Chest Wall Chondrosarcoma

Capps, Erin; Shiller, S. Michelle; Cheek, Scott; Oza, Umesh; Konduri, Kartik

doi:10.1080/08998280.2009.11928558

Cited by 17 publications

(26 citation statements)

References 16 publications

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“…Primary chondrosarcoma represents the third most common primary osseous malignancy but the most common primary neoplasm of the osseous chest wall, with up to 80% of cases of thoracic chondrosarcoma involving the ribs (35) (Fig 13). Pain associated with pathologic fracture is the manifesting symptom in 3%-17% of patients (36). common malignant primary osteogenic tumors in pediatric patients.…”

Section: Malignanciesmentioning

confidence: 99%

Traumatic Rib Injury: Patterns, Imaging Pitfalls, Complications, and Treatment

et al. 2017

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The ribs are frequently affected by blunt or penetrating injury to the thorax. In the emergency department setting, it is vital for the interpreting radiologist to not only identify the presence of rib injuries but also alert the clinician about organ-specific injury, specific traumatic patterns, and acute rib trauma complications that require emergent attention. Rib injuries can be separated into specific morphologic fracture patterns that include stress, buckle, nondisplaced, displaced, segmental, and pathologic fractures. Specific attention is also required for flail chest and for fractures due to pediatric nonaccidental trauma. Rib fractures are associated with significant morbidity and mortality, both of which increase as the number of fractured ribs increases. Key complications associated with rib fracture include pain, hemothorax, pneumothorax, extrapleural hematoma, pulmonary contusion, pulmonary laceration, acute vascular injury, and abdominal solid-organ injury. Congenital anomalies, including supernumerary or accessory ribs, vestigial anterior ribs, bifid ribs, and synostoses, are common and should not be confused with traumatic pathologic conditions. Nontraumatic mimics of traumatic rib injury, with or without fracture, include metastatic disease, primary osseous neoplasms (osteosarcoma, chondrosarcoma, Ewing sarcoma, Langerhans cell histiocytosis, and osteochondroma), fibrous dysplasia, and Paget disease. Principles of management include supportive and procedural methods of alleviating pain, treating complications, and stabilizing posttraumatic deformity. By recognizing and accurately reporting the imaging findings, the radiologist will add value to the care of patients with thoracic trauma. Online supplemental material is available for this article. RSNA, 2017.

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Section: Malignanciesmentioning

confidence: 99%

Traumatic Rib Injury: Patterns, Imaging Pitfalls, Complications, and Treatment

et al. 2017

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“…Chondrosarcoma is a type of bone cancer originating from cartilaginous tissue, and accounts for 25–30% of all cancers originating from the skeletal system 1–3. Chondrosarcoma is a unique type of bone cancer, as it is nonresponsive to chemotherapy or radiation therapy 2, 4–7.…”

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confidence: 99%

“…Most chondrosarcomas (80–90%) are conventional (primary) chondrosarcomas,7 which occur in the medullar cavity or at the bone surface 8. Chondrosarcoma appears most often in the long bones1, 2 but has also been found in the ribs, spine9 as well as the pelvis and scapula 1. The current method of treatment is resection of the affected bone, which is not always possible depending on numerous factors including patient comorbidities and the anatomic extent of the tumor within the skeleton and surrounding soft‐tissue 2, 5…”

