Background Around 15–30% of adolescents and young adults (AYAs) suffer from persistent or chronic pain. Strategies to manage pain in different populations have been well described; however, pain is an increasing problem among AYAs, and the use of over-the-counter medications is increasing. The aim of this study was to identify and synthesize evidence from qualitative primary studies on how AYAs in a nonclinical population experience living with persistent pain.Method A qualitative metasynthesis guided by Sandelowski and Barroso’s guidelines was used to synthesize the included studies. The electronic databases Medline, Embase, Cinahl, Psycinfo, Mednar, and ProQuest were searched for studies published in English or Nordic languages from January 2005 to April 2019. Inclusion criteria were adolescents aged 13–18 and young adults aged 19–24 with first-hand experience of living with persistent, recurrent, or episodic nonclinical pain in any body site. Pain associated with a medical diagnosis, malignant diseases, medical procedures or testing, or sport activities was excluded.Results Of 2254 screened records, nine studies including 184 participants (127 female and 57 male aged 11–28 years) with pain from a nonclinical population were analyzed into metasummaries and a metasynthesis. In five of the nine studies, headache was the focused pain condition, while three of the studies did not specify the type of pain. All studies were conducted in a Western cultural context. The metasynthesis revealed that the participants’ experiences were characterized by three themes: 1) juggling pain with everyday life; 2) exploring sources of information to manage pain; and 3) striving to find relief.Conclusion These AYAs experienced a need to juggle dealing with pain with everyday life and explored information on how to manage pain from various sources. Their management of pain was influenced by family norms, and they described how they were striving to find relief from pain.