Chikungunya Virus Infection during Pregnancy, Réunion, France, 2006

Fritel, Xavier; Rollot, Olivier; Gérardin, Patrick; Gaüzère, Bernard-Alex; Bideault, Jacques; Lagarde, Louis; Dhuime, Barbara; Orvain, E; Cuillier, Fabrice; Ramful, Duksha; Sampériz, Sylvain; Jaffar-Bandjee, Marie Christine; Michault, Alain; Cotte, L.; Kaminski, Monique; Fourmaintraux, A

doi:10.3201/eid1603.091403

Cited by 63 publications

(73 citation statements)

References 18 publications

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“…The reported cases are of newborns that begin with symptoms during the first week of life, which is compatible with the incubation period of the virus. It is believed that vertical transmissions occur due to placental microtransfusions during labor in mothers with active viremia 5,8 . The infection is also possible during the passage through the birth canal, but in cesarean delivery patients have not been considered as a protective factor 7 .…”

Section: Discussionmentioning

confidence: 99%

Reporte de caso de transmisión vertical de la infección por virus chikungunya

Cardona-Correa

Castaño-Jaramillo

Quevedo-Vélez

2017

Rev. chil. pediatr.

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Chikungunya virus infection is a disease transmitted by vectors, in which vertical transmission was described in years [2005][2006]. An infection rate up to 49% in neonates born from mothers with active viremia during labor has been observed. Perinatal infection could results in serious complications and potential cognitive impairment. Objective: To describe a newborn with Chikungunya virus infection secundary to vertical transmission. Clínical case: A female newborn is analyzed. She presented with fever and exanthema during her first week of life, elevation of transaminases and thrombocytopenia. Her mother had had symptoms compatible with chikungunya virus infection on the day of the delivery. Specific IgM antibodies against chikungunya were documented and the diagnosis was confirmed. Conclusion: Given the high perinatal transmissibility rate of chikungunya virus, this diagnosis should be considered in every newborn child of a mother with suggestive symptoms of chikungunya in the days surrounding delivery.

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Section: Discussionmentioning

confidence: 99%

Reporte de caso de transmisión vertical de la infección por virus chikungunya

Cardona-Correa

Castaño-Jaramillo

Quevedo-Vélez

2017

Rev. chil. pediatr.

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“…Mother-to-child transmission of CHIKV was reported during the 2005 and 2006 outbreak on Ré union Island 22 ; vertical transmission was observed almost exclusively in the context of intrapartum viremia, and it was associated with a high rate of neonatal morbidity. 23,24 Because pregnancy-associated malaria is an important cause of maternal and fetal morbidity and mortality, 25 in a malaria high-risk area such as Cotonou, acute CHIKV infection of a malaria-infected woman close to delivery could worsen pregnancy outcome.…”

mentioning

confidence: 99%

High Seroprevalence of Chikungunya Virus Antibodies Among Pregnant Women Living in an Urban Area in Benin, West Africa

Bacci¹,

Marchi²,

Fiévet³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. The aim of this study was to investigate the seroprevalence of antichikungunya virus (anti-CHIKV) antibodies in pregnant women living in an urban area of Benin (West Africa). Results were obtained by screening sera collected in 2006 and 2007 with enzyme-linked immunosorbent assay (ELISA) for anti-CHIKV immunoglobulin G (IgG) and IgM. Positive results were confirmed by indirect immunofluorescence test and microneutralization assay. We found that a large proportion (36.1%) of pregnant women living in Cotonou had specific IgG against CHIKV, indicating a high seroprevalence of the infection in urban southern Benin, whereas no active cases of CHIKV infection were detected.Arboviruses that are transmitted by Aedes mosquitoes, such as dengue virus and chikungunya virus (CHIKV) infections, are a global threat because of their rapid and abrupt spread worldwide and the infection-related disease burden.

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“…Moreover, numerous cases of active and destructive CHIKVassociated rheumatoid arthritis have been reported (17)(18)(19). The vertical transmission of the virus has also been extensively investigated these last few years (20)(21)(22). Although CHIKV motherto-fetus transmission appears to be extremely rare when the infection occurs early during pregnancy, up to 50% of the neonates experience development of CHIKV-associated clinical symptoms when mothers are infected shortly before delivery.…”

mentioning

confidence: 99%

Chikungunya Virus Envelope-Specific Human Monoclonal Antibodies with Broad Neutralization Potency

Warter

Lee

Thiagarajan

et al. 2011

The Journal of Immunology

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Chikungunya virus (CHIKV) is an alphavirus responsible for numerous epidemics in Africa and Asia. Infection by CHIKV is often characterized by long-lasting, incapacitating arthritis, and some fatal cases have been described among elderly and newborns. Currently, there is no available vaccine or specific treatment against CHIKV. Blood B cells from a donor with history of CHIKV infection were activated, immortalized, amplified, and cloned. Two human mAbs against CHIKV, 5F10 and 8B10, were identified, sequenced, and expressed in recombinant form for characterization. In a plaque reduction neutralization test, 5F10 and 8B10 show mean IC50 of 72 and 46 ng/ml, respectively. Moreover, both mAbs lead to a strong decrease in extracellular spreading of infectious viral particles from infected to uninfected cells. Importantly, the mAbs neutralize different CHIKV isolates from Singapore, Africa, and Indonesia, as well as O’nyong-nyong virus, but do not recognize other alphaviruses tested. Both mAbs are specific for the CHIKV envelope: 5F10 binds to the E2 glycoprotein ectodomain and 8B10 to E1 and/or E2. In conclusion, these two unique human mAbs strongly, broadly, and specifically neutralize CHIKV infection in vitro and might become possible therapeutic tools against CHIKV infection, especially in individuals at risk for severe disease. Importantly, these mAbs will also represent precious tools for future studies on host–pathogen interactions and the rational design of vaccines against CHIKV.

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Chikungunya Virus Infection during Pregnancy, Réunion, France, 2006

Cited by 63 publications

References 18 publications

Reporte de caso de transmisión vertical de la infección por virus chikungunya

Reporte de caso de transmisión vertical de la infección por virus chikungunya

High Seroprevalence of Chikungunya Virus Antibodies Among Pregnant Women Living in an Urban Area in Benin, West Africa

Chikungunya Virus Envelope-Specific Human Monoclonal Antibodies with Broad Neutralization Potency

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