Chicoric acid supplementation ameliorates cognitive impairment induced by oxidative stress via promotion of antioxidant defense system

Abstract

Illustration of effects of chicoric acid on neuroprotection againstd-gal-induced memory impairmentviainflammation and oxidative stress.

High Value-Added Biomolecules from Beach Waste of Marine Origin-Screening for Potential Candidates among Seagrass of the Cymodoceaceae Family

“…Considering the demonstrated therapeutic applications of L-chiro-inositol [3,4,48], and chicoric acid [12,13], their high value on the nutraceutical market, and their rare occurrence in the plant kingdom, their presence in Syringodium, Cymodocea and Halodule detrital leaves makes this abundant biomass of interest for dietary and pharmaceutical applications. These results show that there is a real potential for harvesting beachcast Cymodoceacea.…”

“…(1)) is a rare and valuable natural product of special interest owing to its large spectrum of biological properties including antioxidant activities, anti-obesity effects, anti-HIV, and others [11]. These properties explain its success on the nutraceutical market [12,13]. CA is the main phenolic compound in Echinacea purpurea, but it does not occur in appreciable amounts in other species such as E. pallida and E. angustifolia [14].…”

The Bioactive Effects of Chicoric Acid As a Functional Food Ingredient

“…Oxidative stress is defined as the imbalance between the generation of reactive (15,21,25,43,49,61,62,71,76,77). The underlying mechanism of the antioxidative effects of chicoric acid is attributed to the enhanced nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf-2) and the level of peroxisome proliferator-activated receptor-γ coactivator α (PGC-1α) (34,73,75). The activation of Nrf-2 and PGC-1α inhibit ROS-induced cytotoxicity by upregulation of antioxidant response-related genes and promotion of the mitochondrial antioxidant defense system, respectively (78,79).…”

“…Alternatively, NF-κB can be activated in combination with TNF-α (37). Several studies reported that chicoric acid decreased TNF-α production (40,47,64,65,75), which might be a contributing factor to the reduced activation of NF-κB. Chicoric acidrelated deregulations of NF-κB and TNF-α were shown to alleviate conditions such as autoimmune disorders, restraint stress, hepatic steatosis and neuron damage known to be involved in cellular inflammation and associated diseases (34-36, 40, 47, 63-65, 75).…”

Potentiometric and UV-Vis spectrophotometric titrations for evaluation of the antioxidant capacity of chicoric acid

“…15,16 Chicoric acid (ChA) is the main anti-oxidation component of Echinacea. ChA is a water-soluble phenolic acid with anti-inammation, antiviral and anti-oxidation activities, 17,18 and its chemical structure is shown in Scheme S1. † The reported methods for determining the AOC of ChA include UV-Vis spectrophotometry and square wave voltammetry.…”