Chemotherapy induced thrombocytopenia treated by four types of platelets concentrates

Nikolić, Ljubinka I.; Nedeljkovic, Ninoslav; Jelić, S.; Suvajdzic-Vukovic, Nada; Fillipović-Lješković, Ivana M.; Marković, Srđan Z.; Janković, Drina; Kastratović, Dragana A.

doi:10.5937/hpimj1503297n

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…However, the authors suggested that results should be carefully interpreted and that clinical and laboratory results of all patients should be monitored. In addition, they suggested that it is necessary improving the current therapy guidelines in order to enable platelet therapy application in the near future [24].…”

Section: The Role Played By Prp In Cancer Treatmentmentioning

confidence: 99%

What is the potential use of platelet-rich-plasma (PRP) in cancer treatment? A mini review

Luzo

Fávaro

Seabra

2020

Heliyon

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Platelet-rich-plasma (PRP) is an autologous human platelet concentrate extracted from plasma. PRP has been investigated in order to be used in many fields, with emphasis on the musculoskeletal field applied to sports injuries, as well as on other medical fields such as cardiac surgery, gynecology, pediatric surgery, urology, ophthalmology and plastic surgery. Cancer treatment is another important field where PRP should be investigated; thus, it is important validating PRP preparation protocols to be used in clinical research. Many protocols should be revised since, overall, most studies do not provide necessary information to allow them to be multiplied or replicated. The current review focuses on several topics about cancer, mainly on innovative studies about PRP use as a feasible therapeutic alternative to treat bladder cancer -a field where it could play a key role. Relevant aspects such as platelets' contribution to immune regulation and the supportive role they play in innate and adaptive immune functions are also addressed. Another important topic reviewed in the current study refers to inflammatory process regulation associated with cancer and thrombosis sites, which indicated that tumor-induced platelet activation could be used as an important therapeutic target in the future. New aspects concerning nitric oxide's ability to restrain platelet adhesion and aggregation in order to slow metastasis progress in cancer patients provide an important advantage in cancer treatment. Finally, the current review has pointed out perspectives and the main concerns about, and possibilities of, PRP use in cancer treatment.

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Section: The Role Played By Prp In Cancer Treatmentmentioning

confidence: 99%

What is the potential use of platelet-rich-plasma (PRP) in cancer treatment? A mini review

Luzo

Fávaro

Seabra

2020

Heliyon

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“…• PDGF receptor Platelet receptors active in the stabilization phase of platelet activity can be found in the membrane or reach platelet membrane from α granules during activation phrases like P-selectin, CD36, PEAR1, PECAM-1 and PGI 2 receptor [2,11,12,9]. …”

Section: Platelet Receptorsmentioning

confidence: 99%

“…Platelets engage in the processes of infl ammation, unspecifi c body's defense, reproduction and tumor biology shown in (Figure No. 1) [9,10].…”

Section: Introductionmentioning

confidence: 99%

Platelets (thrombocytes): The other recognized functions

Nikolić¹,

Vukovic-Suvajdzic²,

Bugarinovic³

et al. 2016

Hosp Pharm Int Multi J

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SUMMARYIntroduction: Platelets are smallest blood cells of discoid or round shape and are cytoplasmic fragments of megakaryocytes.Platelets consist of 3 types of granules: alpha granules, dense granules and lysosomes. Granule secretion releases coagulation factors, growth factors, cytokines, and a number of proteolytic enzymes.Platelets contain a number of receptors known as platelet agonists. Basic and most studied role of platelets is in hemostasis process. The aim of this paper is to point on platelet function unrelated to hemostasis. Matherials and methoods: Papers on other recognized functions of platelets were searched for in biomedical journals idexed in MEDLINE form 2004 to 2016. Topic: This paper studies less known platelet functions becoming subject of interest with the development of applied science. Platelets participate in infl ammation by releasing proinfl ammatory mediators (CD154, CD40L). Complement activation via Pselectin, platelet-generates immunomodulatory eff ect. CD40L accelerates releasing RANTES protein leading to intensifi ed activation of T-lymphocytes. During embryonic development, platelets allow blood and lymph vessels separation by activating CLE-2 receptor and ligand PDPN. Platelets alleviate migration and invasiveness of tumor cells, contribute to disease progression and development of metastases. Platelets affect maturation of follicles and oocytes and have important role in embryo implantation process and placentation. Conclusion: Based on these fi ndings, conclusion imposes platelets as not only active participants in the hemostasis process but as having signifi cant role in infl ammation, unspecifi ed and specifi ed body defending, tumor biology, embryonic development and in female reproductive system regulation. Numerous roles of platelets open wide range for the new drugs' operation. Their specifi c characteristic is the basis for the personalized Clinical pharmacology development and possibility of applying specifi c drug as polyindicative therapeutic agent.

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Chemotherapy induced thrombocytopenia treated by four types of platelets concentrates

Cited by 2 publications

References 24 publications

What is the potential use of platelet-rich-plasma (PRP) in cancer treatment? A mini review

What is the potential use of platelet-rich-plasma (PRP) in cancer treatment? A mini review

Platelets (thrombocytes): The other recognized functions

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