Chikungunya on Kidney Transplant Recipients: Is It the Same?

Tavares, Bruno de Melo; Fernandes, Paulo Roberto Nunes; Oliveira, Cláudia Maria Costa de; Silva, Sônia L.; Mota, Márcia Uchoa; Andrade, Tacilla Hs; Cunha, Samuel Frota; Girão, Evelyne Santana

doi:10.1097/tp.0000000000002363

Cited by 12 publications

(17 citation statements)

References 16 publications

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“…Clinical manifestations in transplant recipients have been previously described in other arboviruses. In renal transplant recipients, dengue manifestations appear to be similar to the general population, with some degree of graft dysfunction [43], with similar findings with Chikungunya infection [44]. Dengue virus shedding has been demonstrated to be more prolonged in immunocompromised persons (up to 80 days) compared to immunocompetent patients (up to 7 days) [45].…”

Section: Prevention In Transplant Candidatesmentioning

confidence: 63%

Yellow Fever: Prevention in Transplant Candidates and Emerging Treatment Data for Liver Transplant

Song¹,

D’Albuquerque²

2020

Emerging Transplant Infections

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Despite the availability of an efficacious vaccine, yellow fever continues to pose an emerging human health issue, with outbreaks in Africa and South America. Although the majority of cases are oligosymptomatic, severe cases present high mortality, reaching an overall lethality of 50%. The mainstay for yellow fever control remains adequate vaccine coverage. Because the yellow fever vaccine is composed of live, attenuated virus, it is contraindicated in solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients; the vaccine should be preferably administered prior to transplantation. However, transplantation candidates should be evaluated regarding the safety and efficacy of vaccination. In this chapter, we review the current literature

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Section: Prevention In Transplant Candidatesmentioning

confidence: 63%

Yellow Fever: Prevention in Transplant Candidates and Emerging Treatment Data for Liver Transplant

Song¹,

D’Albuquerque²

2020

Emerging Transplant Infections

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“…CHIKV and other arboviruses such as Dengue, Zika and Yellow fever (YF) can infect people living in or traveling to endemic areas in Latin America, Africa, and East Asia. There are few data about arboviruses in solid organ transplant recipients, but the real incidence of these infectious diseases is probably greater than we think 9,10 . There is no reported case of YF transmitted by blood transfusion or organ transplantation, probably due to the vaccine against YF.…”

Section: Discussionmentioning

confidence: 82%

“…The virus life cycle involves human and other primates that live in the jungle, although urban transmission can occur due to mosquito habits. The vectors Aedes aegypti and Aedes albopictus also transmit Zika virus and Dengue virus, so they have the same endemic areas of transmission, and coinfections have been documented 10,13 . CHIKV may also be transmitted via maternal-fetal blood infection and rarely via solid organ transplantation, only if viremia is above 10 4 -10 9 RNA copies/mL and the recipient has a lack of specific IgM and IgG response 14 .…”

Section: Discussionmentioning

confidence: 99%

Chikungunya in a kidney transplant recipient: a case report

et al. 2019

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Em 2004, um surto global de Chikungunya afetou a maioria das regiões tropicais e subtropicais do mundo. Em 2016, um surto ocorreu no Nordeste do Brasil com centenas de casos documentados. Receptores de transplantes de órgãos sólidos têm uma resposta imune modificada à infecção, e o curso clínico é geralmente diferente daquele em pacientes imunocompetentes. O diagnóstico pode ser desafiador nessa população. A maioria dos relatos descreve pacientes residentes em áreas endêmicas, embora devamos enfatizar a importância do diagnóstico diferencial em viajantes transplantados renais que visitam regiões endêmicas, como o Nordeste do Brasil. Aqui, nós relatamos o caso de um receptor de transplante renal que adquiriu febre Chikungunya após uma viagem a uma região endêmica no Nordeste do Brasil durante o surto de 2016, com uma boa evolução clínica. Também apresentamos recomendações de alerta para viajantes em áreas endêmicas, como medidas adicionais para prevenir surtos de doenças.

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“…CHIKV belongs to the Alphavirus genus, and is transmitted via the bite of the mosquito of the genus Aedes, with Aedes aegypti being the most frequent species in the transmission of the virus [2]. The first case of infection with this virus, described in the literature, occurred in the year 1950, in Tanzania [7], subsequently, in the 1960s and 1970s decades, small outbreaks occurred over the years, as in Asia and Africa respectively [8]. In 2013 year, it appeared in the Americas and in 2014, the first virus infection indigenous case was identified [7].…”

Section: Introductionmentioning

confidence: 99%

“…The first case of infection with this virus, described in the literature, occurred in the year 1950, in Tanzania [7], subsequently, in the 1960s and 1970s decades, small outbreaks occurred over the years, as in Asia and Africa respectively [8]. In 2013 year, it appeared in the Americas and in 2014, the first virus infection indigenous case was identified [7]. In 2016, in Brazil, there were approximately 265,000suspected cases of affected by the infection [9].…”

Section: Introductionmentioning

confidence: 99%

Arbovirus in Transplants of Solid Organs and Eyeball:high Risk in Endemic Area Receptors?/ Arbovírus Em Transplantes De Órgãos Sólidos E Globo Ocular:alto Risco Em Receptores De Área Endêmica?

Carneiro

Silva

2021

BJD

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This work is a retrospective cross-sectional analytical study that evaluated individuals transplanted from solid organs and eye balls that had infection by the Chikungunya or Zika virus and, received the organ from an asymptomatic donor. An epidemiological assessment of infection by the Chikungunya and Zika virus in Brazil, was also carried out, and an assessment of the organ and eyeball transplant situation in Brazil. Other data were obtained from the literature, carrying out a survey of articles published in the PUBMED database, from January 2015 to December 2019, which released data from case reports and retrospective and prospective studies. The symptoms most frequently associated with CHIKV are myalgia (60% -93%), fever above 38.9 ºC (90%) and asymptomatic cases (16% -27%), which are not as frequent, but are relevant when it comes to transplants. Symptoms and signs generally associated with Zika virus infection are skin rashes (91%), fever above 38.9º C (65% -80%), in addition to asymptomatic (80%). We found that recipients of organs contaminated with CHIKV or ZIKV may have different outcomes depending on the transplanted organ. Through this evidence, people who had a recent infection or death from these arboviruses could be candidates for kidney and liver donation.

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Chikungunya on Kidney Transplant Recipients: Is It the Same?

Abstract: The chance of CHIKV infection becoming chronic arthralgia in KTR was not different from data in literature. Seven patients presented AKI in the acute phase of infection, although that did not persist. Previous costicosteroids use did not relate with AKI or chronic arthralgia.

Cited by 12 publications

References 16 publications

Yellow Fever: Prevention in Transplant Candidates and Emerging Treatment Data for Liver Transplant

Yellow Fever: Prevention in Transplant Candidates and Emerging Treatment Data for Liver Transplant

Chikungunya in a kidney transplant recipient: a case report

Arbovirus in Transplants of Solid Organs and Eyeball:high Risk in Endemic Area Receptors?/ Arbovírus Em Transplantes De Órgãos Sólidos E Globo Ocular:alto Risco Em Receptores De Área Endêmica?

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