Chest computed tomography (CT) features in children with reverse transcription‐polymerase chain reaction (RT‐PCR)‐confirmed COVID‐19: A systematic review

Simoni, Paolo; Bazzocchi, Alberto; Boitsios, Grammatina; Leucio, Alessandro De; Preziosi, Marco; Gómez, Maria Pilar Aparisi

doi:10.1111/1754-9485.13098

Cited by 11 publications

(15 citation statements)

References 65 publications

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“…Although the risk of severe illness is significantly lower than in adults, critical cases have been observed in the pediatric population, particularly in patients with underlying medical conditions[ 160 , 169 ]. The multisystem inflammatory syndrome in children (MIS-C) is a worrisome late complication that presents with multiorgan damage in children previously exposed to COVID-19.…”

Section: Pediatric Manifestationsmentioning

confidence: 99%

Imaging in the COVID-19 era: Lessons learned during a pandemic

Sidéris

Nikolakea²,

Karanikola³

et al. 2021

WJR

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The first year of the coronavirus disease 2019 (COVID-19) pandemic has been a year of unprecedented changes, scientific breakthroughs, and controversies. The radiology community has not been spared from the challenges imposed on global healthcare systems. Radiology has played a crucial part in tackling this pandemic, either by demonstrating the manifestations of the virus and guiding patient management, or by safely handling the patients and mitigating transmission within the hospital. Major modifications involving all aspects of daily radiology practice have occurred as a result of the pandemic, including workflow alterations, volume reductions, and strict infection control strategies. Despite the ongoing challenges, considerable knowledge has been gained that will guide future innovations. The aim of this review is to provide the latest evidence on the role of imaging in the diagnosis of the multifaceted manifestations of COVID-19, and to discuss the implications of the pandemic on radiology departments globally, including infection control strategies and delays in cancer screening. Lastly, the promising contribution of artificial intelligence in the COVID-19 pandemic is explored.

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Section: Pediatric Manifestationsmentioning

confidence: 99%

Imaging in the COVID-19 era: Lessons learned during a pandemic

Sidéris

Nikolakea²,

Karanikola³

et al. 2021

WJR

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“…CT investigations in pediatric COVID-19 patients are limited but consistently show that bilateral involvement occur more often than unilateral involvement and ground-glass opacity is the most common CT abnormalities [ 24 ]. In this study, the rate of bilateral patchy shadowing was also higher than the rate of unilateral patchy shadowing but only 19% of our COVID-19 cases showed ground-glass opacity, possibly due to the fact that CT investigation was performed at the very early stage of the disease.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of clinical features of SARS-CoV-2 and adenovirus infection among children

Wang

et al. 2020

Virol J

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Background The new emerging coronavirus disease 2019 (COVID-19) overall shares similar symptoms with other common respiratory viral infections. We aimed in this study to compare COVID-19 and human adenovirus (HAdV) infections in pediatric patients regarding the frequencies of major clinical symptoms and the potential disparities in laboratory and imaging parameters. Methods Following a case–control-like design, we built 72 age-matched pediatric COVID-19 and HAdV patient pairs. Their early symptoms and laboratory and imaging characteristics were then retrieved and compared. Results Fever and cough were the most common symptoms for both infections but were seen more often in HAdV than in COVID-19 patients (92% vs. 66% and 60% vs. 18%, respectively). Compared with COVID-19 patients, children with HAdV infection had statistically significantly higher values of neutrophil count, neutrophil percentage, activated partial thromboplastin time, prothrombin time, lactate dehydrogenase, C-reactive protein, procalcitonin but lower values of lymphocyte percentage, total bilirubin, potassium and sodium. Thoracic computed tomography also revealed more anomalies in HAdV patients than in COVID-19 patients (95% vs. 67%). Conclusions COVID-19 is an overall less symptomatic and less severe infection at admission compared to HAdV respiratory infection in pediatric population.

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“…Pulmonary involvement in CT scan described by Simoni et al in a systematic review, which brought together 166 children, showed mostly bilateral infiltration, between 57 and 75%, and a peripheral distribution between 12.5 and 51.7% (24). The presence of GGO was the most common finding in children with pulmonary involvement, followed by the combination of GGO and consolidation according to different series (24,25). Predominance of lower lobes and upper lobes has been described according to different series suggesting that in children there is not a clear pattern of pulmonary involvement location.…”

Section: Clinical Manifestationsmentioning

confidence: 96%

“…The chest X ray in children was abnormal up to 49.1% even some of them being asymptomatic (23). Pulmonary involvement in CT scan described by Simoni et al in a systematic review, which brought together 166 children, showed mostly bilateral infiltration, between 57 and 75%, and a peripheral distribution between 12.5 and 51.7% (24). The presence of GGO was the most common finding in children with pulmonary involvement, followed by the combination of GGO and consolidation according to different series (24,25).…”

Section: Clinical Manifestationsmentioning

confidence: 97%

Emergent Pneumonia in Children

2021

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In recent decades there have been multiple pathogens, viruses and bacteria, which have emerged as causal agents of pneumonia affecting adults, albeit less frequently, to children. For the purposes of this article we have classified emerging pathogens as follows: True emerging, to pathogens identified for the very first time affecting human population (SARS-CoV-1, SARS-CoV-2, MERS-CoV, avian influenza, and hantavirus); Re-emerging, to known pathogens which circulation was controlled once, but they have reappeared (measles, tuberculosis, antimicrobial resistant bacteria such as CA-MRSA, Mycoplasma pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and new serotypes of post-vaccine pneumococcal); and finally, those that we have called old known with new presentations, including common pathogens that, in particular condition, have changed their form of presentation (rhinovirus, and non-SARS coronavirus). We will review for each of them their epidemiology, forms of presentation, therapy, and prognosis in children compared to the adult with the aim of being able to recognize them to establish appropriate therapy, prognostics, and effective control measures.

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Chest computed tomography (CT) features in children with reverse transcription‐polymerase chain reaction (RT‐PCR)‐confirmed COVID‐19: A systematic review

Cited by 11 publications

References 65 publications

Imaging in the COVID-19 era: Lessons learned during a pandemic

Imaging in the COVID-19 era: Lessons learned during a pandemic

Comparative analysis of clinical features of SARS-CoV-2 and adenovirus infection among children

Emergent Pneumonia in Children

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