Cherubism: an unusual cause of bilateral mandibular swellings

Atalar, Mehmet Haydar; Arslan, Mübeccel; Aker, Handan; Müslehiddinoğlu, Ahmet

doi:10.1016/s1571-4675(03)00127-5

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Multiplane and three-dimensional CT imaging elucidate the accurate extent of the disease. Magnetic resonance imaging (MRI) features of cherubism described in the literature are nonspecific, but it is useful in clarifying the extent, particularly proximity of the cherubic lesions to the orbits and the optic nerves [ 5 - 6 ]. In our case, no sign or symptoms were present to indicate an MRI investigation.…”

Section: Discussionmentioning

confidence: 99%

Non-Familial Cherubism with Bilateral Maxilla and Mandible Involvement – Clinicoradiographic Findings

Ali¹,

Karjodkar²,

Sansare³

et al. 2016

Cureus

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Cherubism is a self-limiting non-neoplastic autosomal dominant fibro-osseous syndrome of the jaws. It is occasionally manifested before the age of two years. It occurs in children and more often in boys. It is characterized by notable clinical bilateral swelling of the cheeks due to a bony enlargement of the jaws that impart a characteristic ‘cherubic’ look. Regression occurs in the course of puberty leaving a few facial deformities and malocclusion. Cherubism might occur in solitary cases or in several members of the family, often in many generations. The reported case is an example of solitary sporadic occurrence within a family, which is a rarely documented condition in the literature.

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Section: Discussionmentioning

confidence: 99%

Non-Familial Cherubism with Bilateral Maxilla and Mandible Involvement – Clinicoradiographic Findings

Ali¹,

Karjodkar²,

Sansare³

et al. 2016

Cureus

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“…This is difficult to establish on the base of plain CT, therefore multiplanar and three-dimensional reconstructions are obligatory [ 12 ]. Magnetic resonance imaging (MRI) features of cherubism described in the literature are nonspecific, but this examination is useful in elucidating the accurate extent of the cherubic lesions, particularly their relationship to the orbits and the optic nerves [ 2 , 9 , 13 ]. In our case, there were no indications to perform an MR examination.…”

Section: Discussionmentioning

confidence: 99%

“…Besides, gigantiform cementoma lesions are located primarily in the maxilla and are enlarged in a focal rather than diffuse pattern. Bilateral odontogenic cysts are rare in the first 5 years of life [ 2 , 3 , 9 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical and radiological features of nonfamilial cherubism - a case report

et al. 2012

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SummaryBackground:Cherubism is an uncommon hereditary benign fibro-osseous disorder characterized by bilateral enlargement of the mandible and the maxilla that presents with varying degrees of involvement and a tendency toward spontaneous remission. On radiography cherubic lesions appear as cystic multilocular radiolucencies limited to the jaw bones.Case Report:A 5-year-old boy was referred to the Department of Maxillo-Facial Surgery due to deformation of the lower and middle section of the face and displacement or absence of teeth. A panoramic radiograph and a computed tomography revealed extensive multilocular, bilateral radiolucent areas and marked bony expansion in the mandible and maxilla, with sparing of the mandibular condyles. Histopathological evaluation of an incisional biopsy of the left maxilla and genotypic characterization confirmed the diagnosis of cherubism.Conclusions:The radiologic characteristics of cherubism are not pathognomonic but the diagnosis is strongly suggested by bilateral relatively symmetric jaw involvement that is limited to the jaw bones and, together with clinical and histopathologic findings, enables the diagnosis of cherubism. Genotypic characterization confirms the diagnosis.

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