Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation, and inflammation in mice with methionine and choline deficiency

Kim, Myungsuk; Yoo, Gyhye; Randy, Ahmad; Nho, Chu Won

doi:10.1002/mnfr.201600632

Cited by 33 publications

(23 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Along with its hypoglycemic effect, there are reports of chicoric acid having other functional properties, such as antioxidation, anti-inflammation, and anti-fatty liver activities (63,84). Chicoric acid has been considered a potent antioxidant agent due to its effect on inhibiting the accumulation of reactive oxygen species and the generation of inflammatory cytokines, such as nitrogen oxide, interleukin 6, and tumor necrosis factorα (51,64).…”

Section: Discussionmentioning

confidence: 99%

“…Chicoric acid has been found to reduce high-fat-diet-induced weight gain in mice (63,64). This was in part via the inhibition of peroxisome proliferator-activated receptorγ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα), two critical transcription factors in adipocyte differentiation and lipid accumulation, while increasing the secretion of adiponectin (64).…”

Section: Chicoric Acid and Lipid Metabolism And Liver Functionmentioning

confidence: 99%

“…This was in part via the inhibition of peroxisome proliferator-activated receptorγ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα), two critical transcription factors in adipocyte differentiation and lipid accumulation, while increasing the secretion of adiponectin (64). Similarly, a few studies suggested that chicoric acid protected the liver from high-fat-or alcohol-induced fat accumulation and hepatic steatosis (63)(64)(65).…”

Section: Chicoric Acid and Lipid Metabolism And Liver Functionmentioning

confidence: 99%

See 2 more Smart Citations

The Bioactive Effects of Chicoric Acid As a Functional Food Ingredient

Peng

Sun

Park

2019

Journal of Medicinal Food

View full text Add to dashboard Cite

Yeonhwa Park, for giving me a great opportunity to pursue my Ph.D. study in her lab and for her continuous guidance, support, and patience during the four years. Without her kind help and encouragement, I cannot make it here. My sincere thanks also go to my thesis committee, Dr. McLandsborough and Dr. Kim, for their great support and guidance during my study here. I would like to give special thanks to Dr. Decker, the department head, and Mr. Peter Salmon, the CFS CPP of IFN Consulting, who generously gave great help, financial support, and gracious encouragement to me.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Chicoric Acid and Lipid Metabolism And Liver Functionmentioning

confidence: 99%

Section: Chicoric Acid and Lipid Metabolism And Liver Functionmentioning

confidence: 99%

See 1 more Smart Citation

The Bioactive Effects of Chicoric Acid As a Functional Food Ingredient

Peng

Sun

Park

2019

Journal of Medicinal Food

View full text Add to dashboard Cite

show abstract

“…Cichoric acid is a hydroxycinnamic acid, an organic compound of the phenylpropanoid class, which occurs in a variety of plant species. The oral administration of chicoric acid (10 and 30 mg/ kg) daily for 4 wk reduces the OS by upregulating antioxidant enzymes and decreases the inflammation by inhibiting pro-inflammatory cytokines and NF-κB activation in mice fed with a methionine-and choline-deficient diet [131]. In addition, chicoric acid reduces the fibrosis, apoptosis, and lipogenesis-related gene expression and increases the AMPK activation.…”

Section: Other Compoundsmentioning

confidence: 99%

Fighting Liver Fibrosis with Naturally Occurring Antioxidants

et al. 2018

View full text Add to dashboard Cite

Liver fibrosis is a wound-healing response characterized by the accumulation of extracellular matrix following various liver injuries, which results in the deformation of the normal liver architecture and the development of liver cirrhosis and even hepatocellular carcinoma. Numerous in vitro and in vivo studies indicated that oxidative stress mediates the initiation and progression of liver fibrosis. Overaccumulation of reactive oxygen species disrupts macromolecules, induces necrosis and apoptosis of hepatocytes, stimulates the production of pro-fibrogenic mediators, and directly activates hepatic stellate cells, thereby resulting in liver damage and initiating liver fibrosis. Ameliorating oxidative stress is a potential therapeutic strategy for the treatment of liver fibrosis. Natural antioxidants have attracted increasing attention in treating liver fibrosis due to their safety and efficacy. In this review, the pathogenesis of liver fibrosis and the role of oxidative stress in liver fibrosis were discussed. Naturally occurring antioxidants that can treat and prevent liver fibrosis were summarized. Advances in clinical trials were also presented. The main purpose of this review is to provide a comprehensive and up-to-date knowledge from the biological importance of oxidative stress in liver fibrosis to representative antioxidants for treating liver fibrosis. Naturally occurring antioxidants show a potential for further investigations as lead compounds in fighting liver fibrosis.

show abstract

“…It contains a large amount of bioactive compounds including various hydroxycinnamic acids (HCAs) such as chlorogenic acid, 3,5-di-O-caffeoylquinic acid (3,, chicoric acid and caftaric acid. Several previous studies have reported that C. denticulatum extracts have high anti-oxidative, anti-fatty liver and anti-obesity properties [5][6][7][8], and health functional foods for improving liver function have also been produced using the extract of C. denticulatum. One of the ecological characteristics of C. denticulatum is its sensitivity to the water condition around the root zone with soft rot diseases in the leaf often occurring under conditions of excessive water with frequent rainfall during summer.…”

Section: Introductionmentioning

confidence: 99%

Determination of Adequate Substrate Water Content for Mass Production of a High Value-Added Medicinal Plant, Crepidiastrum denticulatum (Houtt.) Pak & Kawano

Park

Kim

2020

Agronomy

View full text Add to dashboard Cite

The effects of substrate water content on the growth and content of bioactive compounds in Crepidiastrum denticulatum were evaluated. Three-week-old seedlings were subjected to four levels of substrate water content (20%, 30%, 45% and 60%) and maintained for 5 weeks. Growth parameters at 5 weeks of transplanting were significantly higher with the 45% substrate water content treatment than with the other treatments. In addition, photosynthetic rate, stomatal conductance and transpiration rate increased significantly and the highest sap flow rate during the day was observed in 45% substrate water content. Total phenolic content and antioxidant capacity per shoot increased significantly with substrate water content, increasing from 20% to 45% and decreased again at 60%. Antioxidant capacity and total hydroxycinnamic acids (HCAs) content per unit dry weight of plants under the 60% treatment were significantly higher than those under the 45% treatment; however, their content per shoot was the highest under the 45% treatment. Thus, 45% substrate water content is a suitable condition for the growth of C. denticulatum and had positive effects on phenolic content, antioxidant capacity, and HCAs content. These results could be useful for the mass production of high-quality C. denticulatum in greenhouses or plant factories capable of controlling the water content of the root zone.

show abstract

Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation, and inflammation in mice with methionine and choline deficiency

Abstract: CDE and chicoric acid may be effective in the treatment of NAFLD and NASH.

Cited by 33 publications

References 65 publications

The Bioactive Effects of Chicoric Acid As a Functional Food Ingredient

The Bioactive Effects of Chicoric Acid As a Functional Food Ingredient

Fighting Liver Fibrosis with Naturally Occurring Antioxidants

Determination of Adequate Substrate Water Content for Mass Production of a High Value-Added Medicinal Plant, Crepidiastrum denticulatum (Houtt.) Pak & Kawano

Contact Info

Product

Resources

About