Cherubism in a 4-year-old boy managed with tumor curettage, mandibular osteotomies and repositioning

Garlick, Jared W.; Willis, Rhett N.; Donato, Daniel P.; Gociman, Barbu

doi:10.20517/2347-9264.2018.36

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…Further details of this case have been published previously. 8 He most recently followed up at 36 months postoperative. He continues to be recurrence-free without clinical features of his cherubism diagnosis with all his teeth retained.…”

Section: Casementioning

confidence: 99%

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Severe Cherubism Treated with Curettage, Osteotomy, and Bony Repositioning: A Case Series of Three Patients

Moss

Pires

Zahid

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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Summary: Cherubism is a rare, autosomal dominant condition characterized by the replacement of medullary bone by fibro-osseous lesions, predominantly in the bilateral maxillae and/or mandibles. The clinical presentation of cherubism can vary widely, from clinically undetectable to severe facial disfigurement. Although there are no established management guidelines for this condition, conservative management with observation is typically favored in most cases due to the possibility of spontaneous regression following puberty. In this article, we present three cases of moderate to severe cherubism managed with early surgical intervention utilizing curettage and osteotomy followed by bony repositioning. We aimed to show the feasibility and safety of this minimally invasive surgical technique in the management of moderate to severe cases of cherubism to provide improvement in patient quality of life, aesthetics, and function while also possibly mitigating the need for later reconstructive surgery.

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Section: Casementioning

confidence: 99%

“…The aim of the study was to describe utilizing curettage and osteotomy followed by bony repositioning for the treatment of moderate to severe cherubism in a series of three patients. 8…”

mentioning

confidence: 99%

Severe Cherubism Treated with Curettage, Osteotomy, and Bony Repositioning: A Case Series of Three Patients

Moss

Pires

Zahid

et al. 2022

Plastic and Reconstructive Surgery - Global Open

Self Cite

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show abstract

“…Nevertheless, the removal of extensively distended bone is not recommended to avoid the risk of pathologic fracture [ 7 ]. Recent studies have advocated for early surgical intervention, taking into account the impact of cosmetic concerns on mental development and acknowledging that some cases may not regress by adulthood [ 9 ]. In some patients, pathologic tissue can be removed via liposuction [ 12 ].…”

Section: Literature Reviewmentioning

confidence: 99%

“…According to this classification, the patient corresponds to grade VI (Table 1). The widely accepted treatment for cherubism is observation, as it often resolves spontaneously [9]. Some studies suggest that the increased activity of osteoclasts typically normalizes at puberty due to the increased synthesis of sex steroid hormones [10].…”

Section: Literature Reviewmentioning

confidence: 99%

Surgical management of severe cherubism persisting into early adulthood: a case report and literature review

Choi,

Ji,

Kim

et al. 2024

Arch Craniofac Surg

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Cherubism is a rare fibro-osseous condition characterized by bilateral expansion of the mandible and maxilla. Due to its rarity, treatment guidelines for cherubism have not been clearly established. Observation without surgical intervention is typically recommended, as cherubism often regresses spontaneously after puberty. However, a surgical intervention may be necessary if aggressive lesions lead to severe complications. In this report, we present a case involving surgical management of cherubism that did not spontaneously regress until early adulthood. An 18-year-old man was diagnosed with cherubism, presenting characteristic upward-looking eyes and a swollen face. He strongly desired surgical management. Gross contouring of the mandible was performed using an osteotome. Subsequently, delicate contouring was performed by bone burring and curettage. The remaining multiple locular bony defects were filled with demineralized bone matrix. No major complications, including infection and hematoma, occurred during the 8-month follow-up period. The facial contour remained stable without the aggravation of cherubism. The patient was satisfied with the cosmetic results. Considering that cherubism is a rare disease globally, with few reported cases in Korea, and that treatment guidelines are not clearly established, we anticipate that the results of this case will contribute to the development of future protocols for treating cherubism.

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Cherubism in a 4-year-old boy managed with tumor curettage, mandibular osteotomies and repositioning

Cited by 2 publications

References 14 publications

Severe Cherubism Treated with Curettage, Osteotomy, and Bony Repositioning: A Case Series of Three Patients

Severe Cherubism Treated with Curettage, Osteotomy, and Bony Repositioning: A Case Series of Three Patients

Surgical management of severe cherubism persisting into early adulthood: a case report and literature review

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