Chemotherapy-induced peripheral neuropathy: clinical features, diagnosis, prevention and treatment strategies

Gutiérrez-Gutiérrez, Gerardo; Sereno, María; Miralles, Ambrosio; Casado-Sáenz, Enrique; Gutiérrez-Rivas, Eduardo

doi:10.1007/s12094-010-0474-z

Cited by 153 publications

(120 citation statements)

References 67 publications

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“…Diferentemente do Sistema Nervoso Central, o Sistema Nervoso Periférico não é protegido pela barreira hematoencefálica e, isto o torna mais vulnerável aos efeitos das drogas neurotóxicas, como aos muitos agentes antineoplásicos (DÂNGELO & FATTINI, 2003;GUTIÉRREZ-GUTIÉRREZ et al, 2010).…”

Section: Neuropatia Periférica Induzida Pela Quimioterapia (Npiq)unclassified

“…A sobrevida global do paciente aumenta com o uso desta drogas, no entanto, eleva-se os efeitos adversos como a NPIQ que, atinge aproximadamente 30% a 40% dos pacientes submetidos ao tratamento antineoplásico com drogas neurotóxicas. Nas próximas décadas, estima-se que a prevalência da NPIQ irá aumentar (YAZDANI, ABDI, 2007;WINDEBANK, GRISOLD, 2008;MALIK, STILLMAN, 2008;GUTIÉRREZ-GUTIÉRREZ et al, 2010;LEMA, FOLEY, HAUSHEER, 2010;MILTENBURG, BOOGERD, 2014).…”

Section: Neuropatia Periférica Induzida Pela Quimioterapia (Npiq)unclassified

“…Muitos agentes quimioterápicos utilizados atualmente estão associados com o desenvolvimento da NPIQ, na qual pode afetar negativamente a terapia medicamentosa planejada e a qualidade de vida ao interferir nas atividades diárias do paciente (HAUSHEER, et al, 2006;GUTIÉRREZ-GUTIÉRREZ et al, 2010;GRIFFITH, et al, 2010;LEMA, FOLEY, HAUSHEER, 2010;MILTENBURG, BOOGERD, 2014).…”

Section: Neuropatia Periférica Induzida Pela Quimioterapia (Npiq)unclassified

“…E, em alguns casos sua cronificação pode acontecer e permanecer ao longo da vida (GUTIÉRREZ-GUTIÉRREZ et al, 2010). …”

Section: Neuropatia Periférica Induzida Pela Quimioterapia (Npiq)unclassified

“…Para a enfermagem, sua única intervenção recomendada para minimizar os efeitos da NPIQ são educação, orientação e apoio visando a segurança do paciente (VISOVSKY et al, 2007; MALIK, STILLMAN, 2008;GUTIÉRREZ-GUTIÉRREZ et al, 2010). A enfermagem desempenha um papel fundamental no cuidado aos pacientes em risco para NPIQ, incluindo a contínua avaliação precoce, durante e após o tratamento, a orientação ao paciente, a administração segura dos quimioterápicos, a manejo dos sintomas, as consultas oportunas com outros membros da equipe interdisciplinar.…”

Section: 7unclassified

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Adaptação transcultural e validação do instrumento <i>Chemotherapy-Induced Peripheral Neuropathy Assessment Tool</i> (CIPNAT) para o Brasil

Zandonai¹,

Sawada²

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Section: Neuropatia Periférica Induzida Pela Quimioterapia (Npiq)unclassified

“…E, em alguns casos sua cronificação pode acontecer e permanecer ao longo da vida (GUTIÉRREZ-GUTIÉRREZ et al, 2010). …”

Section: Neuropatia Periférica Induzida Pela Quimioterapia (Npiq)unclassified

Section: 7unclassified

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Adaptação transcultural e validação do instrumento <i>Chemotherapy-Induced Peripheral Neuropathy Assessment Tool</i> (CIPNAT) para o Brasil

Zandonai¹,

Sawada²

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Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer

