Chemotherapy with Hybrid Liposomes for Melanomatosis.

Kanno, Akihiro; Tsuzaki, Kenji; Miyagi, Makoto; Matsumoto, Yōko; Ueoka, Ryuichi

doi:10.1248/bpb.22.1013

Cited by 12 publications

(2 citation statements)

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“…関する研究も行われている． 7,8) 最近，焼酎粕そのものの培養がん細胞に対する抗腫瘍効果が報告された． [9][10][11] 本研究では，微生物を利用して，バイオマス中に抗腫瘍性物質を生産させ，医薬品の開発に資することを目的としている．上岡らは既に，リポソームのみによる in vitro での顕著ながん細胞増殖抑制効果を， 12,13) また in vivo での担がんマウスの延命効果 [14][15][16] 及び臨床への応用を報告している． 17,18) さらに，リポソームをドラッグデリバリーシステムのキャリアーとして用い，in vitro での治療効果を得ている． 19…”

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Production of Antitumor Substances from Shochu Distillation Remnants

Tsuchiya

Tsuzaki²,

Nishimura³

et al. 2006

YAKUGAKU ZASSHI

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This study aimed to develop a new processing method for the eŠective use of rice shochu distillation remnants. We examined the inhibitory eŠects on the growth of human lung carcinoma cells in the medium of rice shochu distillation remnants with various fungi. Interestingly, high inhibitory eŠects on the growth of human lung carcinoma cells in the medium of rice shochu distillation remnants with Aspergillus oryzae were obtained, although no inhibitory eŠect was observed in the case of synthetic medium. We therefore fractionated the medium of rice shochu distillation remnants with A. oryzae using anion-exchange and reverse-phase chromatography. Furthermore, we attempted to determine the chemical structure of compounds that showed high inhibitory eŠects on the growth of tumor cells. The chemical structure of 1-hydroxy-6-(1-methylpropyl)-3-(2-methylproryl)-2(1H)-pyrazinone was revealed on the basis of liquid and gas mass spectroscopies. This compound should be completely safe based on toxic test results using model mice.

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Production of Antitumor Substances from Shochu Distillation Remnants

Tsuchiya

Tsuzaki²,

Nishimura³

et al. 2006

YAKUGAKU ZASSHI

Self Cite

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“…5 It was also demonstrated that hybrid liposomes without drugs should inhibit the proliferation of various tumor cells in vitro and in vivo. [6][7][8][9][10][11][12][13] In this study, the inhibitory effects of hybrid liposomes composed of phospholipids having the same hydrophilic head group (phosphatidylcholine group) and different hydrophobic alkyl chains (L L-a-dilauroylphosphatidylcholine ( Hybrid liposomes were prepared by sonication of a mixture of vesicular (DLPC, DMPC or DPPC) and micellar (C 12 (EO) 23 ) molecules in 5% glucose solution at 45°C in a nitrogen atmosphere and, subsequently, filter-sterilized through a 0.20 lm pore filter.…”

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confidence: 99%