Chemovirotherapeutic Treatment Using Camptothecin Enhances Oncolytic Measles Virus-Mediated Killing of Breast Cancer Cells

Tai, Chen Jei; Pan, Yu Chi; Wong, Shu Hui; Richardson, Christopher D.; Lin, Liang-Tzung

doi:10.1038/s41598-019-43047-3

Cited by 29 publications

(14 citation statements)

References 54 publications

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“…An increase in the number of neutrophils and the activation of the phagocytic cells also reported with V. Album[354]. Apoptosis was induced by the activation of its mitochondrial pathway [combined with oncolytic measles virus found to elicit the same therapeutic effect as high doses of camptothecin in breast adenocarcinoma[356].…”

supporting

confidence: 54%

Complementary and Alternative Treatments for Cancer Prevention and Cure (Part 1)

Mohiuddin¹

2019

JECT

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Many lay people along with some so called "key opinion leaders" have a common slogan "There's no answer for cancer". Again, mistake delays proper treatment and make situation worse, more often. Compliance is crucial to obtain optimal health outcomes, such as cure or improvement in QoL. Patients may delay treatment or fail to seek care because of high out-of-pocket expenditures. Despite phenomenal development, conventional therapy falls short in cancer management. There are two major hurdles in anticancer drug development: dose-limiting toxic side effects that reduce either drug effectiveness or the QoL of patients and complicated drug development processes that are costly and time consuming. Cancer patients are increasingly seeking out alternative medicine and might be reluctant to disclose its use to their oncology treatment physicians. But there is limited available information on patterns of utilization and efficacy of alternative medicine for patients with cancer. As adjuvant therapy, many traditional medicines shown efficacy against brain, head and neck, skin, breast, liver, pancreas, kidney, bladder, prostate, colon and blood cancers. The literature reviews non-pharmacological interventions used against cancer, published trials, systematic reviews and meta-analyses.

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confidence: 54%

Complementary and Alternative Treatments for Cancer Prevention and Cure (Part 1)

Mohiuddin¹

2019

JECT

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“…Among the different approaches that are currently being considered and despite their limited efficacy when delivered as a monotherapy [99], oncolytic viruses have demonstrated their safety [100] and ability in targeting and killing cancer cells as well as in stimulating immunotherapeutic effects in patients [101], positioning themselves as a promising strategy to increase treatment efficacy when used in combination therapy [99][100][101] and as a unique platform for personalized treatment of patients with advanced breast cancer [101].…”

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confidence: 99%

Immunotherapy: A Challenge of Breast Cancer Treatment

García-Aranda

Redondo

2019

Cancers

140

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Breast cancer is the most commonly diagnosed cancer in women and is a leading cause of cancer death in women worldwide. Despite the significant benefit of the use of conventional chemotherapy and monoclonal antibodies in the prognosis of breast cancer patients and although the recent approval of the anti-PD-L1 antibody atezolizumab in combination with chemotherapy has been a milestone for the treatment of patients with metastatic triple-negative breast cancer, immunologic treatment of breast tumors remains a great challenge. In this review, we summarize current breast cancer classification and standard of care, the main obstacles that hinder the success of immunotherapies in breast cancer patients, as well as different approaches that could be useful to enhance the response of breast tumors to immunotherapies.

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“…To avoid this bias, we used anticancer drug, the natural compound camptothecin (CPT) found in the Chinese ornamental tree, Camptotheca acuminata. CPT is known to exhibit anticancer activity in various cancer cells [42][43][44]. In this study, we checked the effect of ectopic wild-type p53 on CPT-induced cell death in p53-null HCT116 cells.…”

Section: Discussionmentioning

confidence: 99%

p53 Enhances Artemisia annua L. Polyphenols-Induced Cell Death Through Upregulation of p53-Dependent Targets and Cleavage of PARP1 and Lamin A/C in HCT116 Colorectal Cancer Cells

Jung

Lee

Paramanantham

et al. 2020

IJMS

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Plant-derived natural polyphenols exhibit anticancer activity without showing any noticeable toxicities to normal cells. The aim of this study was to investigate the role of p53 on the anticancer effect of polyphenols isolated from Korean Artemisia annua L. (pKAL) in HCT116 human colorectal cancer cells. We confirmed that pKAL induced reactive oxygen species (ROS) production, propidium iodide (PI) uptake, nuclear structure change, and acidic vesicles in a p53-independent manner in p53-null HCT116 cells through fluorescence microscopy analysis of DCF/PI-, DAPI-, and AO-stained cells. The pKAL-induced anticancer effects were found to be significantly higher in p53-wild HCT116 cells than in p53-null by hematoxylin staining, CCK-8 assay, Western blot, and flow cytometric analysis of annexin V/PI-stained cells. In addition, expression of ectopic p53 in p53-null cells was upregulated by pKAL in both the nucleus and cytoplasm, increasing pKAL-induced cell death. Moreover, Western bot analysis revealed that pKAL-induced cell death was associated with upregulation of p53-dependent targets such as p21, Bax and DR5 and cleavage of PARP1 and lamin A/C in p53-wild HCT116 cells, but not in p53-null. Taken together, these results indicate that p53 plays an important role in enhancing the anticancer effects of pKAL by upregulating p53 downstream targets and inducing intracellular cell death processes.

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Chemovirotherapeutic Treatment Using Camptothecin Enhances Oncolytic Measles Virus-Mediated Killing of Breast Cancer Cells

Cited by 29 publications

References 54 publications

Complementary and Alternative Treatments for Cancer Prevention and Cure (Part 1)

Complementary and Alternative Treatments for Cancer Prevention and Cure (Part 1)

Immunotherapy: A Challenge of Breast Cancer Treatment

p53 Enhances Artemisia annua L. Polyphenols-Induced Cell Death Through Upregulation of p53-Dependent Targets and Cleavage of PARP1 and Lamin A/C in HCT116 Colorectal Cancer Cells

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