Chilblains and antiphospholipid antibodies: report of four cases and review of the literature

Lutz, V.; Cribier, B.; Lipsker, Dan

doi:10.1111/j.1365-2133.2010.09829.x

Cited by 17 publications

(10 citation statements)

References 8 publications

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“…9,[12][13][14] Chilblains may Goutières syndrome, and IRAK4 deficiency); and (f) anorexia and diseases causing weight reduction. 10,15,16 None of these possible etiologies were present in our patients, not even cold exposure, and given the timing, SARS-CoV-2 is felt to be the most likely etiology of chilblains in these patients. Five of our patients were receiving medications for ADHD, and these have been linked to blue toe syndrome and cyanotic peripheral vasculopathy.…”

Section: Re Sultsmentioning

confidence: 65%

Chilblains in children in the setting of COVID‐19 pandemic

Andina

Noguera‐Morel

Bascuas-Arribas

et al. 2020

Pediatric Dermatology

191

328

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BackgroundDifferent skin manifestations of COVID‐19 are being reported. Acral lesions on the hands and feet, closely resembling chilblains, have been recognized during the peak incidence of the COVID‐19 pandemic.Material and methodsA retrospective review of 22 children and adolescents with chilblain‐like lesions seen over a short period of time in the Emergency Department of a children's hospital during the peak incidence of COVID‐19 in Madrid, Spain.ResultsAll patients had lesions clinically consistent with chilblains of the toes or feet, with three also having lesions of the fingers. Pruritus and mild pain were the only skin symptoms elicited, and only 10 had mild respiratory and/or GI symptoms. None had fever. Coagulation tests, hemogram, serum chemistry, and lupus anticoagulant were normal in all patients tested. One out of 16 tested cases had elevated D‐dimer results, but without systemic symptoms or other laboratory anomalies. SARS‐CoV‐2 PCR tested in 19 cases was positive in just one case. Skin biopsies obtained in six patients were consistent with chilblains. On follow‐up, all cases showed spontaneous marked improvement or complete healing.ConclusionAcute chilblains were observed during COVID‐19 pandemic in children and teenagers. It is a mildly symptomatic condition with an excellent prognosis, usually requiring no therapy. Etiopathogenesis remains unknown.

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Section: Re Sultsmentioning

confidence: 65%

Chilblains in children in the setting of COVID‐19 pandemic

Andina

Noguera‐Morel

Bascuas-Arribas

et al. 2020

Pediatric Dermatology

191

328

View full text Add to dashboard Cite

show abstract

“…Indeed, this process may not represent a forme fruste but rather may actually represent cutaneous LE involving acral skin without any associated systemic disease, akin to tumid and discoid LE, in which most of these cases have no association with systemic disease. In addition, chilblain and a chilblain‐like eruption have been reported in patients with antiphopholipid antibodies, Behcet's disease, and hematologic malignancy, mainly leukemia . In 13 reported patients with chilblain and antiphospholipid antibodies, 2 developed systemic LE and 9 had primary antiphopholipid syndrome …”

Section: Discussionmentioning

confidence: 99%

“…In addition, chilblain and a chilblain‐like eruption have been reported in patients with antiphopholipid antibodies, Behcet's disease, and hematologic malignancy, mainly leukemia . In 13 reported patients with chilblain and antiphospholipid antibodies, 2 developed systemic LE and 9 had primary antiphopholipid syndrome …”

Section: Discussionmentioning

confidence: 99%

Equestrian chilblain: another outdoor recreational hazard

Yang

Schwartz²,

Divers³

et al. 2013

J Cutan Pathol

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Herein, we describe two cases and review 14 cases of equestrian chilblain or 'equestrian cold panniculitis' in the literature. The first, a 23-year-old healthy female horse trainer, presented with burning nodular swelling on her lateral thighs. The second was a 34-year-old healthy woman with recurrent nodular eruption on the lateral thighs after horseback riding in the winter. Physical examination of both patients revealed erythematous to violaceous nodules with eczema craquelé-like changes. Laboratory workup for systemic and autoimmune connective tissue disease was negative. Punch biopsies from both patients showed a superficial and deep perivascular and periadnexal lymphocytic infiltrate with focal extension into the subcutaneous fat. Parakeratosis, subtle spongiosis and increased pandermal interstitial mucin were also present. Previously reported cases generally showed a similar clinical course and similar histopathologic findings. In contrast, our cases revealed increased pandermal interstitial mucin, resembling tumid lupus erythematosus. We aim to better characterize the histopathologic findings of equestrian chilblain and discuss its relationship to other cold-induced skin injuries and autoimmune connective tissue disease, namely lupus erythematosus.

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“…2,3 Chilblains can can present as a secondary feature of diseases such as systemic lupus erythematosus, Behçet disease, chronic myelomonocytic leukemia, metastatic breast carcinoma, cryoglobulinemia, cryofibrinogenemia, cold agglutinin disease, macroglobulinemia, Aicardi-Goutieres syndrome and anorexia nervosa. 4,5 Laboratory investigations and cutaneous biopsy may be performed when lesions are persistent or when there is suspicion of underlying systemic disease.…”

Section: Introductionmentioning

confidence: 99%

Chilblains in Turkey: a case-control study

Akkurt

Uçmak

Yildiz

et al. 2014

An. Bras. Dermatol.

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BACKGROUNDChilblains are rather common in winter months in our country. OBJECTIVESDetermination of demographical and clinical characteristics of patients presenting with chilblains in Diyarbakir, Turkey. Evaluation of body mass index (BMI) as risk factor for development of chilblains. METHODSSixty-nine patients who were diagnosed as chilblains at our outpatient clinics were included in this study. No exclusion criteria were sought. Demographical data including height and weight and answers to questions related to personal history were recorded. A control group consisting of 108 controls were chosen from among patients presenting with complaints of hair loss. Statistical analyses were conducted using SPSS 17.0. RESULTSOf the 69 patients with chilblains, 45 (65.2%) were females and 24 (34.8%) were males. Mean age (±SD) of the patients was 21±9. 71.2% of the patients complained of itching, 51.6% of pain, 31.3% of burning in the lesions. 61.3% of the patients reported recurrence of the lesions every winter season. Mean BMI of the patients was 20.5±2.9. Mean BMI of the controls was 22.4±3.7 and the difference was statistically significant (p=0.01). CONCLUSIONSLow BMI may be a risk factor contributing to development of chilblains in persons exposed to cold weather conditions. Apart from external factors, there seems to be a personal tendency to develop lesions, as many patients report recurrences every year. Diagnosis of chilblains requires wariness, as history of cold exposure may not be evident.

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Chilblains and antiphospholipid antibodies: report of four cases and review of the literature

Cited by 17 publications

References 8 publications

Chilblains in children in the setting of COVID‐19 pandemic

Chilblains in children in the setting of COVID‐19 pandemic

Equestrian chilblain: another outdoor recreational hazard

Chilblains in Turkey: a case-control study

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