Chicken Intestinal L Cells and Glucagon-like Peptide-1 Secretion

Hiramatsu, Kohzy

doi:10.2141/jpsa.0190003

Cited by 17 publications

(15 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These neurotensin-immunoreactive cells have a long cytoplasmic process in contact with the intestinal lumen as mentioned by Atoji et al (1994) . This type of enteroendocrine cells is classified as “open-type” ( Hiramatsu, 2019 ). Open-type enteroendocrine cells receive intraluminal nutrients as signals and release their hormones into the blood circulation (endocrine) or extracellular space nearby (paracrine) ( Gribble and Reimann, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Dietary Protein Level Influences on Neurotensin-immunoreactive Cells in the Chicken Ileum

2020

Self Cite

View full text Add to dashboard Cite

Neurotensin is secreted from intestinal N cells in response to the food ingestion.Influences of different dietary protein levels on neurotensin-immunoreactive cells in the chicken ileum were examined by using immunohistochemical and morphometrical techniques. The results showed that dietary protein had an obvious influence on neurotensin-immunoreactive cells in the chicken ileum. Four experimental groups were used, with dietary crude protein (CP) levels of 18% (control), 9%, 4.5% and 0%.Enteroendocrine cells showing neurotensin-immunoreactivity were located in crypts and villous epithelium in all groups. Most of the neurotensin-immunoreactive cells in the villous epithelium showed pyramidal or spindle-like shape with a long cytoplasmic process reaching the intestinal lumen, but cells with round or oval shape were found in the CP4.5% and 0% groups. Frequencies of occurrence of neurotensin-immunoreactive cells in the CP18%, 9%, 4.5% and 0% groups were 42.4 ±3.3, 36.6 ±2.2, 30.8 ±2.6 and 25.4 ±3.8 (cell count per mucosal area: cells/mm 2 , mean ± SD), respectively. There were significant differences in neurotensin-immunoreactive cell frequency between the control and lower CP level, 4.5% and 0%, groups. A significant correlation was found between frequency of occurrence of neurotensin-immunoreactive cells and daily protein intake. These results indicate that ingested protein is likely to be a potential signal for neurotensin production and secretion of N cells in the chicken ileum.

show abstract

Section: Discussionmentioning

confidence: 99%

Dietary Protein Level Influences on Neurotensin-immunoreactive Cells in the Chicken Ileum

2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…I-cells, L-cells) have been described and well characterised along the mammalian gastrointestinal tract (Gunawardene et al, 2011;Latorre et al, 2016). In birds, several types of EECs (homologous to those in mammals) have been identified and several studies describe their distribution and morphology in the gastrointestinal tract of different species [chick, Gallus gallus domesticus (Aksoy and Cinar, 2009;Arcamone et al, 2014;Hiramatsu, 2020;Neglia et al, 2005;Reid and Dunn, 2018;Salvi et al, 1996); ostrich, Struthio camelus (Duritis et al, 2013); rufous-collared sparrow, Zonotrichia capensis subtorquata (Mendes et al, 2009)]. Compared with mammals and birds, the knowledge of EEC types in other vertebrates is scarce.…”

Section: Endocrine Connection From the Gut To The Brainmentioning

confidence: 99%

The gut–brain axis in vertebrates: implications for food intake regulation

Blanco

Calo

Soengas

2021

Journal of Experimental Biology

View full text Add to dashboard Cite

The gut and brain are constantly communicating and influencing each other through neural, endocrine and immune signals in an interaction referred to as the gut–brain axis. Within this communication system, the gastrointestinal tract, including the gut microbiota, sends information on energy status to the brain, which, after integrating these and other inputs, transmits feedback to the gastrointestinal tract. This allows the regulation of food intake and other physiological processes occurring in the gastrointestinal tract, including motility, secretion, digestion and absorption. Although extensive literature is available on the mechanisms governing the communication between the gut and the brain in mammals, studies on this axis in other vertebrates are scarce and often limited to a single species, which may not be representative for obtaining conclusions for an entire group. This Review aims to compile the available information on the gut–brain axis in birds, reptiles, amphibians and fish, with a special focus on its involvement in food intake regulation and, to a lesser extent, in digestive processes. Additionally, we will identify gaps of knowledge that need to be filled in order to better understand the functioning and physiological significance of such an axis in non-mammalian vertebrates.

show abstract

“…GLP-1 and GIP are mammalian incretin hormones, and chronic n-3 fatty acid intake elevates plasma GLP-1 levels and increases insulin response in obese mice (Pavlisova et al, 2020). In chickens, proteins and amino acids such as lysine and methionine are triggers that induce GLP-1 secretion from ileal L cells (Hiramatsu, 2020); however, it has not been confirmed whether GPR120 is co-expressed with GLP-1 in chicken gastrointestinal tissues. Furthermore, it is not clear whether PUFA intake induces GLP-1 secretion from the gastrointestinal tissues of chickens.…”

Section: A D V a N C Ementioning

confidence: 99%

Fatty Acid Taste Receptor GPR120 Activation by Arachidonic Acid, Eicosapentaenoic Acid, and Docosahexaenoic Acid in Chickens

et al. 2021

View full text Add to dashboard Cite

It has been reported that the supplementation of chicken diet with polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), eicosapentaenoic acid (EPA), or docosahexaenoic acid (DHA) affects the qualities of eggs and meat. Previous studies have shown that a functional fatty acid taste receptor, G protein-coupled receptor 120 (GPR120), is broadly expressed in chicken oral and gastrointestinal tissues, and chickens have a gustatory perception of oleic acid, which is a chicken GPR120 agonist. The aim of this study was to elucidate the role of chicken GPR120 in response to PUFAs in chicken diets. Ca 2+ imaging analyses revealed that chicken GPR120 was activated by AA, EPA, and DHA in a concentration-dependent manner. These results suggest that chickens can detect PUFAs via GPR120 in the oral and gastrointestinal tissues, implying that chickens have a gustatory perception of PUFAs.

show abstract

Chicken Intestinal L Cells and Glucagon-like Peptide-1 Secretion

Cited by 17 publications

References 67 publications

Dietary Protein Level Influences on Neurotensin-immunoreactive Cells in the Chicken Ileum

Dietary Protein Level Influences on Neurotensin-immunoreactive Cells in the Chicken Ileum

The gut–brain axis in vertebrates: implications for food intake regulation

Fatty Acid Taste Receptor GPR120 Activation by Arachidonic Acid, Eicosapentaenoic Acid, and Docosahexaenoic Acid in Chickens

Contact Info

Product

Resources

About