

Bi²,

Zhang³

et al. 2021

Transl Cancer Res TCR

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Background: Oral squamous cell carcinoma (OSCC) is the most common oral tumor globally. However, optimal therapeutic targets for OSCC have not been identified. This study aimed to identify the potential gene markers and available drugs for OSCC.Methods: Two transcriptional datasets containing OSCC gene expression data (GSE30784 and GSE23558) were selected from the Gene Expression Omnibus database. The interactive web tool GEO2R was then used to analyze the differentially expressed genes (DEGs) analysis. A Venn diagram was used to integrate the DEGs screened out by the two microarrays. Subsequently, a protein-protein interaction (PPI) network analysis of DEGs was performed using the Cytoscape, Database for Annotation, Visualization and Intergrated Discovery, and STRING databases. In addition to constructing the PPI networks among these DEGs, we chose several significant gene modules to conduct further gene-drug interaction analyses. Lastly, the existing drugs that target these module genes were selected to explore their therapeutic efficacy in treating OSCC.Results: A total of 199 DEGs were screened out by the two microarrays. They were found to be associated with several processes, including the epoxygenase P450 pathway and the organelle membrane. The significant module genes in the PPI networks were CYP2E1, SCEL, KRT4, and KRT19. One existing drug, etoposide, which targets the CYP2E1 gene, was acquired.Conclusions: Four potential biomarkers (CYP2E1, SCEL, KRT4, and KRT19) and one existing drug (etoposide) were obtained for gene expression prediction through a series of bioinformatics methods.

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Chemotherapy-induced nausea and vomiting control in pediatric patients receiving ifosfamide plus etoposide: a prospective, observational study

Cited by 8 publications

References 18 publications

The Pediatric Nausea Assessment Tool: French translation and face validity in Francophone-Canadian pediatric oncology patients

The Pediatric Nausea Assessment Tool: French translation and face validity in Francophone-Canadian pediatric oncology patients

Instrument de mesure de la nausée chez l’enfant : traduction française et validité des visages pour les patients canadiens francophones en oncopédiatrie

Identification of potential biomarkers and available drugs for oral squamous cell carcinoma

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