Chikungunya in Europe

Depoortere, Evelyn; Salmaso, Stefania; Mg, Pompa; Guglielmetti, P; Coulombier, D

doi:10.1016/s0140-6736(08)60336-0

Cited by 21 publications

(7 citation statements)

References 1 publication

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“…These diseases-e.g. dengue, yellow fever and chikungunya-present serious public health concerns, particularly in the light of recent spread events, in which each of the diseases has emerged either in new regions [6] or in new environments [7,8]. As a consequence, Aedestransmitted viral diseases have been of considerable concern in recent years across much of the tropics and subtropics worldwide.…”

Section: Introductionmentioning

confidence: 99%

Climate change influences on global distributions of dengue and chikungunya virus vectors

Campbell

Luther

Moo‐Llanes

et al. 2015

Phil. Trans. R. Soc. B

361

251

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Numerous recent studies have illuminated global distributions of human cases of dengue and other mosquito-transmitted diseases, yet the potential distributions of key vector species have not been incorporated integrally into those mapping efforts. Projections onto future conditions to illuminate potential distributional shifts in coming decades are similarly lacking, at least outside Europe. This study examined the global potential distributions of Aedes aegypti and Aedes albopictus in relation to climatic variation worldwide to develop ecological niche models that, in turn, allowed anticipation of possible changes in distributional patterns into the future. Results indicated complex global rearrangements of potential distributional areas, which—given the impressive dispersal abilities of these two species—are likely to translate into actual distributional shifts. This exercise also signalled a crucial priority: digitization and sharing of existing distributional data so that models of this sort can be developed more rigorously, as present availability of such data is fragmentary and woefully incomplete.

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Section: Introductionmentioning

confidence: 99%

Climate change influences on global distributions of dengue and chikungunya virus vectors

Campbell

Luther

Moo‐Llanes

et al. 2015

Phil. Trans. R. Soc. B

361

251

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“…Chikungunya virus (CHIKV) is a mosquito-transmitted RNA virus that reemerged in the last decade to cause outbreaks of rheumatologic disease on an unprecedented scale (1)(2)(3)(4)(5), including outbreaks in the Americas that affected millions (6). CHIKV infection generally presents with symptoms such as fever, severe joint pain, muscle aches, and rash, which subside in 7-10 days.…”

Section: Introductionmentioning

confidence: 99%

Chikungunya virus impairs draining lymph node function by inhibiting HEV-mediated lymphocyte recruitment

McCarthy¹,

Davenport²,

Reynoso³

et al. 2018

JCI Insight

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Chikungunya virus (CHIKV) causes acute and chronic rheumatologic disease. Pathogenic CHIKV strains persist in joints of immunocompetent mice, while the attenuated CHIKV strain 181/25 is cleared by adaptive immunity. We analyzed the draining lymph node (dLN) to define events in lymphoid tissue that may contribute to CHIKV persistence or clearance. Acute 181/25 infection resulted in dLN enlargement and germinal center (GC) formation, while the dLN of mice infected with pathogenic CHIKV became highly disorganized and depleted of lymphocytes. Using CHIKV strains encoding ovalbumin-specific TCR epitopes, we found that lymphocyte depletion was not due to impaired lymphocyte proliferation. Instead, the accumulation of naive lymphocytes transferred from the vasculature to the dLN was reduced, which was associated with fewer high endothelial venule cells and decreased CCL21 production. Following NP-OVA immunization, NP-specific GC B cells in the dLN were decreased during pathogenic, but not attenuated, CHIKV infection. Our data suggest that pathogenic, persistent strains of CHIKV disable the development of adaptive immune responses within the dLN.

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“…L'expertise intègre de plus en plus souvent les modèles mathématiques qui permettent par exemple d'estimer le risque d'importation du Sras ou de la dengue en Europe [12,13] ou d'évaluer l'impact des mesures de contrôle aux frontières pour la réduction de la diffusion d'une pandémie grippale [14][15][16]. L'analyse de risque peut être effectuée conjointement par plusieurs pays frontaliers ou sous la coordination et l'impulsion des institutions internationales : le risque d'implantation du Chikungunya en France métropolitaine et sur le pourtour méditerranéen a fait l'objet de diverses expertises nationales et européennes [17][18][19][20].…”

Section: Expertise Et Analyse Du Risqueunclassified

Veille sanitaire et appréciation du risque infectieux émergent : méthode et critères d’analyse du risque

Bitar

Che

Capek

et al. 2011

Médecine et Maladies Infectieuses

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Chikungunya in Europe

Cited by 21 publications

References 1 publication

Climate change influences on global distributions of dengue and chikungunya virus vectors

Climate change influences on global distributions of dengue and chikungunya virus vectors

Chikungunya virus impairs draining lymph node function by inhibiting HEV-mediated lymphocyte recruitment

Veille sanitaire et appréciation du risque infectieux émergent : méthode et critères d’analyse du risque

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