Chikungunya: Molecular Aspects, Clinical Outcomes and Pathogenesis

Bautista-Reyes, Eduardo; Núñez-Avellaneda, Daniel; Alonso-Palomares, Luis; Salazar, Ma Isabel

doi:10.24875/ric.17002029

Cited by 11 publications

(11 citation statements)

References 62 publications

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“…The emergence of CHIKV and ZIKV in a region endemic for dengue creates new challenges for public health authorities, since the initial clinical profi les of these arboviruses are very similar 1,12,23 , and laboratory tests are not always available for rapid confi rmation, which makes accurate diagnosis diffi cult. Some authors emphasize the importance of detailed clinical analyses on the fi rst three days of acute symptoms, which should be followed by laboratory diagnosis and follow-up of the patients' progression 24,25 .…”

Section: Discussionmentioning

confidence: 99%

Emergence of chikungunya and Zika in a municipality endemic to dengue, Santa Luzia, MG, Brazil, 2015-2017

Vega

Bezerra

Said

et al. 2019

Rev. Soc. Bras. Med. Trop.

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Introduction: The recent circulation of arboviruses transmitted by vectors, such as dengue, chikungunya, and Zika, is concerning due to the high morbidity rates, clinical complications, and increased demand on health services. The objective of this study was to analyze the clinical and epidemiological aspects of an epidemic caused by arboviruses in the municipality of Santa Luzia, Minas Gerais, Brazil. Methods: Longitudinal study of patients with acute febrile disease and suspected arbovirus infection reported to Brazilian Notifiable Disease Information System (Sistema de Informação de Agravos de Notificação) from the epidemiological week 44 of 2015 to epidemiological week 52 of 2016. Patients with confirmed chikungunya were followed-up for 18 months and those with Zika for 15 months. Additionally, we analyzed and described the temporal distribution of confirmed cases of these arboviruses in this municipality. Results: Overall 3,531 arboviruses cases, including 3,481 (98.7%) cases of dengue, 38 (1.0%) cases of chikungunya, and 12 (0.3%) cases of Zika were confirmed. The highest incidence of arbovirus infection occurred in the first quarter of 2016 (epidemiological week 7 to 14). The most frequent symptoms were for dengue, which included fever, headache, retro-orbital pain, and exanthema. Chikungunya infection was associated with fever, myalgia, arthralgia, and rash while Zika infection with pruritus and rash. Conclusions: Given the similarities in the initial clinical profiles of these arboviruses, it is important to perform a detailed clinical analysis, laboratory diagnosis, and patient follow-up.

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Section: Discussionmentioning

confidence: 99%

Emergence of chikungunya and Zika in a municipality endemic to dengue, Santa Luzia, MG, Brazil, 2015-2017

Vega

Bezerra

Said

et al. 2019

Rev. Soc. Bras. Med. Trop.

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“…Most parenchymal cells express interleukin-17 receptors. Signaling through these receptors induces target cells to produce proinflammatory factors, such as IL-1, IL-6, IL-8, TNF, and matrix metalloproteinases capable of destroying the extracellular matrix and causing bone resorption [2,62,70]. This helps in understanding cases of bone erosion and joint damage in patients with CCA (Figure 2).…”

Section: Pathogenesis Of Chronic Chikungunya Arthritismentioning

confidence: 99%

“…As CCA is similar to RA [26,30,36] and has a similar pathogenesis [2,62,63,64], the improvement of patients with CCA using MTX [20,41] could be due to the increase in adenosine, in addition to the decrease in levels of inflammatory interleukins.…”

Section: Methotrexate Therapy Of Chronic Chikungunya Arthritismentioning

confidence: 99%

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The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis

Amaral

Taylor

Teixeira

et al. 2019

Viruses

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Chikungunya fever (CHIKF) is an emerging viral infection that has spread widely, along with its Aedes vectors, throughout the tropics and beyond, causing explosive epidemics of acute illness and persistent disabling arthritis. The rheumatic symptoms associated with chikungunya virus (CHIKV) infection include polyarthralgia, polyarthritis, morning stiffness, joint edema, and erythema. Chronic CHIK arthritis (CCA) often causes severe pain and associated disability. The pathogenesis of CCA is not well understood. Proposed hypotheses include the persistence of a low level of replicating virus in the joints, the persistence of viral RNA in the synovium, and the induction of autoimmunity. In this review, we describe the main hypotheses of CCA pathogenesis, some of which support methotrexate (MTX) treatment which has been shown to be effective in preliminary studies in CCA.

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“…The molecular targets for CHIKV have already been exhaustively reviewed (Bautista-Reyes et al, 2017; da Silva-Júnior et al, 2017). nSP1, nSP2, and nSP3 are important potent inhibitors of the virus, as well as inhibitors to the known E1-E2.…”

Section: Chikungunya Virus Infection In Vertebrate Hostsmentioning

confidence: 99%

Aedes–Chikungunya Virus Interaction: Key Role of Vector Midguts Microbiota and Its Saliva in the Host Infection

et al. 2019

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Aedes mosquitoes are important vectors for emerging diseases caused by arboviruses, such as chikungunya (CHIKV). These viruses’ main transmitting species are Aedes aegypti and Ae. albopictus , which are present in tropical and temperate climatic areas all over the globe. Knowledge of vector characteristics is fundamentally important to the understanding of virus transmission. Only female mosquitoes are able to transmit CHIKV to the vertebrate host since they are hematophagous. In addition, mosquito microbiota is fundamentally important to virus infection in the mosquito. Microorganisms are able to modulate viral transmission in the mosquito, such as bacteria of the Wolbachia genus, which are capable of preventing viral infection, or protozoans of the Ascogregarina species, which are capable of facilitating virus transmission between mosquitoes and larvae. The competence of the mosquito is also important in the transmission of the virus to the vertebrate host, since their saliva has several substances with biological effects, such as immunomodulators and anticoagulants, which are able to modulate the host’s response to the virus, interfering in its pathogenicity and virulence. Understanding the Aedes vector-chikungunya interaction is fundamentally important since it can enable the search for new methods of combating the virus’ transmission.

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Chikungunya: Molecular Aspects, Clinical Outcomes and Pathogenesis

Cited by 11 publications

References 62 publications

Emergence of chikungunya and Zika in a municipality endemic to dengue, Santa Luzia, MG, Brazil, 2015-2017

Emergence of chikungunya and Zika in a municipality endemic to dengue, Santa Luzia, MG, Brazil, 2015-2017

The Clinical Features, Pathogenesis and Methotrexate Therapy of Chronic Chikungunya Arthritis

Aedes–Chikungunya Virus Interaction: Key Role of Vector Midguts Microbiota and Its Saliva in the Host Infection

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