Child–Adult Transition in Sarcoidosis: A Series of 52 Patients

Abstract

<jats:p>(1) Background: Pediatric sarcoidosis is a rare and mostly severe disease. Very few pediatric series with a prolonged follow-up are reported. We aimed to evaluate the evolution of pediatric sarcoidosis in adulthood. (2) Material and methods: Patients over 18-years-old with a pediatric-onset sarcoidosis (≤15-year-old) who completed at least a three-year follow-up in French expert centers were included. Clinical information at presentation and outcome in adulthood were studied. (3) Results: A total of 52 patients were included (34 prospectively in childhood and 18 retrospectively in adulthood), with a mean age of 12 (±2.7) at diagnosis. The median duration time of follow-up was 11.5 years (range 3–44.5). Relapses mostly occurred during treatment decrease (84.5%), others within the three years after treatment interruption (9.1%), and rarely when the disease was stable for more than three years (6.4%). Sarcoidosis was severe in 11 (21.2%) in adulthood. Patients received a high corticosteroid cumulative dose (median 17,900 mg) for a median duration of five years (range 0–32), resulting in mostly mild (18; 35.3%) and rarely severe (2; 3.8%) adverse events. (4) Conclusions: Pediatric-onset sarcoidosis needed a long-term treatment in almost half of the patients. Around one fifth of pediatric-onset sarcoidosis patients had severe sarcoidosis consequences in adulthood.</jats:p>

Sarcoidosis in a Toddler: A Rare Presentation

“…Sarcoidosis is a very rare disease, that has different clinical picture and organ involvement according to age at presentation. The child we describe proves that sarcoidosis in early childhood is not limited to the triad of Blau syndrome; namely: uveitis, arthritis and rash, and the clinical spectrum of sarcoidosis might be variable (6). There are a few studies that aim to describe age or severity related presentations.…”

The Overlap of Kidney Failure in Extrapulmonary Sarcoidosis in Children—Case Report and Review of Literature

“…Recent studies involving adult patients have suggested that serum levels of soluble interleukin-2 receptor (sIL-2r) represent a superior and more sensitive biomarker than serum ACE levels in supporting the diagnosis of systemic sarcoidosis [ 37 , 38 ]. It seems that the level of sIL-2r correlates with the level of disease activity and may indicate multisystem involvement [ 39 ]. However, most studies of sarcoidosis biomarkers have been conducted only among adult patients.…”

“…In a series of 52 patients (34 followed prospectively from childhood and 18 retrospectively in adulthood), Chauveau et al, found that the age at onset was 12 (±2.7), and the relapses occurred mainly during the de-escalation of therapy or in the first three years after the interruption of the treatment; rarely is the disease in remission for more than three years. Sarcoidosis was more severe in adulthood [ 39 ].…”

Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study

“…e, il/elle a été gardé-e à l'extérieur de son domicile, passez à TR 31 10=1), sans activités hors école hors domicile (TR 11=2), passez à AES 1 Si TR 7=2, 3 (le logement occupé aujourd'hui n'est pas celui où est survenue la sarcoïdose) et au moins une fois [TR 29(1,5,6,7,8)=oui ou TR 29(2,3, 4)=non] TR 30 -[…”