Chenodeoxycholic acid regulates fibroblast growth factor 23 gene expression via estrogen-related receptor γ in human hepatoma Huh7 cells

Fan, Yuhang; Kim, Hyojin; Jung, Yoon Seok; Na, Soon-Young; Radhakrishnan, Kamalakannan; Choi, Hueng Sik

doi:10.1016/j.steroids.2023.109257

Cited by 2 publications

(1 citation statement)

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“…Furthermore, various factors, including gene mutations for the BA synthesis and transport, high-fat diets, medications, and circadian rhythm disturbances, are found to mediate the pathologies of multiple diseases that involve cholestatic liver disease, inflammatory bowel disease, diabetes, obesity, tumors, and related metabolic disorders ( Li and Chiang, 2014 ; Fiorucci et al, 2021 ; Fu et al, 2021 ; Perino et al, 2021 ; Yang et al, 2021 ; Shi et al, 2023 ). In recent years, several researches have demonstrated that BAs have antitumor properties in various cancer cell types, such as tamoxifen-resistant breast cancer ( Luu et al, 2018 ; Kovács et al, 2019 ), oral squamous cell carcinoma ( Talebian et al, 2020 ), cholangiocarcinoma ( Lee et al, 2022 ), gastric cancer ( Zhang et al, 2022 ), colon cancer ( Kim E. K. et al, 2017 ), hepatocellular carcinoma ( Fan et al, 2023 ), prostate cancer ( Lee et al, 2017 ), gallbladder cancer ( Lin et al, 2020 ; Li et al, 2022 ), neuroblastoma ( Trah et al, 2020 ) etc., by inhibiting cancer cell proliferation and migration. In addition, new BA derivatives have been synthesized in several laboratories to investigate their anticancer properties.…”

Section: Introductionmentioning

confidence: 99%

The anticancer activity of bile acids in drug discovery and development

Li,

Zou,

Huang

et al. 2024

Front. Pharmacol.

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Bile acids (BAs) constitute essential components of cholesterol metabolites that are synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the biliary system. They play a crucial role in nutrient absorption, lipid and glucose regulation, and the maintenance of metabolic homeostasis. In additional, BAs have demonstrated the ability to attenuate disease progression such as diabetes, metabolic disorders, heart disease, and respiratory ailments. Intriguingly, recent research has offered exciting evidence to unveil their potential antitumor properties against various cancer cell types including tamoxifen-resistant breast cancer, oral squamous cell carcinoma, cholangiocarcinoma, gastric cancer, colon cancer, hepatocellular carcinoma, prostate cancer, gallbladder cancer, neuroblastoma, and others. Up to date, multiple laboratories have synthesized novel BA derivatives to develop potential drug candidates. These derivatives have exhibited the capacity to induce cell death in individual cancer cell types and display promising anti-tumor activities. This review extensively elucidates the anticancer activity of natural BAs and synthetic derivatives in cancer cells, their associated signaling pathways, and therapeutic strategies. Understanding of BAs and their derivatives activities and action mechanisms will evidently assist anticancer drug discovery and devise novel treatment.

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