Chenodeoxycholic acid attenuates ovalbumin-induced airway inflammation in murine model of asthma by inhibiting the T H 2 cytokines

Shaik, Firdose Begum; Panati, Kalpana; Narasimha, Vydyanath R.; Narala, Venkata Ramireddy

doi:10.1016/j.bbrc.2015.05.104

Cited by 35 publications

(20 citation statements)

References 43 publications

(40 reference statements)

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“…Moreover, chlorogenic acid was identified to inhibit avian influenza polymerase activity as a ligand (Li et al, ). In addition, ursodeoxycholic acid (Willart et al, ) and chenodeoxycholic acid (Shaik, Panati, Narasimha, & Narala, ) had an anti‐inflammatory effect in airway inflammation in a murine model. Therefore, baicalin, ursodeoxycholic acid, chenodeoxycholic acid, caffeic acid, chlorogenic acid and their analogs may be anti‐influenza bioactive components in TRQ.…”

Section: Resultsmentioning

confidence: 99%

Material basis studies of anti‐Influenza A active ingredients in Tanreqing Injection

Zhu

Chen

Shi

et al. 2017

Biomedical Chromatography

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Tanreqing Injection (TRQ) has been used primarily in treating infections of the upper respiratory tract and serious influenza in China, as a classical compound herbal recipe. TRQ had been demonstrated to have effects of clearing heat, eliminating phlegm, detoxification, reducing inflammation and alleviating cough. The survival rate, histopathology of lungs and viral titers in mice were evaluated in this study to verify the curative effect of TRQ. However, there is not enough information about the components. In the present study, a high-performance and practical LC/QTOF/MS method was developed for characterization and identification of the natural ingredients in TRQ. A total of 60 compounds, including 10 amino acids, 10 iridoid glucosides, 14 flavonoids, 13 other phenolic compounds, 10 steroid acids and three other compounds, were characterized and identified. We also confirmed the material basis of anti-Influenza A active ingredients in TRQ. Therefore, we have developed an accurate analytical method. LC/QTOF/MS could be applied for identification the complex components in traditional Chinese medicine.

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Section: Resultsmentioning

confidence: 99%

Material basis studies of anti‐Influenza A active ingredients in Tanreqing Injection

Zhu

Chen

Shi

et al. 2017

Biomedical Chromatography

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“…The crucial role that the UPR plays in chronic airway disorders highlights its potential as a target for novel therapies in diseases such as asthma (6,16). Our group and others have demonstrated the therapeutic potential of the conjugated bile acid (CBA) tauroursodeoxycholic acid (TUDCA) in relieving ER stress and airway inflammatory responses (7,17,18). CBAs such as TUDCA are generally well tolerated and have shown positive effects in clinical trials for UPR-related diseases, such as primary biliary cholangitis, amyloidosis, and amyotrophic lateral sclerosis (19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers

Nakada¹,

Bhakta²,

Korwin-Mihavics³

et al. 2019

JCI Insight

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“…Ursodeoxycholic acid, a chemical component of primary bile acid metabolism, has been reported to suppress the infiltration of eosinophils into the airway by inhibiting the activity of dendritic cells [57]. Chenodeoxycholic acid, discovered to be perturbed, has been revealed by a previous study to have the potential to eliminate OVA-induced airway Th2 inflammation and lower the level of related cytokines [58].…”

Section: Discussionmentioning

confidence: 99%

Phenotype-Specific Therapeutic Effect of Rhodiola wallichiana var. cholaensis Combined with Dexamethasone on Experimental Murine Asthma and Its Comprehensive Pharmacological Mechanism

Pang

Ran

Yuan

et al. 2019

IJMS

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The heterogeneity of asthma involves complex pathogenesis leading to confusion regarding the choice of therapeutic strategy. In the clinic, asthma is commonly classified as having either eosinophilic asthma (EA) or non-eosinophilic asthma (NEA) phenotypes. Microbiota colonizing in airways has been demonstrated to induce distinct phenotypes of asthma and the resistance to steroids. Rhodiola wallichiana var. cholaensis (RWC) has the potential to alleviate asthmatic inflammation according to recent studies, but its pharmacological mechanisms remain unclarified. In our study, murine asthmatic phenotypes were established and treated with RWC and/or dexamethasone (DEX). Combined treatment with RWC and DEX could improve spirometry and airway hyperresponsiveness (AHR) in asthmatic phenotypes, alleviate steroid resistance in NEA, and reduce the inflammatory infiltration of the both phenotypes. The combined treatment increased Th1, regulated the imbalance of Th2/Th1, and decreased the related cytokines in EA. As for NEA, the combined treatment reduced Th17 and promoted the accumulation of regulatory T cells (Tregs) in lung. A microbiome study based on 16S rDNA sequencing technique revealed the significantly changed structure of the lower airway microbiota after combined treatment in NEA, with 4 distinct genera and 2 species identified. OPLS-DA models of metabolomics analysis based on UPLC-Q/TOF-MS technique identified 34 differentiated metabolites and 8 perturbed metabolic pathways. A joint multiomics study predicted that the colonized microbiota in airways might be associated with susceptibility of asthma and steroid resistance, which involved systematic and pulmonary metabolic perturbation. In summary, the pharmacological network of RWC included the complicated interaction mechanisms of immune regulation, microbiota change, and metabolic perturbation.

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Chenodeoxycholic acid attenuates ovalbumin-induced airway inflammation in murine model of asthma by inhibiting the T H 2 cytokines

Cited by 35 publications

References 43 publications

Material basis studies of anti‐Influenza A active ingredients in Tanreqing Injection

Material basis studies of anti‐Influenza A active ingredients in Tanreqing Injection

Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers

Phenotype-Specific Therapeutic Effect of Rhodiola wallichiana var. cholaensis Combined with Dexamethasone on Experimental Murine Asthma and Its Comprehensive Pharmacological Mechanism

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