Chest trauma

Hansell, David M.; Lynch, David A.; McAdams, H Page; Bankier, Alexander A.

doi:10.1016/b978-0-7234-3496-2.00022-1

Cited by 5 publications

(6 citation statements)

References 315 publications

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“… 1 , 23 , 44 , 45 On chest radiographs, FLAC is seen as a peripherally located well-demarcated lesion ranging from 2 to 12 cm with peripherally placed radiopacities. 14 , 17 , 22 , 44 , 46 On computed tomography, these tumors show a heterogeneous appearance with enhancing whorls of soft tissue and non-enhancing areas of necrosis. Metastases to the same or opposite lung, or to the mediastinal compartment may also be apparent.…”

Section: Diagnosis and Clinical Characteristicsmentioning

confidence: 99%

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Comprehensive review of fetal adenocarcinoma of the lung

Ricaurte

Arrieta

Zatarain-Barrón

et al. 2018

LCTT

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Fetal adenocarcinoma of the lung (FLAC) is a rare tumor. It accounts for ~0.1%–0.5% of all pulmonary neoplasms. Due to its rarity, much of the world literature regarding FLAC comes from case reports and case series. FLAC is an adenocarcinoma resembling developing fetal lung in its pseudoglandular stage (8–16 weeks of gestation). It is distinguishable from pulmonary blastoma (PB) because it lacks the mesenchymal component which is a hallmark finding in PB. Due to differences in histopathology and clinical course, FLAC has been further categorized into low-grade (L-FLAC) and high-grade (H-FLAC) forms. L-FLAC displays low nuclear atypia and prominent morule formation and has a pure pattern. H-FLAC typically presents with at least 50% fetal morphology, and is often associated with other conventional types of lung adenocarcinoma. FLAC expresses neuroendocrine markers and thyroid transcription factor 1 in most cases. L-FLAC has an aberrant nuclear/cytoplasmic expression of β-catenin and presents mutations in this gene. H-FLAC overexpresses p53. These tumors have a very low frequency of mutations in KRAS and EGFR; it is thought that they are different from a molecular point of view to conventional lung adenocarcinomas. Approximately 25%–40% of patients are asymptomatic at presentation; most of them are incidental findings on chest radiographs. H-FLAC is more common in elderly male patients, with a heavy smoking history. L-FLAC tends to occur in young females. Patients with L-FLAC are usually diagnosed with stage I–II disease, while patients with H-FLAC usually present with a more advanced-stage disease. Poor prognostic factors for FLAC are thoracic lymphadenopathy, metastases at diagnosis, and tumor recurrence; however, the 10-year survival for FLAC is estimated at 75%.

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Section: Diagnosis and Clinical Characteristicsmentioning

confidence: 99%

“…Metastases to the same or opposite lung, or to the mediastinal compartment may also be apparent. 46 Patients with H-FLAC may present with elevated serum levels of AFP. 21 From a pathologic point of view, FLAC is difficult to diagnose preoperatively.…”

Section: Diagnosis and Clinical Characteristicsmentioning

confidence: 99%

Comprehensive review of fetal adenocarcinoma of the lung

Ricaurte

Arrieta

Zatarain-Barrón

et al. 2018

LCTT

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“…The obvious differential diagnoses are acquired total lung collapse or prior pneumonectomy. [10] CT may be required to establish the degree of underdevelopment or to differentiate agenesis from other conditions that may mimic it radiographically. [11] Pulmonary angiography shows absence of ipsilateral pulmonary artery.…”

Section: Discussionmentioning

confidence: 99%

Unilateral Pulmonary Agenesis in an Elderly Adult: A Case Report

Asoka¹,

Sunanda²,

Shivalingaiah³

et al. 2014

IOSRJDMS

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“…With progression, there is hyperinflation with bullae formation and enlargement of hilar and mediastinal lymph nodes with subsequent calcification. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

Middle Lobe Syndrome in Silicosis

Dixit

Jalutharia

Goyal

et al. 2021

Indian Journal of Occupational and Environmental Medicine

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A case of silicosis presenting as middle lobe syndrome is described in a middle-aged female. The diagnosis was confirmed by both bronchoscopy and demonstration of right middle lobe lumen narrowing and compression by calcified hilar lymph nodes on computerized tomographic scan. Simultaneous occurrence of endobronchial silicosis and bronchial stenosis by enlarged calcified peribronchial lymph nodes causing middle lobe syndrome has not been described previously as reported in this case.

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Chest trauma

Cited by 5 publications

References 315 publications

Comprehensive review of fetal adenocarcinoma of the lung

Comprehensive review of fetal adenocarcinoma of the lung

Unilateral Pulmonary Agenesis in an Elderly Adult: A Case Report

Middle Lobe Syndrome in Silicosis

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