Chicken infectious anaemia virus infections in chickens in northern Vietnam: epidemiological features and genetic characterization of the causative agent

Huynh, Le Thi My; Nguyen, Van Giap; Duc, Luc Do; Dao, T.D.; Le, Truong Van; Vu, Ngoc Thi; Cao, Phuong Thi Bich

doi:10.1080/03079457.2019.1637821

Cited by 18 publications

(12 citation statements)

References 47 publications

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“…After its first report in 1979, in Japan ( 34 ), CAV has been detected worldwide. The diversity of CAV strains in different countries has been reported previously ( 35 – 37 ). In recent years, CAV infections have been detected in Guangdong, Shandong, and Heilongjiang provinces of China ( 2 , 16 , 28 , 38 , 39 ).…”

Section: Discussionsupporting

confidence: 55%

Genomic Sequence and Pathogenicity of the Chicken Anemia Virus Isolated From Chicken in Yunnan Province, China

et al. 2022

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Chicken anemia virus (CAV), which has been reported in many countries, causes severe anemia and immunosuppression in chickens. In this study, a CAV strain YN04 belonging to genotype A was first identified from infected chickens in Yunnan province, China. Moreover, the animal infection experiments further confirmed that the strain YN04 is a highly pathogenic strain, which can cause 86.67% mortality in chickens in the infection group. The mean death time of infected chickens was 13.1 days post infection (dpi). CAV infection induced severe anemia with significant decrease in packed cell volume (PCV), and serious atrophy and lesion of thymus and bursa with high viral load at 14 dpi. Besides, CAV infection caused a sharp decrease in chicken body weight and immune organ indices including the ratio of thymus or bursa to body weight at 21 dpi, which displayed the potential immunosuppression state at this stage. These findings enrich the epidemiological data on CAV and may provide information for preventing its further spread in Yunnan province, China.

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Section: Discussionsupporting

confidence: 55%

Genomic Sequence and Pathogenicity of the Chicken Anemia Virus Isolated From Chicken in Yunnan Province, China

et al. 2022

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“…The molecular epidemiology of CAV had been previously described, and several genotypes of CAV had been determined by phylogenetic analysis ( 15 , 16 , 19 , 29 , 30 ). In this study, phylogenetic analysis using full-length CAV genomic sequences was performed according to previous studies.…”

Section: Discussionmentioning

confidence: 99%

Genomic Characterization of Chicken Anemia Virus in Broilers in Shandong Province, China, 2020–2021

Liu

Li²,

Yin

et al. 2022

Front. Vet. Sci.

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Chicken infectious anemia (CIA), caused by chicken anemia virus (CAV), is an immunosuppressive disease characterized by growth retardation, aplastic anemia, lymphoid depletion, and immunodepression in young chickens. In this study, 33 CAV strains were isolated from broilers in Shandong Province during 2020–2021. Phylogenetic analysis of full-length genome sequences showed that most CAV strains isolated in this study were scattered across different branches, but mainly clustered in two genotypes, indicating a certain regional characteristic. Analysis of VP1 protein identified several amino acid substitutions which were relevant with the virulence and virus spread efficiency. Interestingly, four putative DNA recombination events were detected in the genomes of novel isolated CAV strains. In summary, this study demonstrated a genomic diversity of CAV in broilers isolated in Shandong Province during 2020–2021, and provided information for the further study of CAV molecular epidemiology and viral evolution.

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“…For example, 32 CIAV sequences were identified in 2010 in South Korea ( 13 ). In India, 351 serum samples were positive out of 404 (86.88%) collected from chicken flocks in 11 poultry farms ( 14 ), and in northern Vietnam, there were 74 positive tests from 119 samples (62.2%) collected from 64 farms ( 15 ). In China, CIAV has been detected in poultry farms from most provinces, and has been successfully isolated both from live non-CIAV vaccines and specific pathogen free (SPF) chickens ( 16 ), which may explain the reason for the CIAV contamination found in the field.…”

Section: Introductionmentioning

confidence: 99%

Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China

et al. 2022

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Chicken infectious anemia (CIA) is an immunosuppressive disease caused by the chicken infectious anemia virus (CIAV) resulting in heavy economic losses once an outbreak is established. This study conducted a systematic analysis of the epidemiology and pathology of CIA in Henan province, China. A total of 437 clinical tissue samples and 120 poultry disease-related live attenuated vaccines were collected during 2017–2020; of which 45 were positive for CIAV nucleic acid, with a positive rate of 8.08%. Our results showed that genome sequence similarity among a total of 12 CIAV isolates was high, and ranged from 97.1 to 99.3%, and their similarity to the vaccine strains Cux-1 and Del-Ros ranged from 97.8 to 98.6%. However, There were mutations in the locus of the major capsid proteins VP1, VP2, and VP3 among all isolates. The subsequent sequence analysis indicated that the isolates of HN-4 and HN-8 showed genetic recombination and follow up animal experiments revealed that HN-4 might be a pathogenic strain. Our results reveal that both field infection and non-CIAV vaccines contamination promote the epidemiology of CIAV in China and some dominant epidemic viruses have undergone recombination and evolution. This study provides important information to help with the prevention and control of CIAV in the poultry industry.

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Chicken infectious anaemia virus infections in chickens in northern Vietnam: epidemiological features and genetic characterization of the causative agent

Cited by 18 publications

References 47 publications

Genomic Sequence and Pathogenicity of the Chicken Anemia Virus Isolated From Chicken in Yunnan Province, China

Genomic Sequence and Pathogenicity of the Chicken Anemia Virus Isolated From Chicken in Yunnan Province, China

Genomic Characterization of Chicken Anemia Virus in Broilers in Shandong Province, China, 2020–2021

Molecular Epidemiology and Pathogenic Characterization of Novel Chicken Infectious Anemia Viruses in Henan Province of China

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