Chicken albumin exhibits natural resistance to glycation

Zuck, Jessica; Borges, Chad R.; Braun, Eldon J.; Sweazea, Karen L.

doi:10.1016/j.cbpb.2016.10.003

Cited by 11 publications

(3 citation statements)

References 30 publications

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“…However, the logarithmic nature of the relationship, together with a scaling factor lower than 1, suggests that species with higher plasma glucose levels exhibit relatively greater resistance to glycation. This finding aligns with previous research indicating that in vitro glycation levels of chicken albumin increase at a slower rate than those of human albumin when glucose concentration is elevated [71]. Moreover, these levels are consistently lower than those of bovine serum albumin regardless of glucose concentration and exposition time [34].…”

Section: Bird Glycemia Appears Affected By Body Mass and Maximum Life...supporting

confidence: 91%

Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

Moreno-Borrallo,

Jaramillo-Ortiz,

Schaeffer-Reiss

et al. 2024

Preprint

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The pace of life hypothesis (POL) suggests that organisms’ life history, physiological and behavioural traits should co-evolve. In this context, glycaemia (i.e., blood glucose levels) and its consequences to ageing through its reaction with proteins and other compounds (i.e. glycation) constitute physiological traits which remain under-investigated in an evolutionary comparative framework, notably in relation to life history traits and ecological factors. Although their blood glucose levels are twice as high as in mammals, birds live longer when accounting for their body mass. We thus performed a comparative analysis on glucose and albumin glycation rates on 87 bird species from 22 orders, in relation to life history traits (body mass, clutch mass, maximum lifespan and developmental time) and diet. Glucose levels correlated positively with albumin glycation rates in a non-linear fashion, suggesting resistance to glycation in species with higher glucose levels. Plasma glucose levels decreased with increasing body mass and increased with maximum lifespan before reaching a plateau. Finally, terrestrial carnivores showed higher albumin glycation compared to omnivores. Our results open an important new avenue of research to help us to better understand the striking condition of hyperglycaemic yet long-lived birds.

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Section: Bird Glycemia Appears Affected By Body Mass and Maximum Life...supporting

confidence: 91%

Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

Moreno-Borrallo,

Jaramillo-Ortiz,

Schaeffer-Reiss

et al. 2024

Preprint

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“…This site specificity obviously depends on the amino acid composition of a given protein, but also and above all, on its multidimensional conformation, with theoretically glycatable amino acids being either exposed at the surface or, on the contrary, inaccessible because hidden. Thus, the lower number of lysines in chicken albumin and the fact that most of these residues are located in the inner part of the protein (only one lysine on the surface) seem to explain why it is glycated at a lower rate than bovine or human albumin (three lysines on the surface) when exposed to the same increasing concentrations of glucose [ 102 , 103 ]. Moreover, the presence of certain amino acids (such as aspartic acid or specific binding sites for phosphate or phosphorylated molecules) in the neighbourhood of the preferential glycation sites also seems to be of importance [ 104 ].…”

Section: Mechanisms Of Glycation Resistance That Need To Be Explored ...mentioning

confidence: 99%

Glycation resistance and life-history traits: lessons from non-conventional animal models

Duval,

Criscuolo,

Bertile

2024

Biol. Lett.

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Glycation reactions play a key role in the senescence process and are involved in numerous age-related pathologies, such as diabetes complications or Alzheimer’s disease. As a result, past studies on glycation have mostly focused on human and laboratory animal models for medical purposes. Very little is known about glycation and its link to senescence in wild animal species. Yet, despite feeding on high-sugar diets, several bat and bird species are long-lived and seem to escape the toxic effects of high glycaemia. The study of these models could open new avenues both for understanding the mechanisms that coevolved with glycation resistance and for treating the damaging effects of glycations in humans. Our understanding of glycaemia’s correlation to proxies of animals’ pace of life is emerging in few wild species; however, virtually nothing is known about their resistance to glycation, nor on the relationship between glycation, species’ life-history traits and individual fitness. Our review summarizes the scarce current knowledge on the links between glycation and life-history traits in non-conventional animal models, highlighting the predominance of avian research. We also investigate some key molecular and physiological parameters involved in glycation regulation, which hold promise for future research on fitness and senescence of individuals.

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“…Despite the high plasma glucose concentrations and documented insulin resistance (Braun & Sweazea, 2008;Sweazea & Braun, 2005), birds do not develop any 2 of 6 | MOORADIAN AND HAAS known complications of diabetes, and they outlive mammals of comparable body size (Braun & Sweazea, 2008;Holmes et al, 2001;Speakman, 2005). This natural resistance to hyperglycemia-related tissue damage has been attributed partly to reduced protein glycation (Zuck et al, 2017), higher levels of carbonyl-scavenging amino acids in plasma (Szwergold and Miller, 2014), and lack of the gene for the receptor for advanced glycation endproducts (RAGE) (Sessa et al, 2014). However, the absence of RAGE in birds has yet to be confirmed at the protein level and species-specific differences in defenses against oxidative stress may also be important for the ability of birds to live with chronic relative hyperglycemia (Klandorf et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Reduced cellular glucose transport confers natural protection against dextrose‐induced superoxide generation and endoplasmic reticulum stress in domestic hen

Mooradian

Haas

2021

Physiol Rep

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Normal blood glucose levels in avian species are two to fourfold higher than that in humans and the higher blood glucose levels in birds do not cause adverse effects.Endothelial cells isolated from the aorta of the domestic hen (Gallus gallus domesticus) and chicken aortic smooth muscle cells (CAOSMC) were compared to human coronary artery endothelial cells (HCAEC) and human primary aortic smooth muscle cells (HASMC). Superoxide (SO) generation was measured using a superoxidereactive probe. ER stress was measured using the placental alkaline phosphatase assay (ES-TRAP). Glucose transport kinetics were determined using the 3 H-2-deoxyglucose tracer. Dextrose-induced SO generation and ER stress were significantly blunted in avian endothelial cells compared to human cells. The Vmax of glucose uptake (in nmoles/mg protein/min) in avian endothelial cells (0.0018 ± 0.0001) and smooth muscle cells (0.0015 ± 0.0007) was approximately 18-25 fold lower compared to the Vmax in HCAEC (0.033 ± 0.0025) and HASMC (0.038 ± 0.004) (all p < 0.0001).The Michaelis-Menten constant (Km) of transport was also significantly different (p < 0.0001) in avian species. The relative resistance of avian cells to dextroseinduced oxidative stress and ER stress is mostly the result of reduced cellular dextrose transport. K E Y W O R D Schicken aortic endothelial cells, endoplasmic reticulum stress, glucose transport, human coronary artery endothelial cell, oxidative stress How to cite this article: Mooradian AD, Haas MJ. Reduced cellular glucose transport confers natural protection against dextrose-induced superoxide generation and endoplasmic reticulum stress in domestic hen.

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Chicken albumin exhibits natural resistance to glycation

Cited by 11 publications

References 30 publications

Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis

Glycation resistance and life-history traits: lessons from non-conventional animal models

Reduced cellular glucose transport confers natural protection against dextrose‐induced superoxide generation and endoplasmic reticulum stress in domestic hen

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