Chestnut Shell Extract Modulates Immune Parameters in the Rainbow Trout Oncorhynchus mykiss

Coccia, Elena; Siano, Francesco; Volpe, Maria Grazia; Varricchio, Ettore; Eroldoğan, Orhan Tufan; Paolucci, Marina

doi:10.3390/fishes4010018

Cited by 34 publications

(10 citation statements)

References 79 publications

(99 reference statements)

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“…For instance, chlorogenic acid as a phenolic compound, which presented WLP as well as various medicinal herbs, could activate macrophages through calcineurin pathway in mice cell line (Wu et al, 2004). Additionally, in vitro study demonstrated that Gallic acid derived from Chestnut shell extract could stimulate blood leukocyte of O. mykiss (Coccia, Siano, Volpe, Varricchio, Eroldogan & Paolucci, 2019). Another in another in vitro study, dihydroquercetin as a flavonoid compound derived from deodar, demonstrated promoting effects on leukocyte to modulate phagocytic activity of Sparus aurata (Awad et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Improved growth performance, serum and mucosal immunity, haematology and antioxidant capacity in pikeperch ( Sander lucioperca ) using dietary water hyacinth ( Eichhornia crassipes ) leaf powder

Rufchaei

Nedaei

Hoseinifar

et al. 2020

Aquaculture Research

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The present study was conducted to investigate the effects of dietary water hyacinth (Eichhornia crassipes) leaves powder (WLP) on growth performance, skin mucus and serum immune response, as well as antioxidant capacity of pikeperch (Sander lucioperca). During 7 weeks culture period, 120 fish (21.2 ± 0.55 g) were fed by experimental diets containing 0% (control), 0.5%, 1% and 1.5% WLP (four treatments in triplicate). At the end of the feeding trial, results revealed a significant increase in final weight (FW), weight gain (WG), daily weight gain (DWG) and specific growth rate (SGR) in fish fed with the highest value 1.5% WLP. Furthermore, increased skin mucus total immunoglobulin (Ig) level and lysozyme (LYZ) activity was noticed in 1 and 1.5% WLP groups, protease in 1.5% WLP group, and alkaline phosphatase (ALP) in 0.5 and 1% WLP groups. Haematological evaluation showed a significant rise in red blood cell (RBC) and haematocrit (HCT) at all WLP inclusion levels, while haemoglobin (Hb) value only increased in group fed by 0.5% dietary WLP. Also, remarkable increase in LYZ, protease and alternative complement (ACH50) activity were observed in WLP‐treated groups. Moreover, higher catalase (CAT) activity was detected in WLP supplemented groups, while higher superoxide dismutase (SOD) activity was detected in 0.5 and 1.5% WLP groups. However, glutathione peroxidase (GPx) activity was higher only in 0.5% WLP group. In conclusion, the present findings showed beneficial effects of water hyacinth leaves powder as a plant‐derived growth promotor and immunostimulant in the pikeperch.

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Section: Discussionmentioning

confidence: 99%

Improved growth performance, serum and mucosal immunity, haematology and antioxidant capacity in pikeperch ( Sander lucioperca ) using dietary water hyacinth ( Eichhornia crassipes ) leaf powder

Rufchaei

Nedaei

Hoseinifar

et al. 2020

Aquaculture Research

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“…Gallic acid is generally considered not dangerous, since it exerts a toxic effect only at high concentrations (Coccia, et al., 2019; Harishkumar et al., 2019; Singulani et al., 2017; Techer et al., 2015).…”

Section: Discussionmentioning

confidence: 99%

“…One‐ring phenolic compounds, such as hydroxytyrosol and GA, are readily absorbed within 15 min from incubation in leukocyte cell culture (Coccia, et al., 2019) and intestinal epithelial transplants (Coccia, et al., 2019) of rainbow trout. In agreement with these findings, our exploratory experiments highlighted the rapid in vivo effect of GA occurring within the first 30 min of treatment.…”

Section: Discussionmentioning

confidence: 99%

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Short‐term exposure to the simple polyphenolic compound gallic acid induces neuronal hyperactivity in zebrafish larvae

