Chemotherapy-Induced Pulmonary Hypertension

Ranchoux, Benoît; Günther, Sven; Quarck, Rozenn; Chaumais, Marie-Camille; Dorfmüller, Peter; Antigny, Fabrice; Dumas, Sébastien J.; Raymond, Nicolas; Lau, Edmund; Savale, Laurent; Jaïs, Xavier; Sitbon, Olivier; Simonneau, Gérald; Stenmark, Kurt R.; Cohen‐Kaminsky, Sylvia; Humbert, Marc; Montani, David; Perros, Frédèric

doi:10.1016/j.ajpath.2014.10.021

Cited by 170 publications

(74 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[19]. Alkylating drugs, most frequently related to PVOD development included the following: cyclophosphamide, mitomycin C (MMC) and cisplatin, especially when combined with additional radiotherapy or allogenic steam cell transplantation [19]. The ability of cyclophosphamide to induce PH was confirmed by the authors in animal models [19].…”

Section: Occupational Dependence Of Pvod/pchmentioning

confidence: 80%

“…The questionnaire also revealed a significantly higher tobacco exposure in PVOD compared to PAH patients (total packyears 33 ± 24.7 vs 8.0 ± 14.3 respectively) [5]. [19]. Alkylating drugs, most frequently related to PVOD development included the following: cyclophosphamide, mitomycin C (MMC) and cisplatin, especially when combined with additional radiotherapy or allogenic steam cell transplantation [19].…”

Section: Occupational Dependence Of Pvod/pchmentioning

confidence: 99%

“…Alkylating drugs, most frequently related to PVOD development included the following: cyclophosphamide, mitomycin C (MMC) and cisplatin, especially when combined with additional radiotherapy or allogenic steam cell transplantation [19]. The ability of cyclophosphamide to induce PH was confirmed by the authors in animal models [19]. Subsequently, the same group of authors reported on 7 cases of chemotherapy-induced PVOD in patients with squamous cell anal carcinoma, who received MMC alone or in combination with 5-fluorouracil [20].…”

Section: Occupational Dependence Of Pvod/pchmentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary Veno-Occlusive Disease: Pathogenesis, Risk Factors, Clinical Features and Diagnostic Algorithm—State of the Art

Szturmowicz¹,

Kacprzak²,

Szołkowska³

et al. 2018

Advances in Respiratory Medicine

View full text Add to dashboard Cite

Pulmonary veno-occlusive disease (PVOD) and pulmonary capillary haemangiomatosis (PCH) are rare disorders, with the estimated prevalence of less than 1 case per million inhabitants. The vascular pathology in PVOD/PCH involves pre-septal and septal veins, alveolar capillaries and small pulmonary arteries. According to the ERS/ESC classification of pulmonary hypertension (PH) from 2015, PVOD/PCH have been included in the subgroup 1' of pulmonary arterial hypertension (PAH). Recent data indicate, however, the possibility of PVOD/PCH pathology in the patients diagnosed in the group 1. The problem may concern PAH associated with scleroderma, drug-induced PAH, PAH due to HIV infection and up to 10% of patients with idiopathic PAH (IPAH). Recently, bi-allelic EIF2AK4 mutations were found in the cases with heritable form of PVOD/PCH and in about 9% of sporadic cases. Moreover, an association between occupational exposure to organic solvents and PVOD/PCH was proved. The present review is an attempt to summarise the current data on pathogenesis, risk factors, clinical features and diagnostic algorithm for PVOD/PCH.

show abstract

Section: Occupational Dependence Of Pvod/pchmentioning

confidence: 80%

Section: Occupational Dependence Of Pvod/pchmentioning

confidence: 99%

Section: Occupational Dependence Of Pvod/pchmentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary Veno-Occlusive Disease: Pathogenesis, Risk Factors, Clinical Features and Diagnostic Algorithm—State of the Art

Szturmowicz¹,

Kacprzak²,

Szołkowska³

et al. 2018

Advances in Respiratory Medicine

View full text Add to dashboard Cite

show abstract

“…Multiple case reports have reported a link between chemotherapeutic agents and radiation therapy with PVOD 10,15 . A recent detailed study of chemotherapy-induced PH from the French PH network was reviewed 15 .…”

mentioning

confidence: 99%

“…A recent detailed study of chemotherapy-induced PH from the French PH network was reviewed 15 . This study found alkylating and alkylating-like agents represent a significant risk factor for the development of PVOD.…”

mentioning

confidence: 99%

Pulmonary Veno-occlusive Disease and Pulmonary Hypertension in Dogs

Stenmark

Krafsur

Tuder³

2016

Vet Pathol

View full text Add to dashboard Cite

The influence of chemotherapy on the right ventricle: did we forget something?

Tadić

Cuspidi

Hering

et al. 2017

Clinical Cardiology

View full text Add to dashboard Cite

Background A large number of chemotherapy‐induced cardiovascular complications were discovered in studies over the last several decades. The focus of the majority of these studies was left ventricular (LV) remodeling. The aim of this article was to provide a comprehensive overview of potential mechanisms of chemotherapy‐induced right ventricular (RV) remodeling and summarize clinical studies on this topic. Hypothesis Chemotherapy induces RV structural, functional, and mechanical changes. Methods We searched PubMed, MEDLINE, Ovid and Embase databases for studies published from January 1990 up to September 2016 in the English language using the following keyword “chemotherapy,” “heart,” “right ventricle,” “anthracyclines,” and “trastuzumab.” Results The existing research show that RV remodeling occurs simultaneously with LV remodeling, which is why RV remodeling should not be neglected in the overall cardiac assessment of patients treated with chemotherapy, and especially those protocols that involve anthracyclines and trastuzumab. Investigations showed that these agents could significantly impact RV structure, function, and mechanics. These medications induce fibrosis of the RV myocardium, RV dilatation, decline in RV systolic function, worsening of its diastolic function, and finally impairment of RV mechanics (strain). The mechanisms of chemotherapy‐induced RV remodeling are still not entirely clear, but it is considered that direct destructive influence of chemotherapy on myocardium, oxidative stress, endothelial dysfunction, and negative impact on pulmonary circulation could significantly contribute to RV impairment. Conclusions Chemotherapy induces the impairment of RV structure, function, and mechanics by different complex mechanisms.

show abstract

Chemotherapy-Induced Pulmonary Hypertension

Cited by 170 publications

References 46 publications

Pulmonary Veno-Occlusive Disease: Pathogenesis, Risk Factors, Clinical Features and Diagnostic Algorithm—State of the Art

Pulmonary Veno-Occlusive Disease: Pathogenesis, Risk Factors, Clinical Features and Diagnostic Algorithm—State of the Art

Pulmonary Veno-occlusive Disease and Pulmonary Hypertension in Dogs

The influence of chemotherapy on the right ventricle: did we forget something?

Contact Info

Product

Resources

About