Chest CT for Breast Cancer Diagnosis

Desperito, Elise; Schwartz, Lawrence H.; Capaccione, Kathleen M.; Collins, Brian T.; Jambawalikar, Sachin; Peng, Boyu; Patrizio, Rebecca; Salvatore, Mary M.

doi:10.3390/life12111699

Cited by 11 publications

(13 citation statements)

References 19 publications

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“…Interestingly, our patient’s CT scan report did not detect the presence of any underlying breast tumor, even on retrospective review. While existing guidelines do not recommend the use of CT scans for breast cancer screening due to scant evidence of benefit and higher radiation exposure, there is some evidence that CT scans with cuts as fine as 1.25mm may be comparable to mammography in sensitivity ( 11 , 12 ). For our patient, breast cancer may have gone undetected on CT scan because the slice thickness was 3mm, possibly causing a 6 × 10 × 6mm lesion to appear small and non-specific.…”

Section: Discussionmentioning

confidence: 99%

Numb cheek syndrome in breast cancer: a case report

Tan,

Tan

2024

Front. Oncol.

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BackgroundNumb cheek syndrome, a rare corollary of numb chin syndrome, is due to infra-orbital neuropathy. It can occur in association with an underlying malignancy, which can cause neuropathy by direct malignant nerve infiltration or via a paraneoplastic mechanism. Although numb cheek syndrome has been reported in association with a variety of cancers, it has previously not been reported in association with breast cancer. We report a case of left breast cancer presenting with left numb cheek syndrome.Case presentationA 65-year-old woman presented to the Neurology clinic with a 7-month history of left cheek numbness and occasional cheek tenderness. Examination revealed slightly diminished pin-prick sensation in the left cheek and a vaguely palpable left breast lump. A magnetic resonance imaging scan of the brain showed abnormal enhancement of the left maxillary nerve at the foramen rotundum, but cerebrospinal fluid analysis was normal. Mammography, ultrasound scans, and core biopsy of the left breast confirmed the diagnosis of invasive left breast carcinoma (estrogen and progesterone receptor negative, c-erb-B2 equivocal, fluorescence in-situ hybridization negative). There was no evidence of distant metastases on computed tomography and bone scintigraphy scans. The patient underwent neoadjuvant chemotherapy (4 cycles of doxorubicin and cyclophosphamide, followed by 4 cycles of paclitaxel and carboplatin), and left breast wide excision and sentinel lymph node biopsy, and a repeat magnetic resonance imaging scan performed 2 months after surgical resection showed resolution of the left maxillary nerve enhancement. The patient’s left numb cheek symptoms improved over a course of 5 months after cancer resection but did not completely resolve.ConclusionsOur case represents the first reported left numb cheek syndrome in association with breast cancer, due to maxillary neuropathy without any discrete mass or compressive cause. To avoid delays in diagnosing malignancy, physicians and surgeons should be aware that numb cheek syndrome can occur in association with an underlying malignancy, and that breast cancer should be counted amongst the possibilities.

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Section: Discussionmentioning

confidence: 99%

Numb cheek syndrome in breast cancer: a case report

Tan,

Tan

2024

Front. Oncol.

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“…High breast density can be reliably diagnosed on chest CT [ 37 , 38 ]. Retrospective research has demonstrated that three-dimensional chest CT is sensitive and specific for breast cancer diagnosis [ 39 , 40 ]. Future prospective studies are necessary to evaluate a possible role of chest CT in breast cancer diagnosis.…”

Section: Current Imaging Practices For Breast Cancer Screening Monito...mentioning

confidence: 99%

Advances in PET/CT Imaging for Breast Cancer

Jong

Desperito

Feghali

et al. 2023

JCM

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One out of eight women will be affected by breast cancer during her lifetime. Imaging plays a key role in breast cancer detection and management, providing physicians with information about tumor location, heterogeneity, and dissemination. In this review, we describe the latest advances in PET/CT imaging of breast cancer, including novel applications of 18F-FDG PET/CT and the development and testing of new agents for primary and metastatic breast tumor imaging and therapy. Ultimately, these radiopharmaceuticals may guide personalized approaches to optimize treatment based on the patient’s specific tumor profile, and may become a new standard of care. In addition, they may enhance the assessment of treatment efficacy and lead to improved outcomes for patients with a breast cancer diagnosis.

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“…Our previous research identified breast masses on chest CT in 44 of 453 women (9.7%) ( 4 ). Benign breast masses were more likely to be small in size and have low Hounsfield units (HUs) and smooth borders; cancer was more likely to be large in size, contain high HU, and less likely to have a smooth border ( 4 ). The measurement of HU on CT was helpful for identifying cystic lesions.…”

Section: Introductionmentioning

confidence: 99%

Can Hounsfield units on chest CT characterize breast nodules as cystic or solid?

Capaccione,

Desperito,

Asiimwe

et al. 2024

Transl Breast Cancer Res

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We report the results of our retrospective analysis of the ability of standard chest computed tomography (CT) scans to correctly differentiate cystic from solid lesions. MModal Catalyst identified 27 women who had an ultrasound of the breast that was recommended because of a chest CT finding between January 1, 2010, and December 31, 2017. All images were reviewed by a radiologist fellowship trained in both breast imaging and cardiothoracic radiology (MS). Ultrasound characterization of lesion density as cystic or solid was considered the gold standard for this study. Analysis of CT scans was performed to identify lesions of interest corresponding to ultrasound abnormality; average, minimum, and maximum Hounsfield units (HUs) were measured. If masses had any solid component, they were considered solid. Twenty masses were solid, and 7 masses were cystic on ultrasound. Thirteen studies were performed without contrast and 14 were performed with contrast. On non-contrast studies, the average HU for cystic lesions was 19 compared to 38 HU for solid (P=0.007). On contrast studies, the average HU for cystic lesions was 16 compared to 53 HU for solid (P=0.002). Cystic lesions did not change with contrast significantly. Solid lesions enhanced with contrast; average HU 38 without contrast to 53 HU with contrast. Chest CT accurately diagnosed breast masses as cystic or solid with or without contrast.

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Chest CT for Breast Cancer Diagnosis

Cited by 11 publications

References 19 publications

Numb cheek syndrome in breast cancer: a case report

Numb cheek syndrome in breast cancer: a case report

Advances in PET/CT Imaging for Breast Cancer

Can Hounsfield units on chest CT characterize breast nodules as cystic or solid?

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