Cherry juice alleviates high-fat diet-induced obesity in C57BL/6J mice by resolving gut microbiota dysbiosis and regulating microRNA

Wang, Zhen; Liu, Hongxu; Song, Guoku; Gao, Jie; Xia, Xiaodong; Qin, Ningbo

doi:10.1039/d2fo03023c

Cited by 3 publications

(2 citation statements)

References 50 publications

(85 reference statements)

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“…The difference between the ResNPs group and the DSS group was greater than the FRes group. 34 Principal component analysis plots show that the DSS group is the most distant from the healthy group, whereas the ResNPs are the closest to the healthy group, indicating that the two have a more similar composition (Fig. 7D).…”

Section: Influence Of Resnps On Intestinal Flora and Scfas Contentmentioning

confidence: 99%

Resveratrol‐loaded pH‐responsive Mesona chinensis polysaccharides‐zein nanoparticles for effective treatment of ulcerative colitis

Yang,

Lin,

Zhang

et al. 2024

J Sci Food Agric

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BACKGROUNDResveratrol (Res) is promising food functional factor with favorable antioxidant and anti‐inflammatory properties, although its poor water solubility and low bioavailability limit extensive application. Therefore, in combination with another promising polysaccharide (Mesona chinensis polysaccharides, MCP), Res‐loaded food nanocarriers (ResNPs) were developed to increase its water solubility, bioactivity and targeting properties. ResNPs were then applied to alleviate dextran sulfate sodium (DSS)‐induced ulcerative colitis.RESULTSResveratrol can be well encapsulated in MCP‐based nanoparticles in an amorphous state, improving its water solubility. ResNPs showed pH‐response controlled release behavior in the gastrointestinal tract and increased the enrichment of Res in the colon. In vivo experiments of ResNPs against DSS‐induced ulcerative colitis (UC) revealed that ResNPs significantly improved UC symptoms, modulated intestinal inflammation and down‐regulated oxidative stress levels compared to free Res. ResNPs also play an positive role with respect to inhibiting the mitogen‐activated protein kinase pathway and promoting the expression of tight junction proteins. In addition, ResNPs improved the species composition and relative abundance of intestinal flora in UC mice, which effectively regulated the balance of intestinal flora and promoted the production of short‐chain fatty acids.CONCLUSIONThese results suggest that MCP‐based nanoparticles can effectively improve the solubility of resveratrol and enhance its in vivo bioactivity. Moreover, the present study also provides a new strategy for the prevention and treatment of UC with food polyphenol. © 2024 Society of Chemical Industry.

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Section: Influence Of Resnps On Intestinal Flora and Scfas Contentmentioning

confidence: 99%

Resveratrol‐loaded pH‐responsive Mesona chinensis polysaccharides‐zein nanoparticles for effective treatment of ulcerative colitis

Yang,

Lin,

Zhang

et al. 2024

J Sci Food Agric

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“…Как показывают проведенные опыты, вкусный кисло-сладкий фреш способствует уменьшению количества липидов в крови, а также снижению массы тела. [17] Внесите в ваш диетический рацион эффективную добавку в виде освежающего вишневого сока, чтобы уже в ближайшее время увидеть разительные преображения в зеркальном отражении!…”

Section: эффективен в профилактике ожиренияunclassified

Вишневый Сок — Ароматный Напиток Здоровья И Долголетия, 11 Научных Доказательств

Ткачева Наталья,

Елисеева Татьяна

2023

ЖЗПД

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Чуть терпковатые кисло-сладкие плоды вишни широко применяется в современной кулинарии как в свежем, так и в переработанном виде. Их них готовят джемы, муссы, соусы и варенья, используют для приготовления разнообразных кондитерских изделий и ароматной выпечки, а также отжимают из них вкусный освежающий фреш. Богатый разнообразными витаминами и полезными микроэлементами вишневый сок часто применяется в народной медицине. Но использовать для оздоровления организма рекомендуется не покупной, а самостоятельно приготовленный и не содержащий консерванты и дополнительные ингредиенты напиток. HTML версия статьи на сайте edaplus.info.

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The Gut Microbial Regulation of Epigenetic Modification from a Metabolic Perspective

Lin,

Han,

Wang

et al. 2024

IJMS

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Obesity is a global health challenge that has received increasing attention in contemporary research. The gut microbiota has been implicated in the development of obesity, primarily through its involvement in regulating various host metabolic processes. Recent research suggests that epigenetic modifications may serve as crucial pathways through which the gut microbiota and its metabolites contribute to the pathogenesis of obesity and other metabolic disorders. Hence, understanding the interplay between gut microbiota and epigenetic mechanisms is crucial for elucidating the impact of obesity on the host. This review primarily focuses on the understanding of the relationship between the gut microbiota and its metabolites with epigenetic mechanisms in several obesity-related pathogenic mechanisms, including energy dysregulation, metabolic inflammation, and maternal inheritance. These findings could serve as novel therapeutic targets for probiotics, prebiotics, and fecal microbiota transplantation tools in treating metabolic disruptions. It may also aid in developing therapeutic strategies that modulate the gut microbiota, thereby regulating the metabolic characteristics of obesity.

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Cherry juice alleviates high-fat diet-induced obesity in C57BL/6J mice by resolving gut microbiota dysbiosis and regulating microRNA

Abstract: Cherry is a nutrient-rich food that is good for health. This study demonstrated the inhibitory action of dietary cherry juice on high-fat diet (HFD)-induced obesity in mice. Cherry juice intervention...

Cited by 3 publications

References 50 publications

Resveratrol‐loaded pH‐responsive Mesona chinensis polysaccharides‐zein nanoparticles for effective treatment of ulcerative colitis

Resveratrol‐loaded pH‐responsive Mesona chinensis polysaccharides‐zein nanoparticles for effective treatment of ulcerative colitis

Вишневый Сок — Ароматный Напиток Здоровья И Долголетия, 11 Научных Доказательств

The Gut Microbial Regulation of Epigenetic Modification from a Metabolic Perspective

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