Child and adolescent externalizing behavior and cannabis use disorders in early adulthood: An Australian prospective birth cohort study

“…The links between early psychopathology and AUD remain to be identified. The stability of psychopathology into adolescence may play a role here (Dubow et al 2008 ;Hayatbakhsh et al 2008).…”

Section: Earlier Pmd Onsetmentioning

confidence: 99%

The role of mental disorders in the risk and speed of transition to alcohol use disorders among community youth

Behrendt¹,

Beesdo‐Baum²,

Zimmermann

et al. 2010

Psychol. Med.

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Background. Among adolescents and young adults with DSM-IV alcohol use disorders (AUDs), there are interindividual differences in the speed of transition from initial alcohol use (AU) to AUD. AUDs are highly co-morbid with other mental disorders. The factors associated with rapid transition from first AU to AUD remain unknown and the role of mental disorders in rapid transitions is unclear. Given this background we examined (1) whether prior anxiety, mood, externalizing and non-alcohol substance use disorders are related to the risk and speed of transition from first AU to DSM-IV alcohol abuse (AA) and alcohol dependence (AD) and (2) whether early age of onset of prior mental disorders (PMDs) is a promoter of rapid transition.Method. A total of 3021 community subjects (97.7 % lifetime AU) aged 14-24 years at baseline were followed up prospectively for up to 10 years. AU and mental disorders were assessed with the DSM-IV/M-CIDI.Results. Among subjects with lifetime AU, several PMDs, such as specific phobia, bipolar disorder and nicotine dependence, were associated with an increased risk of AUD independent of externalizing disorders. Associations of PMDs with the speed of transition to AUDs were mostly weak and inconsistent. Only social phobia and externalizing disorders were associated with faster transitions to AD even after adjustment for other PMDs. Earlier age of onset of PMD was not associated with rapid transition.Conclusions. Mental disorders are associated with the risk of AUD. With the possible exception of social phobia and externalizing disorders, they do not promote rapid transition, even if they occur particularly early. Future research needs to identify factors relevant to rapid transition to AUD.

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“…Maternal alcohol use during pregnancy has been reported as a significant predictor of adolescent substance use [12] and externalizing behavior [7,13]. It is possible that mothers who smoke during pregnancy also drink [14].…”

Section: Introductionmentioning

confidence: 99%

Maternal cigarette smoking during pregnancy predicts drug use via externalizing behavior in two community‐based samples of adolescents

Lotfipour¹,

Ferguson

Leonard

et al. 2014

Addiction

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Maternal cigarette smoking during pregnancy predicts drug use via externalizing behavior in two community-based samples of adolescents ABSTRACTBackground and Aims Prenatal exposure to maternal cigarette smoking (PEMCS) is associated with a higher probability of substance use in adolescence. We explore if externalizing behavior mediates this relationship, while controlling for a number of potential covariates of this mediation process. Methods We used data obtained in two geographically distinct community samples of adolescents. The first (cross-sectional) sample consisted of 996 adolescents (12-18 years of age) recruited from the Saguenay Youth Study (SYS) in Canada (47% with PEMCS). The second (longitudinal) sample consisted of 1141 adolescents (49% with PEMCS) from the Northern Finland Birth Cohort (NFBC1986). In both samples, externalizing behavior and substance use were assessed during adolescence. In the NFBC1986 cohort, externalizing behavior was also assessed in childhood. Results In both populations, PEMCS is associated with a higher likelihood of adolescent drug experimentation. In the NFBC1986 cohort, exposed (versus non-exposed) adolescents experiment with an extra 1.27 [B = 0.24, 95% confidence intervals (CI) = 0.15, 0.33 P < 0.001] drugs. In the SYS cohort, a clear protective effect of not being exposed is shown: non-exposed (versus exposed) adolescents are 1.5 times [B = −0.42, 95% CI = −0.75, −0.09, P = 0.013] less likely to take drugs. These associations between PEMCS and drug experimentation remain in the multivariate and mediational analyses. Conclusions Prenatal exposure to maternal cigarette smoking appears to be associated with a higher probability of experimenting with drugs during adolescence, both directly and indirectly via externalizing behavior and the number of peers reported as using drugs.

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Child and adolescent externalizing behavior and cannabis use disorders in early adulthood: An Australian prospective birth cohort study

Cited by 54 publications

References 46 publications

Conduct problems trajectories and psychosocial outcomes: a systematic review and meta-analysis

Conduct problems trajectories and psychosocial outcomes: a systematic review and meta-analysis

The role of mental disorders in the risk and speed of transition to alcohol use disorders among community youth

Maternal cigarette smoking during pregnancy predicts drug use via externalizing behavior in two community‐based samples of adolescents

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