Chemotherapy of Lymphogranuloma Venereum with Sulfonamide Drugs

Jones, Helen; Rake, Geoffrey; McKee, Clara M.

doi:10.3181/00379727-48-13307

Cited by 21 publications

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“…Holder et at. (98) found that contact between a sulfonamide and the virus of lymphogranuloma venereum in vitro results in decreased virulence of the virus but no apparent virucidal action, an observation in accordance with observations in vivo (112).…”

Section: B Empirical Observations On the Action Of Sulfonamidessupporting

confidence: 62%

The Mode of Action of the Sulfonamides

Henry

1944

JAMA

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Section: B Empirical Observations On the Action Of Sulfonamidessupporting

confidence: 62%

The Mode of Action of the Sulfonamides

Henry

1944

JAMA

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“…In this connection it is of interest that while sulfanilamide and sulfamethyldiazine do protect mice infected with lymphogranuloma venereum they do not eradicate the virus. Jones, Rake and McKee (1941) recently reported that they were able to recover lymphogranuloma virus from mice which had been treated with sulfonamides. Similarly we have been able to recover the virus from mice which had received 6 months intensive sulfanilamide treatment and clinically appeared normal.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Para-Aminobenzoic Acid on the Chemotherapeutic Activity of the Sulfonamides in Lymphogranuloma Venereum and in Duck Malaria

1943

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It is now well established that para-aminobenzoic acid inhibits the action of sulfonamides on bacteria in vitro and in vivo . (Rubbo and Gillespie, 1940;Selbie, 1940;Woods, 1940). Wiedling (1941) found that para-aminobenzoic acid produced an inhibition of the effect of sulfanilamide, sulfapyridine and sulfathiazole on the fresh water diatom Nitzschia palea var. debilis. Experiments published by Dimond (1941) showed that para-aminobenzoic acid interfered with the action of sulfanilamide on the fungus Trichophyton purpureum. Findlay (1940) has reported that para-aminobenzoic acid inhibited the action of sulfanilamide on a strain of lymphogranuloma venereum.In this communication experiments will be reported which demonstrate the inhibiting effect of para-aminobenzoic acid on the chemotherapeutic activity of sulfamethyldiazine in Plasmnodium lophurae infections in Pekin ducklings. Experiments will also be presented in which, contrary to the experience of Findlay (1940), we were unable to show that para-aminobenzoic acid neutralized the action of sulfanilamide and sulfamethyldiazine on a strain of lymphogranuloma venereum. EXPERIMENTALIn two sets of experiments a total of thirty-eight Pekin ducklings weighing about 50 grams each were inoculated intravenously with 2,000,000 erythrocytes parasitized by P. lophurae.1 Twelve of the infected birds were given 200 mgm. per kgm. of para-aminobenzoic acid together with 200 mgm. per kgm. of sulfamethyldiazine. Eight birds received 200 mgm. per kgm. of para-aminobenzoic acid alone and six birds served as untreated controls. The drugs were incorporated in the food (Startena Mash) so that a reasonably constant blood level was maintained. Therapy was begun on the day of inoculation and continued for 10 days. Beginning on the fourth day following inoculation, the severity of the infection was followed by daily examination of the blood. The results are recorded in table 1. The course of the malaria in the birds receiving paraaminobenzoic acid alone did not differ from that seen in the untreated controls. As the table shows there was a striking difference between the course of the infection in the ducklings given sulfamethyldiazine alone and the course in the birds receiving the drug together with para-aminobenzoic acid. The ducklings receiving sulfamethyldiazine showed few parasites in the blood while those 1 We are indebted to Dr. L. T. Coggeshall for this parasite and for information concerning the technique of handling it in the laboratory. 205

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“…The mice either die rapidly or soon become ~vell. In fact limited experiments indicate that these mice, having received intravenously high concentrations of yolk sac material, which not merely is toxic but contains large numbers of viral bodies potentially infectious by other routes, do not become carriers, despite the relative ease with which the carrier state is set up in mice surviving infection (9,19). The agent is not demonstrable by the most sensitive methods of detection in the brain or spleen of mice surviving sublethal doses of toxin.…”

Section: The Toxin From the Agent Of Lymphogranuloma Venereummentioning

confidence: 99%

Studies on Lymphogranuloma Venereum

Rake

Jones

1944

Journal of Experimental Medicine

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The association of a toxin or toxic factor with a Virus has never been demonstrated although it may have been suspected. In fact, under most circumstances it is difficult to devise experiments which would demonstrate clearly the occurrence of a toxin in association with these agents since both would be of small size and usually of labile nature. Thus, ff all possible sources of confusion were controlled, a positive result would be of great value but a negative one would be without significance.For many reasons it has been suspected in this laboratory that the agent of lymphogranuloma venereum, and the other agents which have been shown to be closely allied to it (1-5) should be separated from the true viruses and established in a group by themselves, comparable to the R i c k e t t~ for example (6). It had also been suspected that the agent of lymphogranuloma venereum at least, with which we have had most experience, produces a toxin. In the acute form of generalized infection with this latter agent in man, chills, severe headache, and marked prostration occur and the whole picture suggests a toxemia (7,8). Furthermore, in the laboratory, the convulsive deaths occuring in mice within 30 hours after intracerebral infection (9) are difficult to account for by the lesions present in the meninges, and the cause of death in the chick embryo after infection of the yolk sac has always seemed due possibly to toxemia since the agent does not invade the embryo to any marked extent (10), and careful studies have shown that no significant disturbance of nutrition results from the infection of the yolk ceils (11).The work of Gildemeister and Haagen (12) on the toxin associated with Rickettsia mooseri grown in the yolk sac of the chick embryo stimulated anew our interest in this problem. These authors found that suspensions of yolk sacs heavily infected with R. mooseri, when suspended in Ringer's solution, were lethal for mice. Following intraperitoneal inoculation of 0.5 to 1.0 ml. of such suspensions the mice died in 4 to 48 hours, often with convulsions. Smaller amounts were less active and illtracerebral or subcutaneous inoculation was less effective than intraperitoneal. The toxic substance was very labile and could not be demonstrated after the suspensions had been treated in any manner which killed the Rickettsiae. Serum from individuals who had 463

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Chemotherapy of Lymphogranuloma Venereum with Sulfonamide Drugs

Cited by 21 publications

References 0 publications

The Mode of Action of the Sulfonamides

The Mode of Action of the Sulfonamides

The Effect of Para-Aminobenzoic Acid on the Chemotherapeutic Activity of the Sulfonamides in Lymphogranuloma Venereum and in Duck Malaria

Studies on Lymphogranuloma Venereum

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