Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model

Qu, Yuhan; Shen, Yue; Teng, Li; Huang, Yuehui; Yang, Yuting; Xi, Jun; Wu, Ping; Fu, Qiang

doi:10.1016/j.intimp.2022.109129

Cited by 21 publications

(12 citation statements)

References 48 publications

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“…Nrf2 is the core regulator of the oxidative stress response. Studies have been reported that CA reduces cell inflammation and apoptosis by inhibiting the activation of PI3K/AKT and NF-κB signaling pathways and increasing the expression of Nrf-2/HO-1 . Therefore, PI3K/AKT, NF-κB, and Nrf2 pathways may be important targets for CA to alleviate colitis.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have been reported that CA reduces cell inflammation and apoptosis by inhibiting the activation of PI3K/AKT and NF-κB signaling pathways and increasing the expression of Nrf-2/HO-1. 49 Therefore, PI3K/AKT, NF-κB, and Nrf2 pathways may be important targets for CA to alleviate colitis. In addition, a recent study showed that CA reverses the levels of interleukin-17 (IL-17) and transforming growth factor-β (TGF-β) in mice.…”

Section: Discussionmentioning

confidence: 99%

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Chicoric Acid Alleviates Colitis via Targeting the Gut Microbiota Accompanied by Maintaining Intestinal Barrier Integrity and Inhibiting Inflammatory Responses

Di,

Song,

et al. 2024

J. Agric. Food Chem.

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Polyphenols have shown great potential to prevent ulcerative colitis. As a natural plant polyphenol, chicoric acid (CA) has antioxidant and anti-inflammatory properties. This study explored the intervention effects and potential mechanism of CA on dextran sodium sulfate (DSS)-induced colitis mice. The results showed that CA alleviated the symptoms of colitis and maintained the intestinal barrier integrity. CA significantly downregulated the mRNA expression levels of inflammatory factors including IL-6, IL-1β, TNF-α, IFN-γ, COX-2, and iNOS. In addition, CA modulated the gut microbiota by improving the microbial diversity, reducing the abundance of Gammaproteobacteriaand Clostridium_XI and increasing the abundance ofBarnesiellaandLachnospiraceae. Further fecal microbiota transplantation experiments showed that FM from CA donor mice significantly alleviated the symptoms of colitis, verifying the key role of gut microbiota. These results indicate that CA effectively relieves DSS-induced colitis via targeting gut microbiota along with preserving intestinal barrier function and suppressing inflammatory responses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chicoric Acid Alleviates Colitis via Targeting the Gut Microbiota Accompanied by Maintaining Intestinal Barrier Integrity and Inhibiting Inflammatory Responses

Di,

Song,

et al. 2024

J. Agric. Food Chem.

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“…Chicoric acid is a derivative of caffeic acid. 148 Chicoric acid (30 or 60 mg/kg) pretreatment was found to significantly prevent motor dysfunction and nigrostriatal dopaminergic neuron death in PD mice. 149 Short-chain fatty acids stimulate the proliferation of intestinal epithelial cells and play an important role in improving the integrity of the intestinal barrier.…”

Section: Autophagy Regulation By Hydroxycinnamic Acid Derivativesmentioning

confidence: 93%

“…Chicoric acid is a derivative of caffeic acid . Chicoric acid (30 or 60 mg/kg) pretreatment was found to significantly prevent motor dysfunction and nigrostriatal dopaminergic neuron death in PD mice .…”

Section: Pharmacological Effects Of Hydroxycinnamic Acid Derivatives:...mentioning

confidence: 99%

The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

Yang

Nao

Dong

2023

J. Agric. Food Chem.

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Hydroxycinnamic acid derivatives (HCDs) are polyphenols that are abundant in cereals, coffee, tea, wine, fruits, vegetables, and other plant-based foods. To aid in the clinical prevention and treatment of Parkinson’s disease (PD), we evaluated in vivo investigations of the pharmacological properties of HCDs relevant to PD, and their pharmacokinetic and safety aspects. An extensive search of published journals was conducted using several literature databases, including PubMed, Google Scholar, and the Web of Science. The search terms included “hydroxycinnamic acid derivatives,” “ferulic acid,” “caffeic acid,” “sinapic acid,” “p-coumaric acid,” “Parkinson’s disease,” and combinations of these keywords. As of April 2023, 455 preclinical studies were retrieved, of which 364 were in vivo studies; we included 17 of these articles on the pharmaceutics of HCDs in PD. Available evidence supports the protective effects of HCDs in PD due to their anti-inflammatory, antioxidant, as well as antiapoptotic physiological activities. Studies have identified possible molecular targets and pathways for the protective actions of HCDs in PD. However, the paucity of studies on these compounds in PD, and the risk of toxicity induced with high-dose applications, limits their use. Thus, multifaceted studies of HCDs in vitro and in vivo are needed.

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“…Moreover, it ameliorates indomethacin-induced gastric ulcer in rats [ 102 , 103 ]. DCTA enhances glucose uptake, diminishes insulin resistance and oxidative stress, demonstrates anti-inflammatory and antiviral activity, improves brain and liver functions, and may have beneficial effects in atherosclerosis and osteoarthritis [ 104 , 105 , 106 , 107 ]. In addition to ameliorating cognitive impairment via the promotion of the antioxidant defense system and preventing memory impairment and amyloidogenesis caused by systemic inflammation [ 108 , 109 ], DCTA improves neuron survival against inflammation [ 110 ].…”

Section: Phenolic and Polyphenolic Antioxidants In Hrsmentioning

confidence: 99%

Hairy Root Cultures as a Source of Phenolic Antioxidants: Simple Phenolics, Phenolic Acids, Phenylethanoids, and Hydroxycinnamates

Malarz

Yudina

Stojakowska

2023

IJMS

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Plant-derived antioxidants are intrinsic components of human diet and factors implicated in tolerance mechanisms against environmental stresses in both plants and humans. They are being used as food preservatives and additives or ingredients of cosmetics. For nearly forty years, Rhizobium rhizogenes-transformed roots (hairy roots) have been studied in respect to their usability as producers of plant specialized metabolites of different, primarily medical applications. Moreover, the hairy root cultures have proven their value as a tool in crop plant improvement and in plant secondary metabolism investigations. Though cultivated plants remain a major source of plant polyphenolics of economic importance, the decline in biodiversity caused by climate changes and overexploitation of natural resources may increase the interest in hairy roots as a productive and renewable source of biologically active compounds. The present review examines hairy roots as efficient producers of simple phenolics, phenylethanoids, and hydroxycinnamates of plant origin and summarizes efforts to maximize the product yield. Attempts to use Rhizobium rhizogenes-mediated genetic transformation for inducing enhanced production of the plant phenolics/polyphenolics in crop plants are also mentioned.

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Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model

Cited by 21 publications

References 48 publications

Chicoric Acid Alleviates Colitis via Targeting the Gut Microbiota Accompanied by Maintaining Intestinal Barrier Integrity and Inhibiting Inflammatory Responses

Chicoric Acid Alleviates Colitis via Targeting the Gut Microbiota Accompanied by Maintaining Intestinal Barrier Integrity and Inhibiting Inflammatory Responses

The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

Hairy Root Cultures as a Source of Phenolic Antioxidants: Simple Phenolics, Phenolic Acids, Phenylethanoids, and Hydroxycinnamates

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