Cao

Cartmel

et al. 2023

JAMA Netw Open

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ImportanceChemotherapy-induced peripheral neuropathy (CIPN), one of the most common and severe adverse effects of chemotherapy, is associated with worse quality of life among survivors of ovarian cancer. Currently, there is no effective treatment for CIPN.ObjectiveTo evaluate the effect of a 6-month aerobic exercise intervention vs attention-control on CIPN among women treated for ovarian cancer in the Women’s Activity and Lifestyle Study in Connecticut (WALC) to provide evidence to inform the guidelines and recommendations for prevention or treatment of CIPN.Design, Setting, and ParticipantsThis prespecified secondary analysis evaluated the Women’s Activity and Lifestyle Study in Connecticut (WALC), a multicentered, open-label, population-based, phase 3 randomized clinical trial of an aerobic exercise intervention vs attention control for CIPN in patients who were diagnosed with ovarian cancer. Only WALC participants who received chemotherapy were included in this analysis. Participants were randomized 1:1 to either a 6-month aerobic exercise intervention or to attention control. All analyses were conducted between September 2022 and January 2023.InterventionsThe exercise intervention consisted of home-based moderate-intensity aerobic exercise facilitated by weekly telephone counseling from an American College of Sports Medicine/American Cancer Society–certified cancer exercise trainer. Attention control involved weekly health education telephone calls from a WALC staff member.Main Outcomes and MeasureChange in CIPN was the primary outcome in this secondary analysis. This outcome was represented by CIPN severity, which was self-measured by participants at baseline and 6 months using the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group–Neurotoxicity scale, with a score range of 0 to 44. A mixed-effects model was used to assess the 6-month change in CIPN between the exercise intervention and attention control arms.ResultsOf the 134 participants (all females; mean [SD] age, 57.5 [8.3] years) included in the analysis, 69 were in the exercise intervention arm and 65 were in the attention control arm. The mean (SD) time since diagnosis was 1.7 (1.0) years. The mean (SD) baseline CIPN scores were 8.1 (5.6) in the exercise intervention arm and 8.8 (7.9) in the attention control arm (P = .56). At 6 months, the self-reported CIPN score was reduced by 1.3 (95% CI, −2.3 to −0.2) points in the exercise intervention arm compared with an increase of 0.4 (95% CI, −0.8 to 1.5) points in the attention control arm. The between-group difference was −1.6 (95% CI, −3.1 to −0.2) points. The point estimate was larger among the 127 patients with CIPN symptoms at enrollment (−2.0; 95% CI, −3.6 to −0.5 points).Conclusions and RelevanceFindings of this secondary analysis of the WALC trial indicate that a 6-month aerobic exercise intervention vs attention control significantly improved self-reported CIPN among patients who were treated for ovarian cancer. While replication of the findings in other studies is warranted, incorporating referrals to exercise programs into standard oncology care could reduce CIPN symptoms and increase quality of life in patients with ovarian cancer.Trial RegistrationClinicalTrials.gov Identifier: NCT02107066

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In Situ Piezoelectric‐Catalytic Anti‐Inflammation Promotes the Rehabilitation of Acute Spinal Cord Injury in Synergy

You,

Jiang,

Zheng

et al. 2024

Advanced Materials

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Relieving inflammation via scavenging toxic reactive oxygen species (ROS) during the acute phase of spinal cord injury (SCI) has been proved to be an effective strategy to mitigate secondary spinal cord injury and improve recovery of motor function. However, commonly used corticosteroid anti‐inflammatory drugs such as methylprednisolone show adverse side effects which may induce gastrointestinal bleeding, femoral head necrosis and an increased risk of wound infection. Fortunately, hydrogen (H2), featuring selective antioxidant performance, easy penetrability and excellent biosafety, is being extensively investigated as a potential anti‐inflammatory therapeutic gas for the treatment of SCI. In this work, by a facile in situ growth approach of gold nanoparticles (AuNPs) on the piezoelectric BaTiO3, a particulate nanocomposite with Schottky heterojunction (Au@BT) has been synthesized, which can generate H2 continuously by catalyzing H+ reduction through piezoelectric catalysis. Furthermore, theoretical calculations were employed to reveal the piezoelectric catalytic mechanism of Au@BT. Transcriptomics analysis and nontargeted large‐scale metabolomic analysis reveal that the deeper mechanism of the neuroprotective effect of H2 therapy based on Au@BT + US. The as‐prepared Au@BT nanoparticles have been first explored as a flexible hydrogen gas generator for efficient anti‐inflammatory and pro‐repair application for SCI therapy. This study highlights a promising prospect of nanocatalytic medicine for disease treatments by catalyzing H2 production, thus offering a significant alternative to conventional approaches against refractory spinal cord injury.This article is protected by copyright. All rights reserved

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Chemotherapy-induced peripheral neuropathy: clinical features, diagnosis, prevention and treatment strategies

Cited by 153 publications

References 67 publications

Adaptação transcultural e validação do instrumento <i>Chemotherapy-Induced Peripheral Neuropathy Assessment Tool</i> (CIPNAT) para o Brasil

Adaptação transcultural e validação do instrumento <i>Chemotherapy-Induced Peripheral Neuropathy Assessment Tool</i> (CIPNAT) para o Brasil

Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer

In Situ Piezoelectric‐Catalytic Anti‐Inflammation Promotes the Rehabilitation of Acute Spinal Cord Injury in Synergy

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