Child hospitalization due to severe malaria is associated with the ICAM-1Kilifi allele but not adherence patterns of Plasmodium falciparum infected red blood cells to ICAM-1

Mwanziva, Charles; Mpina, Maximillian; Balthazary, Sakurani; Mkali, Humphrey; Mbugi, Erasto V.; Mosha, Frank; Chilongola, Jaffu

doi:10.1016/j.actatropica.2010.05.006

Cited by 4 publications

(6 citation statements)

References 34 publications

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“…More recently, the ICAM-1 Kilifi mutation was shown to be significantly associated with child hospitalisation in Tanzania supporting the link between this mutation with malaria severity, but independent from the cytoadherence pattern of iRBCs on ICAM-1, which can also depend on binding of these isolates to other receptors rather than ICAM-1 in these [ 49 ].…”

Section: Discussionmentioning

confidence: 97%

“…This model is based on an established equilibrium between polymorphism frequency in human and that of parasite strains due to competition between strains preferring binding on either ICAM-1 Kilifi or ICAM-1 ref , the change in host in allele frequency will favor the expansion of the corresponding high binding parasite strains which will select in return against the most frequent allele in host bringing the system to equilibrium at which all individuals will have the same risk of developing severe or cerebral malaria irrespective of their ICAM-1 genotype [ 38 ]. The ICAM-1 Kilifi mutation was also linked to the protection from highly prevalent non-malarial febrile illness in sub-Saharan Africa such as sepsis, suggesting that this polymorphism play a role in the modulation of inflammatory response to pathogens by ICAM-1 and may subsequently explain the high frequency of this polymorphism within African populations [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

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ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children

Blankson

Dadjé

Traikia

et al. 2022

Malar J

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Background Cytoadhesion and sequestration of Plasmodium falciparum infected red blood cells (iRBC) in the microvasculature of vital organs are a major cause of malaria pathology. Several studies have provided evidence on the implication of the human host intercellular adhesion molecule-1 (ICAM-1) as a major receptor for iRBCs binding to P. falciparum erythrocyte membrane protein 1 (PfEMP1) in the development of severe and cerebral malaria. The genetic polymorphism K29M in the immunoglobulin-like domain of ICAM-1, known as ICAM-1Kilifi, has been associated with either increased or decreased risk of developing cerebral malaria. Methods To provide more conclusive results, the genetic polymorphism of ICAM-1Kilifi was assessed by PCR and sequencing in blood samples from 215 Beninese children who presented with either mild or severe malaria including cerebral malaria. Results and conclusions The results showed that in this cohort of Beninese children, the ICAM-1kilifi variant is present at the frequencies of 0.27, similar to the frequency observed in other African countries. This ICAM-1kilifi variant was not associated with disease severity in agreement with other findings from the Gambia, Tanzania, Malawi, Gabon, and Thailand, suggesting no evidence of a direct link between this polymorphism and the pathogenesis of severe and cerebral malaria.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children

Blankson

Dadjé

Traikia

et al. 2022

Malar J

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“…[ 192 ] Increased ICAM‐1 is associated with all these infectious diseases. The Kilifi (rs5491) polymorphism is an A to T allele change at position 179, this results in a methionine to lysine amino acid change which may affect the function of the protein, [ 193 ] and result in an altered response to disease.…”

Section: Inclusion and Exclusion Criteria For Selected Genes And Snpsmentioning

confidence: 99%

“…This could be due to the genetic variation selection of population genetics. [ 193 ] The Kilifi polymorphism may play a similar role in TB, HIV, malaria, and COVID‐19. This polymorphism should be investigated in greater detail.…”

Section: Inclusion and Exclusion Criteria For Selected Genes And Snpsmentioning

confidence: 99%

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Host Genetic Impact on Infectious Diseases among Different Ethnic Groups

Naidoo,

Arumugam,

Ramsuran

2023

Advanced Genetics

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Infectious diseases such as malaria, tuberculosis (TB), human immunodeficiency virus (HIV), and the coronavirus disease of 2019 (COVID‐19) are problematic globally, with high prevalence particularly in Africa, attributing to most of the death rates. There have been immense efforts toward developing effective preventative and therapeutic strategies for these pathogens globally, however, some remain uncured. Disease susceptibility and progression for malaria, TB, HIV, and COVID‐19 vary among individuals and are attributed to precautionary measures, environment, host, and pathogen genetics. While studying individuals with similar attributes, it is suggested that host genetics contributes to most of an individual's susceptibility to disease. Several host genes are identified to associate with these pathogens. Interestingly, many of these genes and polymorphisms are common across diseases. This paper analyzes genes and genetic variations within host genes associated with HIV, TB, malaria, and COVID‐19 among different ethnic groups. The differences in host–pathogen interaction among these groups, particularly of Caucasian and African descent, and which gene polymorphisms are prevalent in an African population that possesses protection or risk to disease are reviewed. The information in this review could potentially help develop personalized treatment that could effectively combat the high disease burden in Africa.

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Intercellular Adhesion Molecule-1 Polymorphisms

Qidwai

2021

Exploration of Host Genetic Factors Associated With Malaria

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Child hospitalization due to severe malaria is associated with the ICAM-1Kilifi allele but not adherence patterns of Plasmodium falciparum infected red blood cells to ICAM-1

Cited by 4 publications

References 34 publications

ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children

ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children

Host Genetic Impact on Infectious Diseases among Different Ethnic Groups

Intercellular Adhesion Molecule-1 Polymorphisms

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