Chiasma Frequency and Maternal Age in Mammals

Henderson, Scott; Edwards, Robert G.

doi:10.1038/218022a0

Cited by 408 publications

(195 citation statements)

References 28 publications

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“…Piers et al ., 1998), a more common pattern may be the relative constancy of metabolic rate that we observed here. An enormous range of physiological processes decline with age, from lung capacity (Bode et al ., 1976) to running speed (Moore, 1975) to oocyte chiasma frequency (Henderson & Edwards, 1968). We might expect that metabolic rates would decline with age in fruit flies for two reasons.…”

Section: The Rate Of Living Theorymentioning

confidence: 99%

Age‐specific metabolic rates and mortality rates in the genusDrosophila

Promislow

Haselkorn

2002

Aging Cell

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SummaryEarly theories of aging suggested that organisms with relatively high metabolic rates would live shorter lives. Despite widespread tests of this 'rate of living' theory of aging, there is little empirical evidence to support the idea. A more fine-grained approach that examined age-related changes in metabolic rate over the life span could provide valuable insight into the relationship between metabolic rate and aging. Here we compare age-related metabolic rate (measured as CO 2 production per hour) and age-related mortality rate among five species in the genus Drosophila . We find no evidence that longer-lived species have lower metabolic rates. In all five species, there is no clear evidence of an age-related metabolic decline. Metabolic rates are strikingly constant throughout the life course, with the exception of females of D. hydei , in which metabolic rates show an increase over the first third of the life span and then decline. We argue that some physiological traits may have been shaped by such strong selection over evolutionary time that they are relatively resistant to the decline in the force of selection that occurs within the life time of a single individual. We suggest that comparisons of specific traits that do not show signs of aging with those traits that do decline with age could provide insight into the aging process.

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Section: The Rate Of Living Theorymentioning

confidence: 99%

Age‐specific metabolic rates and mortality rates in the genusDrosophila

Promislow

Haselkorn

2002

Aging Cell

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“…The first specific evidence related to this issue was the observation that oocytes from older mice display a decrease in number of chiasmata, which might predispose the germ line cells to non-disjunction in meiosis I. 75 Studies using polymorphic markers have provided supportive findings showing that the number of recombination events in chromosome 21 is reduced in human trisomy 21 cases. 76,77 The 'production line hypothesis' has also been entertained, that is, there is a gradient in the fetal ovary such that the first-formed oocytes have a higher frequency of chiasmata than those formed at a later stage, and that the oocytes ovulate in the same order in which they enter meiosis.…”

Section: Age-related Chromosomal Non-disjunction In Meiosis Imentioning

confidence: 99%

“…76,77 The 'production line hypothesis' has also been entertained, that is, there is a gradient in the fetal ovary such that the first-formed oocytes have a higher frequency of chiasmata than those formed at a later stage, and that the oocytes ovulate in the same order in which they enter meiosis. 75 Extensive studies using polymorphic markers have additionally revealed that the sites of recombination have a distal location bias in cases of trisomy 21. 78 More detailed analyses have further demonstrated that distal recombination is a risk only in younger mothers, but that recombination pattern is not atypical in trisomy 21 offspring of an older mother.…”

Section: Age-related Chromosomal Non-disjunction In Meiosis Imentioning

confidence: 99%

Recent advance in our understanding of the molecular nature of chromosomal abnormalities

et al. 2009

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The completion of the human genome project has enabled researchers to characterize the breakpoints for various chromosomal structural abnormalities including deletions, duplications or translocations. This in turn has shed new light on the molecular mechanisms underlying the onset of gross chromosomal rearrangements. On the other hand, advances in genetic manipulation technologies for various model organisms has increased our knowledge of meiotic chromosome segregation, errors which, contribute to chromosomal aneuploidy. This review focuses on the current understanding of germ line chromosomal abnormalities and provides an overview of the mechanisms involved. We refer to our own recent data and those of others to illustrate some of the new paradigms that have arisen in this field. We also discuss some perspectives on the sexual dimorphism of some of the pathways that leads to these chromosomal abnormalities.

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“…It is widely held that chromosome pairing, synapsis, and crossing over are important events for normal disjunction and segregation and that aberrant synapsis/recombination could lead to aneuploidy (14)(15)(16). For example, studies in Drosophila (17), mice (18), and humans with trisomy 21 (19) imply that a low level of recombination results in chromosomal nondisjunction.…”

Section: Numerical Chromosome Anomaliesmentioning

confidence: 99%

Genetic Anomalies in Mammalian Germ Cells and Their Significance for Human Reproductive and Developmental Risk

Dellarco¹

1993

Environmental Health Perspectives

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Chiasma Frequency and Maternal Age in Mammals

Cited by 408 publications

References 28 publications

Age‐specific metabolic rates and mortality rates in the genusDrosophila

Age‐specific metabolic rates and mortality rates in the genusDrosophila

Recent advance in our understanding of the molecular nature of chromosomal abnormalities

Genetic Anomalies in Mammalian Germ Cells and Their Significance for Human Reproductive and Developmental Risk

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