Annona

Tarallo

Nittoli

et al. 2020

Eur J of Neuroscience

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A growing body of evidence suggests that the biological effects of polyphenols are not restricted to antioxidant activity, but they exert a wide range of modulatory effects on metabolic pathways, cellular signaling and gene expression. In this study, we tested the minimum safe concentration of gallic acid (GA) in 72 hpf zebrafish larvae in order to evaluate the effects on the central nervous system and the behavioral response. We showed that a short exposure (30 min) induces the depletion of the two main excitatory and inhibitory neurotransmitters, Glu and GABA, respectively, in the larval nervous system. The acute impairment of GABAergic‐glutamatergic balance was paralleled by an increase of the fosab neuronal activity marker in specific brain areas, such as the forebrain, olfactory bulbs, pallial area, ventral midbrain, tegmentum, and the medulla oblongata ventral area. The neuronal excitation was mirrored by the increased cumulative motor response. The inhibition of the olfactory epithelium with brief cadmium exposition suggests a direct involvement of olfaction in the larvae response to GA. Our results demonstrate that a brief exposure to GA induces motoneuronal hyperexcitability in zebrafish. The behavioral response was probably elicited through the activation of an odorous, or chemical, stimulus. The specificity of the activated neuronal territories suggests the involvement of additional signaling pathways. Although the underlying molecular mechanisms remain to be elucidated, our data support the hypothesis that GA acts as an excitatory molecule, capable of inducing a specific nerve response. These results offer a new vision on potential effects of GA.

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“…For example, chestnut shell hydroalcoholic extracts tested on several human cell lines were suggested to display potential anti-angiogenic and anti-inflammatory effects [ 4 ]. When assayed on trout blood and intestinal leukocytes, they also elicited a stimulatory response of the immune system against possible infectious agents [ 5 ]. Several studies on rat models of diabetes fed with chestnut extracts demonstrated a diet-dependent increase of pancreatic cell viability [ 6 ] and a corresponding cytoprotective response against hepatorenal injury [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Polyphenol Profiling of Chestnut Pericarp, Integument and Curing Water Extracts to Qualify These Food By-Products as a Source of Antioxidants

et al. 2021

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Plant polyphenols have beneficial antioxidant effects on human health; practices aimed at preserving their content in foods and/or reusing food by-products are encouraged. The impact of the traditional practice of the water curing procedure of chestnuts, which prevents insect/mould damage during storage, was studied to assess the release of polyphenols from the fruit. Metabolites extracted from pericarp and integument tissues or released in the medium from the water curing process were analyzed by matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) and electrospray-quadrupole-time of flight-mass spectrometry (ESI-qTOF-MS). This identified: (i) condensed and hydrolyzable tannins made of (epi)catechin (procyanidins) and acid ellagic units in pericarp tissues; (ii) polyphenols made of gallocatechin and catechin units condensed with gallate (prodelphinidins) in integument counterparts; (iii) metabolites resembling those reported above in the wastewater from the chestnut curing process. Comparative experiments were also performed on aqueous media recovered from fruits treated with processes involving: (i) tap water; (ii) tap water containing an antifungal Lb. pentosus strain; (iii) wastewater from a previous curing treatment. These analyses indicated that the former treatment determines a 6–7-fold higher release of polyphenols in the curing water with respect to the other ones. This event has a negative impact on the luster of treated fruits but qualifies the corresponding wastes as a source of antioxidants. Such a phenomenon does not occur in wastewater from the other curing processes, where the release of polyphenols was reduced, thus preserving the chestnut’s appearance. Polyphenol profiling measurements demonstrated that bacterial presence in water hampered the release of pericarp metabolites. This study provides a rationale to traditional processing practices on fruit appearance and qualifies the corresponding wastes as a source of bioactive compounds for other nutraceutical applications.

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Chestnut Shell Extract Modulates Immune Parameters in the Rainbow Trout Oncorhynchus mykiss

Cited by 34 publications

References 79 publications

Improved growth performance, serum and mucosal immunity, haematology and antioxidant capacity in pikeperch ( Sander lucioperca ) using dietary water hyacinth ( Eichhornia crassipes ) leaf powder

Improved growth performance, serum and mucosal immunity, haematology and antioxidant capacity in pikeperch ( Sander lucioperca ) using dietary water hyacinth ( Eichhornia crassipes ) leaf powder

Short‐term exposure to the simple polyphenolic compound gallic acid induces neuronal hyperactivity in zebrafish larvae

Polyphenol Profiling of Chestnut Pericarp, Integument and Curing Water Extracts to Qualify These Food By-Products as a Source of Antioxidants

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