Chemotherapy with hybrid liposomes for cancer: An experimental study.

Kanno, Akihiro; Kodama, Ryuhei; Terada, Yasutaka; Matsumoto, Yōko; Ueoka, Ryuichi

doi:10.2745/dds.13.101

Cited by 9 publications

(3 citation statements)

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“…In addition, Nakano et al (19) also found growth inhibition when hybrid liposome was added to human hepatoma cells in vitro. Furthermore, the hybrid liposomes have been found to have a highly inhibitory effect on mice model of carcinoma in vivo (20). Matsumoto et al (7) also reported that hybrid liposomes of lipid and micellar molecules inhibit the growth of HL-60 cells.…”

Section: Discussionmentioning

confidence: 96%

Butyrate-Induced Growth Inhibition and Differentiation in Caco-2 Cells with Hybrid Liposomes

et al. 2005

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Hybrid liposomes were prepared by mixing glycerophospholipids with glyceroglycolipids. The effects of hybrid liposomes on Caco-2 cells were investigated. Growth inhibition of cells was determined with sodium 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium dye reduction assay. Alkaline phosphatase activity was measured for assessing the cell differentiation induced by sodium butyrate (NaBT). Growth of Caco-2 cells was inhibited at 48 h after addition of all four types hybrid liposomes (PC/DGDG, PC/SQDG, PS/DGDG and PS/SQDG) while at 72 h growth inhibition was significant for all treatments except the hybrid liposome of phosphatidylcholine and digalactosyldiacylglycerol under concentrations of 50 mM glycerophospholipids with 50 mM glyceroglycolipids. Alkaline phosphatase activity of Caco-2 cells increased significantly when cells were treated in combination of hybrid liposomes and NaBT at 72 h, indicating that hybrid liposomes enhanced cell differentiation induced with NaBT.

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Section: Discussionmentioning

confidence: 96%

Butyrate-Induced Growth Inhibition and Differentiation in Caco-2 Cells with Hybrid Liposomes

et al. 2005

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“…3 Hybrid liposomes are highly expected to be very useful as a new material in the medical field because of their bioadaptability, easiness of preparation than the ordinary methods, and no contamination with any organic solvents. It has been reported that hybrid liposomes demonstrated remarkable inhibitory effects on the growth of lymphoma, 4À6 leukemia, 7 melanoma, 8 and lung adenocarcinoma 9 cells.…”

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confidence: 99%

“…11 Significantly prolonged survival was obtained using mice model of carcinoma in vivo. 8 It is well known that hydrophilic peptides like insulin are not sufficiently encapsulated to the liposomes. In order to improve the encapsulation of insulin into liposomes, we prepared the acylated insulins modified with hydrophobic groups, that is, long chain caproyl (Cap) and aromatic benzoyl (Bz) groups.…”

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confidence: 99%