Chikungunya Myocarditis: An Emerging Threat to America

Mendoza, Iván; Morr, Igor; Morr, Carlos; Morr, Claudia; Meza, Yolimar; Marques, J.; Villalobos, Iris

doi:10.1016/s0735-1097(15)60946-9

Cited by 11 publications

(13 citation statements)

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“…Again, according to the severity, findings may range from premature auricular and ventricular extrasystoles to atrial fibrillation with high risk of thromboembolism; and in the worst-case scenario, ventricular fibrillation and sudden death 19 . This wide spectrum directly correlates with the symptoms and hemodynamic state of the patient 31 .…”

Section: Resultsmentioning

confidence: 90%

Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review

et al. 2017

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Background: In the last three years, chikungunya virus disease has been spreading, affecting particularly the Americas, producing more than two million cases. In this setting, not only new disease-related epidemiological patterns have been found, but also new clinical findings have been reported by different research groups. These include findings on the cardiovascular system, including clinical, electrocardiographic and echocardiographic alterations. No previous systemic reviews have been found in major databases about it. Methods: We performed a systematic review looking for reports about cardiovascular compromise during chikungunya disease. Cardiac compromise is not so common in isolated episodes; but countries where chikungunya virus is an epidemic should be well informed about this condition. We used 6 bibliographical databases as resources: Medline/Pubmed, Embase, ScienceDirect, ClinicalKey, Ovid and SciELO. Dengue reports on cardiovascular compromise were included as well, to compare both arbovirus' organic compromises. Articles that delved mainly into the rheumatic articular and cutaneous complications were not considered, as they were not in line with the purpose of this study. The type of articles included were reviews, meta-analyses, case-controls, cohort studies, case reports and case series. This systematic review does not reach or performed a meta-analysis. Results: Originally based on 737 articles, our reviewed selected 40 articles with 54.2% at least mentioning CHIKV cardiovascular compromise within the systemic compromise. Cardiovascular manifestations can be considered common and have been reported in France, India, Sri Lanka, Malaysia, Colombia, Venezuela and USA, including mainly, but no limited to: hypotension, shock and circulatory collapse, Raynaud phenomenon, arrhythmias, murmurs, myocarditis, dilated cardiomyopathy, congestive insufficiency, heart failure and altered function profile (Troponins, CPK). Conclusions: Physicians should be encouraged to keep divulgating reports on the cardiovascular involvement of chikungunya virus disease, to raise awareness and ultimately encourage suitable diagnosis and intervention worldwide. More research about cardiovascular involvement and manifestations of systemic Chikungunya virus infection is urgently needed.

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Section: Resultsmentioning

confidence: 90%

Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 90%

Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review

et al. 2017

View full text Add to dashboard Cite

Background: In the last three years, chikungunya virus disease has been spreading, affecting particularly the Americas, producing more than two million cases. In this setting, not only new disease-related epidemiological patterns have been found, but also new clinical findings have been reported by different research groups. These include findings on the cardiovascular system, including clinical, electrocardiographic and echocardiographic alterations. Methods: We performed a systematic review looking for reports about cardiovascular compromise during chikungunya disease. Cardiac compromise is not so common in isolated episodes; but countries where chikungunya virus is an epidemic should be well informed about this condition. We used 6 bibliographical databases as resources: Medline/Pubmed, Embase, ScienceDirect, ClinicalKey, Ovid and SciELO. Dengue reports on cardiovascular affectation were included as well, to compare both arbovirus’ organic affectations. Articles that delved mainly into the rheumatic articular and cutaneous complications were not considered, as they were not in line with the purpose of this study. The type of articles included were reviews, meta-analyses, case-controls, cohort studies, case reports and case series. Results: Originally based on 737 articles, our reviewed selected 40 articles with 54.2% at least mentioning CHIKV cardiovascular compromise within the systemic affectation. Cardiovascular manifestations can be considered common and have been reported in France, India, Sri Lanka, Malaysia, Colombia, Venezuela and USA, including mainly, but no limited to: hypotension, shock and circulatory collapse, Raynaud phenomenon, arrhythmias, murmurs, myocarditis, dilated cardiomyopathy, congestive insufficiency, heart failure and altered function profile (Troponins, CPK). Conclusions: Physicians should be encouraged to keep divulgating reports on the cardiovascular involvement of chikungunya virus disease, to raise awareness and ultimately encourage suitable diagnosis and intervention worldwide.

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“…These deaths include patients at various ages, newborns, children, young and old adults, previously healthy people and patients with comorbidities. The main complications leading to death were myocarditis, septic shock, encephalitis, and respiratory complications [17][18][19][20][21][22][23] The present study suggested a strong temporal correlation between general mortality and the chikungunya epidemic occurring in Jamaica. The age groups with the greatest increase in mortality during the epidemic period were the same identified in Reunion Island as chikungnuya deaths [5] and in Brazil through excess mortality [24].…”

Section: Discussionmentioning

confidence: 89%

“…Since chikungunya began to be transmitted in the Americas, several authors have demonstrated the occurrence of laboratory confirmed cases of death [17][18][19][20][21] (Evans-Gilbert, 2017, Hotz, 2015, Sá, 2017, Rollé, 2016, Mendoza, 2015, 2016). These deaths include patients at various ages, newborns, children, young and old adults, previously healthy people and patients with comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Excess deaths associated with the chikungunya epidemic of 2014 in Jamaica were higher among children under 5 and over 40 years of age, an analysis based on official data

Freitas

Donalísio

2017

Preprint

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Excess deaths associated with the chikungunya epidemic of 2014 in Jamaica were higher among children under 5 and over 40 years of age, an analysis based on official data. Running title:Mortality associated chikungunya Jamaica Title:Excess deaths associated with the chikungunya epidemic of 2014 in Jamaica were higher among children under 5 and over 40 years of age, an analysis based on official data. peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/227579 doi: bioRxiv preprint first posted online Dec. 8, 2017; Abstract:We assessed the excess of all causes of mortality by age groups during the chikungunya epidemics in Jamaica, 2014. Excess mortality was estimated by subtracting deaths observed in 2014 from that expected based on the average mortality rate of 2012-2013, with confidence interval of 99%.Overall mortality 91.9 / 100,000 population, 2,499 additional deaths than expected coincided with the peak of the epidemic, there was a strong correlation between the monthly incidence and the excess of deaths (Spearman Rho = 0.939; p <0.005). No other significant epidemiological phenomenon occurred on that island that could explain this increase in mortality. Thus, we suggest that mortality associated with chikungunya is underestimated in Jamaica, as in other countries.The excess of deaths could be a strategic tool for the epidemiological surveillance of chikungunya as it has already been used in influenza and respiratory syncytial.

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Chikungunya Myocarditis: An Emerging Threat to America

Cited by 11 publications

References 0 publications

Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review

Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review

Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: A systematic review

Excess deaths associated with the chikungunya epidemic of 2014 in Jamaica were higher among children under 5 and over 40 years of age, an analysis based on official data

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