Chewing fails to induce oral bacteraemia in patients with periodontal disease

Murphy, AM; Daly, CG; Mitchell, DH; Stewart, Douglas A.; Curtis, Brad

doi:10.1308/135576107779398066

Cited by 8 publications

(35 citation statements)

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“…Similar results were observed in a later study where postchewing bacteremia was detected in 20% of subjects who had evidence of periodontal inflammation, while none was detected in periodontally healthy subjects and subjects with gingivitis (i.e., superficial inflammation of the gums but not the deep periodontal tissues) (48). However, Murphy and coworkers (89) showed in a controlled study that chewing failed to seed detectable numbers of bacterial species into the bloodstream at different time intervals, irrespective of periodontal health status. Interestingly, in a parallel approach, Geerts et al (49) noted significantly raised levels of bacterial endotoxins in subjects with chronic periodontitis, as assessed by the Limulus amoebocyte lysate assay.…”

Section: Chewingsupporting

confidence: 81%

Microbiology of Odontogenic Bacteremia: beyond Endocarditis

et al. 2009

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SUMMARY The human gingival niche is a unique microbial habitat. In this habitat, biofilm organisms exist in harmony, attached to either enamel or cemental surfaces of the tooth as well as to the crevicular epithelium, subjacent to a rich vascular plexus underneath. Due to this extraordinary anatomical juxtaposition, plaque biofilm bacteria have a ready portal of ingress into the systemic circulation in both health and disease. Yet the frequency, magnitude, and etiology of bacteremias due to oral origin and the consequent end organ infections are not clear and have not recently been evaluated. In this comprehensive review, we address the available literature on triggering events, incidence, and diversity of odontogenic bacteremias. The nature of the infective agents and end organ infections (other than endocarditis) is also described, with an emphasis on the challenge of establishing the link between odontogenic infections and related systemic, focal infections.

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Section: Chewingsupporting

confidence: 81%

Microbiology of Odontogenic Bacteremia: beyond Endocarditis

et al. 2009

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“…It is not clear why low-level of transient bacteremia may occur in the absence of therapeutic intervention [18], [16] and clinical relevance of such condition remains unknown. The “pumping action” created by movement of the tooth within the socket [66] (bruxism) should be investigated. In an immune person, the nonspecific host defense (phagocytes and complement) provides the first line protection.…”

Section: Discussionmentioning

confidence: 99%

Dissemination of Periodontal Pathogens in the Bloodstream after Periodontal Procedures: A Systematic Review

et al. 2014

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BackgroundTo date, there is no compilation of evidence-based information associating bacteremia and periodontal procedures. This systematic review aims to assess magnitude, duration, prevalence and nature of bacteremia caused by periodontal procedures.Study DesignSystematic ReviewTypes of Studies ReviewedMEDLINE, EMBASE and LILACS databases were searched in duplicate through August, 2013 without language restriction. Observational studies were included if blood samples were collected before, during or after periodontal procedures of patients with periodontitis. The methodological quality was assessed in duplicate using the modified Newcastle-Ottawa scale (NOS).ResultsSearch strategy identified 509 potentially eligible articles and nine were included. Only four studies demonstrated high methodological quality, whereas five were of medium or low methodological quality. The study characteristics were considered too heterogeneous to conduct a meta-analysis. Among 219 analyzed patients, 106 (49.4%) had positive bacteremia. More frequent bacteria were S. viridans, A. actinomycetemcomitans P. gingivalis, M. micros and species Streptococcus and Actinomyces, although identification methods of microbiologic assays were different among studies.Clinical ImplicationsAlthough half of the patients presented positive bacteremia after periodontal procedures, accurate results regarding the magnitude, duration and nature of bacteremia could not be confidentially assessed.

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“…57 This has led to the adop tion of prophylactic measures to prevent can produce sufficient bacteraemia to cause an endocarditis is equivocal. 58 The consensus is that the majority of bacte rial infections of prosthetic devices are of non-oral origin. 59 …”

Section: Infective Endocarditis (Ie)mentioning

confidence: 99%