Chiari-Like Malformation in Dogs

Marino, Dominic J.; Dewey, Curtis W.

doi:10.1007/978-1-4614-6369-6_11

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…One hundred twenty-one consecutive client-owned CKCS from 2006-2016 with CM and SM con rmed by whole body MRI that underwent FMD with cranioplasty and durectomy [36] were included in the study. Informed written consent was obtained from all owners of the animals in this study.…”

Section: Patient Populationmentioning

confidence: 99%

Histologic findings of the dura mater at the level of the foramen magnum in 121 CKCS with Chiari-like malformation

Holdsworth

Marino

Loughin

et al. 2021

Preprint

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Background: To describe histopathologic features found in dural biopsies of Cavalier King Charles Spaniels (CKCS) with Chiari-like malformation (CM) and identify any associations between age, duration of clinical signs, syrinx location or syringomyelia (SM) and quality of life (QOL). The medical records of 121 consecutive client owned CKCS with CM and SM, confirmed by whole body magnetic resonance imaging (MRI), that underwent foramen magnum decompression (FMD) with cranioplasty and durectomy with biopsy from 2006 to 2016 were retrospectively reviewed. Dura biopsies were submitted to a board-certified veterinary pathologist for histopathologic interpretation. The chi-square test was used to analyze associations between diagnosis and categorical variables. For continuous measures, the Kruskal-Wallis non-parametric test was used to compare distributions across pathology categories. A result was considered statistically significant at the P<0.05 level of significance. Results: The mean age, duration of pre-surgical clinical signs, and pre-operative QOL (1-5 scale) were 44.27 months, 44.78 weeks, and 2.72 respectively. Syringomyelia was found in the cervical region only in thirty-nice of one hundred twenty-one (32.23%) of dogs, in the cervical and thoracic region only in seventeen of one hundred twenty-one (14.05%) of dogs, and in the cervical, thoracic and lumbar region combined in sixty-five of one hundred twenty-one (53.72%) of dogs. Sixty-six of one hundred twenty-one (54.55%) dural biopsy specimens had histopathology changes; fifty-five (45.45%) did not. Forty-three of one hundred twenty-one (35.54%) dural biopsy specimens had osseous metaplasia, sixteen of one hundred twenty-one (13.22%) had evidence of fibrosis, four of one hundred twenty-one (3.31%) had arachnoid hyperplasia, and three of one hundred twenty-one (2.48%) had evidence of mineralization. Conclusions: The majority of dogs with CM were found to have histopathologic changes in the dura at the time of FMD cranioplasty was performed. These dural changes can be observed in dogs experiencing clinical signs for a time period as short as four weeks prior to presentation. Histopathologic changes were not associated with age, breed, duration of clinical signs, the location of syringomyelia or preoperative QOL. The influence of histopathologic changes on long term prognosis in dogs without dural decompression is unknown since all dogs in this study had dural resection.

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Section: Patient Populationmentioning

confidence: 99%

Histologic findings of the dura mater at the level of the foramen magnum in 121 CKCS with Chiari-like malformation

Holdsworth

Marino

Loughin

et al. 2021

Preprint

Self Cite

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“…(Dewey et al, 2005;Marino et al, 2012). It has been reported as a canine analogue of the human condition Chiari malformation type I (Marino et al, 2013). In the cavalier King Charles spaniel (CKCS), the prevalence of CLM approaches 95% (Dewey and Rusbridge, 2008).…”

Section: Samenvattingmentioning

confidence: 99%

MRI-gebaseerde morfometrische analyse gerelateerd aan chiari-achtige malformatie bij brachycefale hondenrassen

Gordon¹,

Marioni‐Henry²,

Batle³

et al. 2017

Vlaams Diergeneeskundig Tijdschrift

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The aim of this study was to investigate potential differences and correlations between brain and skull morphology and the clinical signs of brachycephalic dogs with and without Chiari-like malformation (CLM). Various measurements were derived from magnetic resonance images of the brain and craniocervical junction of thirty brachycephalic dogs in a flexed-neck position. Each dog was assigned a clinical grade. The distance from the planum of the foramen magnum to the pons was significantly reduced, providing evidence of craniocephalic disproportion similar to human patients with Chiari malformation type I. Cerebral length relative to cranial length was significantly increased in dogs with CLM compared with control dogs, supporting the hypothesis that CLM is governed by a global overcrowding of the brain, dissimilar to the human condition. Significant correlations were identified between these measurements and the extent of cerebellar herniation. No significant differences or correlations were identified with clinical grade. This is the first described morphometric analysis to use a strictly brachycephalic study population inclusive of a control group free from CLM.

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Chiari-Like Malformation in Dogs

Cited by 2 publications

References 41 publications

Histologic findings of the dura mater at the level of the foramen magnum in 121 CKCS with Chiari-like malformation

Histologic findings of the dura mater at the level of the foramen magnum in 121 CKCS with Chiari-like malformation

MRI-gebaseerde morfometrische analyse gerelateerd aan chiari-achtige malformatie bij brachycefale hondenrassen

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