Chewing gum of antimicrobial decapeptide (KSL) as a sustained antiplaque agent: Preformulation study

Na, Dong Hee; Faraj, Jabar A.; Çapan, Yılmaz; Leung, Kai P.; DeLuca, Patrick P.

doi:10.1016/j.jconrel.2005.05.027

Cited by 44 publications

(34 citation statements)

References 24 publications

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“…KSL and its analogues were analyzed by reversed-phase HPLC using a Prosphere C-18 analytical column (4.6 Â 250 mm, Alltech, Deerfield, IL) with a Prosphere C-18 guard column (4.6 Â 7.5 mm, Alltech, Deerfield, IL) with a slight modification of a HPLC method described previously (12). A gradient elution was performed with mobile phase A (0.1% TFA in water) and mobile phase B (0.1% TFA in acetonitrile).…”

Section: Hplc Analysismentioning

confidence: 99%

“…The chewing gum formulations were prepared following a procedure described previously (12). The gum base was heated at a temperature between 50 and 60-C for melting.…”

Section: Chewing Gum Preparationmentioning

confidence: 99%

“…However, chlorhexidine is known to have several disadvantages which include its bitter taste, impairment of taste perception, reversible staining of teeth and tongue, and interaction with surfactants in the toothpastes (11). Recently, KSL was reported to be a promising antimicrobial agent in a chewing gum formulation (12). The chewing gum formulation showed a desirable sustained release profile over 20 to 40 min of chewing time.…”

Section: Introductionmentioning

confidence: 99%

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Stability of Antimicrobial Decapeptide (KSL) and Its Analogues for Delivery in the Oral Cavity

Faraj

Çapan

et al. 2007

Pharm Res

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Section: Hplc Analysismentioning

confidence: 99%

“…The chewing gum formulations were prepared following a procedure described previously (12). The gum base was heated at a temperature between 50 and 60-C for melting.…”

Section: Chewing Gum Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Stability of Antimicrobial Decapeptide (KSL) and Its Analogues for Delivery in the Oral Cavity

Faraj

Çapan

et al. 2007

Pharm Res

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“…Notably, KSL is not cytotoxic to mouse erythrocytes, and concentrations up to 1 mg/mL, or 160 times the effective bacteriocidal concentration, do not compromise the membranes of human gingival fibroblasts. KSL is optimally stable at pH 4.0 and 25°C, although accelerated degradation occurs at increasing pH (7.4 and 9.0) and temperatures (37°C and 55°C) [156]. KSL readily adsorbs to hydroxyapatite disks treated with whole human saliva and demonstrates a favorable release profiles over 20 min from a chewing gum formulation in vitro and in vivo [156].…”

Section: Synthetics Conjugates and Peptide Mimeticsmentioning

confidence: 99%

“…KSL is optimally stable at pH 4.0 and 25°C, although accelerated degradation occurs at increasing pH (7.4 and 9.0) and temperatures (37°C and 55°C) [156]. KSL readily adsorbs to hydroxyapatite disks treated with whole human saliva and demonstrates a favorable release profiles over 20 min from a chewing gum formulation in vitro and in vivo [156]. However, KSL is substantially degraded by both human saliva and gastric fluid after only minutes of exposure [156].…”

Section: Synthetics Conjugates and Peptide Mimeticsmentioning

confidence: 99%

Antibacterial Peptides: Opportunities for the Prevention and Treatment of Dental Caries

Pepperney

Chikindas

2011

Probiotics & Antimicro. Prot.

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Dental caries is a multifactorial disease that is a growing and costly global health concern. The onset of disease is a consequence of an ecological imbalance within the dental plaque biofilm that favors specific acidogenic and aciduric caries pathogens, namely Streptococcus mutans and Streptococcus sobrinus. It is now recognized by the scientific and medical community that it is neither possible nor desirable to totally eliminate dental plaque. Conversely, the chemical biocides most commonly used for caries prevention and treatment indiscriminately attack all plaque microorganisms. These treatments also suffer from other drawbacks such as bad taste, irritability, and staining. Furthermore, the public demand for safe and natural personal hygiene products continues to rise. Therefore, there are opportunities that exist to develop new strategies for the treatment of this disease. As an alternative to conventional antibiotics, antibacterial peptides have been explored greatly over the last three decades for many different therapeutic uses. There are currently tens of hundreds of antibacterial peptides characterized across the evolutionary spectrum, and among these, many demonstrate physical and/or biological properties that may be suitable for a more targeted approach to the selective control or elimination of putative caries pathogens. Additionally, many peptides, such as nisin, are odorless, colorless, and tasteless and do not cause irritation or staining. This review focuses on antibacterial peptides for their potential role in the treatment and prevention of dental caries and suggests candidates that need to be explored further. Practical considerations for the development of antibacterial peptides as oral treatments are also discussed.

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Topical Oral Cavity Pharmacokinetic Modeling of a Stannous Fluoride Dentifrice: An Unusual Two Compartment Model

Scott

Coggan

Cruze

et al. 2009

Journal of Pharmaceutical Sciences

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Chewing gum of antimicrobial decapeptide (KSL) as a sustained antiplaque agent: Preformulation study

Cited by 44 publications

References 24 publications

Stability of Antimicrobial Decapeptide (KSL) and Its Analogues for Delivery in the Oral Cavity

Stability of Antimicrobial Decapeptide (KSL) and Its Analogues for Delivery in the Oral Cavity

Antibacterial Peptides: Opportunities for the Prevention and Treatment of Dental Caries

Topical Oral Cavity Pharmacokinetic Modeling of a Stannous Fluoride Dentifrice: An Unusual Two Compartment Model

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