Chenopodium ambrosioides var. ambrosioides leaf extracts possess regenerative and ameliorative effects against mercury-induced hepatotoxicity and nephrotoxicity

Ogunleye, Gbenga S.; Fagbohun, Oladapo F.; Babalola, O. O.

doi:10.1016/j.indcrop.2020.112723

Cited by 10 publications

(4 citation statements)

References 63 publications

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“…Many nutraceuticals containing well-known traditional plants are utilized for their liver and/or kidney health benefits. Extracts of Nigella sativa [ 46 ], Chenopodium ambrosioides [ 47 ], Hemidesmus indicus [ 48 ], Bryophyllum pinnatum [ 49 ] and Verbascum thapsus [ 50 ] are reported to have hepatoprotective and/or nephroprotective effects. Interestingly, Verbascum thapsus is rich in iridoid contents [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

In Vivo Hepatoprotective and Nephroprotective Activity of Acylated Iridoid Glycosides from Scrophularia hepericifolia

Abdel‐Kader

Alqasoumi

2021

Biology

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Phytochemical investigation of the chloroform fraction obtained from Scrophularia hypericifolia aerial parts led to the isolation of nine acylated iridoid glycosides. The new compounds were identified as 6-O-α-L(2”-acetyl, 3”,4”-di-O-trans-cinnamoyl) rhamnopyranosyl-6’-acetyl catalpol (6’-acetyl hypericifolin A) (1), 6-O-α-L(2”, 4”-diacetyl, 3”-O-trans-cinnamoyl) rhamnopyranosyl-6’-acetyl catalpol (6’-acetyl hypericifolin B) (2), 6-O-α-L(2”-acetyl, 3”,4”-di-O-trans-cinnamoyl) rhamnopyranosyl catalpol (hypericifolin A) (3) and 6-O-α-L(2”, 4”-diacetyl, 3"-O-trans-cinnamoyl) rhamnopyranosyl catalpol (hypericifolin B) (4). Previously reported compounds were identified as laterioside (5), 8-O-acetylharpagide (6), 6-O-α-L(4’-O-trans-cinnamoyl) rhamnopyranosyl catalpol (7), lagotisoside D (8) and harpagoside (9). Identification achieved via analyses of physical and spectral data including 1D, 2D NMR and High Resolution Electrospray Ionization Mass spectroscopy (HRESIMS). Compounds 2–4 and 6 were subjected to biological evaluation against paracetamol-induced toxicity. The biochemical parameters aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transpeptidase (GGT) as well as total bilirubin were used to access the liver condition. Measurement of serum levels of urea, creatinine, sodium and potassium cations were indicators for kidney condition. Liver and kidney samples were subjected to histopathological study. The best protection was found in the group treated with 3 followed by 4 and 6, while 2 was almost inactive.

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Section: Resultsmentioning

confidence: 99%

In Vivo Hepatoprotective and Nephroprotective Activity of Acylated Iridoid Glycosides from Scrophularia hepericifolia

Abdel‐Kader

Alqasoumi

2021

Biology

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“…Inhibition of the growth of surrounding plants by the release of volatile allelochemicals has been shown to be the main mechanism of successful invasion of C. ambrosioides [11,12]. The whole plant is rich in volatile compounds, and more than 20 compounds have been identified in the volatile oil of C. ambrosioides, among which α-terpinene is a common component in different populations and has been shown by the research group to be the primary allelochemical of C. ambrosioides [13,14]. It has also been shown that α-terpinene can become fixed in soil ecosystems by adsorption [10].…”

Section: Introductionmentioning

confidence: 99%

Receptor Plants Alleviated Allelopathic Stress from Invasive Chenopodium ambrosioides L. by Upregulating the Production and Autophagy of Their Root Border Cells