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confidence: 99%

ETV5 as a regulator of matrix metalloproteinase 2 in human chondrosarcoma

Power

Mak

Singh

et al. 2012

Journal Orthopaedic Research

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Chondrosarcoma is a unique type of bone cancer in that it does not respond to chemotherapy or radiation therapy, and therefore many affected patients die from metastatic disease. Metastasis has been correlated with the upregulation of the matrix metalloproteinase (MMP) family of proteases, which can degrade extracellular components. ETV5 is a transcription factor which has shown to be overexpressed in various types of invasive tumors. We hypothesized that ETV5 regulates MMP2 in human chondrosarcoma with the protease acting as a downstream effector. Gene knock-down of ETV5 in human chondrosarcoma cells reduces MMP2 mRNA expression as well as decreased protein production and significantly decreased MMP2 activity. With plasmid transfected ETV5 upregulation, MMP2 expression is similarly upregulated at the gene expression and protein levels. Data from our bone resorption studies revealed that when a matrix metalloproteinase-2 inhibitor is added to the growth media of chondrosarcoma cells, collagen released from bone chips incubated with the cells decreased by 27%. This data suggests that ETV5 has a significant role in regulating MMP2 expression and therefore matrix resorption in human chondrosarcoma, and thus may be a targetable upstream effector of the metastatic cascade in this cancer. Keywords: bone resorption; transcription factor; gelatinase; metastasis; collagen Chondrosarcoma is a type of bone cancer originating from cartilaginous tissue, and accounts for 25-30% of all cancers originating from the skeletal system. [1][2][3] Chondrosarcoma is a unique type of bone cancer, as it is nonresponsive to chemotherapy or radiation therapy. 2,4-7 Most chondrosarcomas (80-90%) are conventional (primary) chondrosarcomas, 7 which occur in the medullar cavity or at the bone surface. 8 Chondrosarcoma appears most often in the long bones 1,2 but has also been found in the ribs, spine 9 as well as the pelvis and scapula. 1 The current method of treatment is resection of the affected bone, which is not always possible depending on numerous factors including patient comorbidities and the anatomic extent of the tumor within the skeleton and surrounding soft-tissue. 2,5 Metastasis of chondrosarcoma occurs most commonly to the lungs leading to a 50% overall 5-year survival rate 3 and a 30% 10-year survival rate. 4,6 Metastasis is, at least in part, results from the upregulation of proteases within the tumor, which degrade the surrounding tissue and cause dissemination of cancer cells into the bloodstream. 10 Of these proteases, the matrix metalloproteinase (MMP) family can degrade extracellular components including many types of gelatin, elastin, and collagen 10,11 and is commonly associated with more metastatic types of cancers. 12 Specifically, matrix metalloproteinase 2 (MMP2) has been noted to be highly expressed in pancreatic cancer, 13 which lead to poor prognoses. This is partly due to the fact that MMP2 is capable of degrading type-I collagen fragments 10,14 which is abundant in the ECM as well as at the bone surf...

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“…In paravertebral, mediastinal or thoracic outlet tumors, where neurovascular invasion is a concern, MRI offers additional information as it offers greater ability to characterizing soft-tissue structures (1). Positron emission tomography (PET) is occasionally used to identify metastatic disease and has also been suggested as a diagnostic modality to differentiate between benign chondral tissue tumors and chondrosarcoma (1,20).…”

Section: Discussionmentioning

confidence: 99%

Primary thoracic chondrosarcoma with intra‑abdominal extension in a renal transplant recipient: A case report

et al. 2020

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Primary thoracic bone tumors are relatively rare. The most common type is chondrosarcoma, accounting for up to 48% of all cases. Patients with primary thoracic bone tumors commonly present with atypical thoracic pain or a solitary palpable chest mass, which gradually develops over months to years. The bones most often affected are the ribs, scapula, costochondral junctions and the sternum. The present study presents a case of a 79 year old previous transplant recipient with a large intra-abdominally expanding chondrosarcoma originating from the left lower thoracic cage and associated vague abdomdinal symptoms. Early recognition and awareness of atypical presentations of this disease are important in to appropriately guide diagnostic evaluation and therapeutic procedures.

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Chest Wall Chondrosarcoma

Cited by 17 publications

References 16 publications

Traumatic Rib Injury: Patterns, Imaging Pitfalls, Complications, and Treatment

Traumatic Rib Injury: Patterns, Imaging Pitfalls, Complications, and Treatment

ETV5 as a regulator of matrix metalloproteinase 2 in human chondrosarcoma

Primary thoracic chondrosarcoma with intra‑abdominal extension in a renal transplant recipient: A case report

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