Chenopodium ambrosioides var. ambrosioides used in Moroccan traditional medicine can enhance the antimicrobial activity of conventional antibiotics

Brahim, Malika Ait Sidi; Fadli, Mariam; Hassani, Lahcen; Boulay, Brahim; Markouk, Mohamed; Bekkouche, Khalid; Abbad, Abdelaziz; Ali, Mustapha Ait; Larhsini, Mustapha

doi:10.1016/j.indcrop.2015.03.067

Cited by 41 publications

(15 citation statements)

References 41 publications

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“…Two isomers of terpinene were found, and β-terpinene (3.82%) has been the most cited than αterpinene (2.94%). However, from 37 studies on chemical composition essential oil of C. ambrosioides, as presented in the above table, α-terpinene was found to be the main constituent (40.5%) of essential oils from different countries include Brazil [197][198][199], Cameroon [200], China [201], Colombia [202], Egypt [203], India [204][205][206], Morocco [207], Nigeria [13], and Rwanda [208]. His concentration was variable according to countries and used parts.…”

Section: Phytochemistrymentioning

confidence: 99%

Ethnomedical uses, chemical constituents, and evidence-based pharmacological properties of Chenopodium ambrosioides L.: extensive overview

et al. 2021

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Background The Chenopodium genus is a plant family widely spread worldwide that includes various plant species reputed to possess several medicinal virtues in folk medicines. Chenopodium ambrosioides L. is among the most used plants in traditional medicines worldwide. This review aimed to highlight ethnomedicinal uses, phytochemical status, and pharmacological properties of C. ambrosioides L. Main body of the abstract The analysis of relevant data highlights various ethnomedicinal uses against human and veterinary diseases in forty countries. Most indications consisted of gastrointestinal tract dysfunctioning troubles and worms parasitemia. Around 330 chemical compounds have been identified in different plant parts, especially in its essential oil fractions (59.84%). However, only a few compounds—mainly monoterpenes and glycosides—have been isolated and characterized. Experimental pharmacological studies validated a large scale of significant health benefits. It appeared that many monoterpenes are antioxidant, insecticidal, trypanocidal, analgesic, antifungal, anti-inflammatory, anti-arthritic, acaricidal, amoebicidal, anthelmintic, anticancer, antibacterial, antidiabetic, antidiarrheal, antifertility, antifungal, anti-leishmanial, antimalarial, antipyretic, antisickling, antischistosomal, antiulcer, anxiolytic, immunomodulatory, molluscicidal, and vasorelaxant agents. Short conclusion Thus, the Chenopodium ambrosioides species necessitates further chemical studies to isolate and characterize new bioactive secondary metabolites and pharmacological investigations to precise the mechanisms of action before clinical trials.

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Section: Phytochemistrymentioning

confidence: 99%

Ethnomedical uses, chemical constituents, and evidence-based pharmacological properties of Chenopodium ambrosioides L.: extensive overview

et al. 2021

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“…Natural products, such as essential oils, have historically proven their value as a source of molecules with antimicrobial potential, and may have high potential in bacterial and fungal infections in the near future. Indeed, the synergistic interaction of essential oils with antimicrobials has been previously reported as a valid approach to prevent the emergence of multidrug resistance by restoring their antimicrobial effect and reducing adverse effects of synthetic antimicrobials 1 .…”

Section: Introductionmentioning

confidence: 99%

Chemotype of damask rose with oleic acid (9 octadecenoic acid) and its antimicrobial effectiveness