Wang,

Zhou,

et al. 2023

Plants

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Chenopodium ambrosioides L. is an invasive plant native to the Neotropics that has seriously threatened the ecological security of China, and allelopathy is one of the mechanisms underlying its successful invasion. Maize (Zea mays L.) and soybean (Glycine max (L.) Merr.), as the main food crops, are usually affected by C. ambrosioides in their planting areas. The purpose of this study was to investigate the ultrastructure, autophagy, and release-related gene expression of receptor plant root border cells (RBCs) after exposure to volatile oil from C. ambrosioides and its main component α-terpene, which were studied using maize and soybean as receptor plants. The volatiles inhibited root growth and promoted a brief increase in the number of RBCs. As the volatile concentration increased, the organelles in RBCs were gradually destroyed, and intracellular autophagosomes were produced and continuously increased in number. Transcriptomic analysis revealed that genes involved in the synthesis of the plasma membrane and cell wall components in receptor root cells were significantly up-regulated, particularly those related to cell wall polysaccharide synthesis. Meanwhile, polygalacturonase and pectin methylesterases (PME) exhibited up-regulated expression, and PME activity also increased. The contribution of α-terpene to this allelopathic effect of C. ambrosioides volatile oil exceeded 70%. Based on these results, receptor plant root tips may increase the synthesis of cell wall substances while degrading the intercellular layer, accelerating the generation and release of RBCs. Meanwhile, their cells survived through autophagy of RBCs, indicating the key role of RBCs in alleviating allelopathic stress from C. ambrosioides volatiles.

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“…Dysphania ambrosioides (L.) Mosyakin and Clemants belongs to the Chenopodiaceae family and is locally known in Morocco as “M’Khinza”. Several ethnobotanical studies have revealed that the indigenous Moroccan people employed D. ambrosioides to treat a variety of diseases, including fever, female infertility, rheumatism, sexual impotence [ 10 ], digestive disorders, nervous system problems, and respiratory issues [ 11 , 12 ]. It is also used in traditional medicine for its antifungal, antiaflatoxigenic, and pesticide properties [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Acute and Subacute Toxicity and LC-MS/MS Compositional Alkaloid Determination of the Hydroethanolic Extract of Dysphania ambrosioides (L.) Mosyakin and Clemants Flowers

Kandsi

Lafdil

Elbouzidi

et al. 2022

Toxins

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Dysphania ambrosioides (L.) Mosyakin and Clemants is a medicinal plant that has traditionally been used to cure a range of diseases. There has been no thorough investigation of the potential toxicity of this plant. The objective of this study is to assess the acute and subacute toxicity of D. ambrosioides hydroethanolic extract (DAHE), as well as it alkaloids composition, utilizing LC-MS/MS analysis. An in silico approach was applied to determine pharmacokinetic parameters and to predict the toxicity of D. ambrosioides identified alkaloids. A 14-day treatment with a single oral dose of 1–7 g/kg was carried out to investigate acute toxicity. DAHE was given orally at dosages of 5, 50, and 500 mg/kg for 15 days in the subacute toxicity investigation, and body weight and biochemical parameters were evaluated. Livers, kidneys, lungs, and heart were examined histologically. Chromatographic investigation revealed the existence of nine alkaloids, with N-formylnorgalanthamine being the most prevalent. The oral LD50 value of DAHE was found to be 5000 mg/kg in an acute toxicity study. No variations were observed with respect to food intake, water consumption, mortality, or body and organ weight in the subacute toxicity study. On the other hand, DAHE (500 mg/kg) significantly enhanced alanineaminotransferase, aspartate aminotransferase, and urea. Liver and kidney histological examinations revealed modest infiltration of hepatocyte trabeculae by inflammatory cells in the liver and slight alteration in the kidney histoarchitecture. According to our findings, DAHE exhibits low to moderate toxicity.

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Chenopodium ambrosioides var. ambrosioides leaf extracts possess regenerative and ameliorative effects against mercury-induced hepatotoxicity and nephrotoxicity

Cited by 10 publications

References 63 publications

In Vivo Hepatoprotective and Nephroprotective Activity of Acylated Iridoid Glycosides from Scrophularia hepericifolia

In Vivo Hepatoprotective and Nephroprotective Activity of Acylated Iridoid Glycosides from Scrophularia hepericifolia

Receptor Plants Alleviated Allelopathic Stress from Invasive Chenopodium ambrosioides L. by Upregulating the Production and Autophagy of Their Root Border Cells

Evaluation of Acute and Subacute Toxicity and LC-MS/MS Compositional Alkaloid Determination of the Hydroethanolic Extract of Dysphania ambrosioides (L.) Mosyakin and Clemants Flowers

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