Ghavam

Afzali

Manca

2021

Sci Rep

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Essential oils are natural products that have great antimicrobial potential value against many fungi and bacteria. Rosa damascena Mill. is one of the most important aromatic species of the Rosaceae family from which essential oil and economically valuable products can be obtained. The present study was designed to investigate the major compositions of the essential oil of this plant in Isfahan region of Iran and to identify its antibacterial and antifungal effects against 11 microorganisms causing human diseases and food spoilage. The essential oil was extracted by using the Clevenger apparatus and was analyzed by gas chromatography-mass spectrometry (GC–MS) technique. Its antimicrobial activity was evaluated by well diffusion, minimum inhibitory concentration (MIC) and minimum bactericide concentration (MBC). The results showed that the most important compounds of the essential oil were nonadecane (24.72%), heneicosane (19.325%), oleic acid (17.63%), and citronellol (12.61%). The results also showed that the highest inhibition zone of rose essential oil was against Aspergillus brasiliensis (15.00 ± 0.00 mm) and had a significant effect on Klebsiella pneumoniae (~ 8.00 mm). Also the rose oil had a significant inhibition and lethal effect against Candida albicans (MIC and MBC ~ 125 μg/mL), which is equivalent to the nystatin antibiotic (~ 125 μg/mL). Therefore, the essential oil of Damask rose can be considered as an alternative natural product for the prevention and treatment of fungal diseases in humans and against food spoilage as well.

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“…After identifying toward which traditional antibiotics the bacteria selected for this study had low sensitivity, these antimicrobials were used in the benzophenone synergism assay in serial dilutions of 2 × MIC. The Checkerboard method was used according to Brahim et al (2015) with minor modifications; 50 μL of said antimicrobials were placed along each well of the ordinates of the 96 well microtiter plate and the benzophenone dilutions were arranged along the abscissa (50 μL). Then, 100 μL of the bacterial suspension (1 × 10 4 CFU/mL) was added to each well.…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial and Synergistic Activity of 2,2′,4-Trihydroxybenzophenone Against Bacterial Pathogens of Poultry

et al. 2019

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In poultry farming, the spread of bacterial pathogens results in disease outbreaks causing significant economic losses to this industry. Many of these pathogenic bacteria are zoonotic and have a substantial impact on public health. Antimicrobials are essential for the prevention and treatment of these bacterial infections. However, the indiscriminate use of these agents provides favorable conditions for selection, propagation and persistence of bacteria and development of antimicrobial resistance. We developed a new antimicrobial candidate that could be used alone or in synergy with research protocols for therapeutic, prophylactic and growth promoter uses in the poultry industry. The present study aimed at evaluating the antimicrobial activity of the synthetic compound 2,2′,4-trihydroxybenzophenone against pathogenic bacteria that cause important diseases in poultry and public health. We tested the hemolytic effect of this compound, studied its synergistic effect with conventional antimicrobials and analyzed the site of action on the bacteria. The results of our study showed antimicrobial activity of benzophenone against Gram-positive and Gram-negative bacteria with a similar effect in ATCC (American type culture collection) and field isolates. This compound was non-hemolytic. 2,2′,4-trihydroxybenzophenone acted on the bacterial cell wall. We identified the synergistic effect between 2,2′,4-trihydroxybenzophenone and bacitracin, this effect indicate that antimicrobial synergism may be useful for the treatment of necrotic enteritis in poultry. This compound may also be used as a growth promoter by reducing the dose of bacitracin and thus decreasing the pressure of bacterial resistance in poultry which would circumvent the development of cross-resistance in humans.

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Chenopodium ambrosioides var. ambrosioides used in Moroccan traditional medicine can enhance the antimicrobial activity of conventional antibiotics

Cited by 41 publications

References 41 publications

Ethnomedical uses, chemical constituents, and evidence-based pharmacological properties of Chenopodium ambrosioides L.: extensive overview

Ethnomedical uses, chemical constituents, and evidence-based pharmacological properties of Chenopodium ambrosioides L.: extensive overview

Chemotype of damask rose with oleic acid (9 octadecenoic acid) and its antimicrobial effectiveness

Antimicrobial and Synergistic Activity of 2,2′,4-Trihydroxybenzophenone Against Bacterial Pathogens of Poultry

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