Child maltreatment and depression: A meta-analysis of studies using the Childhood Trauma Questionnaire

Humphreys, Kathryn L.; LeMoult, Joelle; Wear, John G.; Piersiak, Hannah A.; Lee, Aaron; Gotlib, Ian H.

doi:10.1016/j.chiabu.2020.104361

Cited by 349 publications

(232 citation statements)

References 208 publications

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“…Meta-analytic and epidemiological evidence has shown that maltreatment experienced during childhood is significantly associated with depression in adolescents (McLaughlin et al, 2012;Humphreys et al, 2020;LeMoult et al, 2020), consistent with the formulation that adversity experienced during sensitive periods of development has an outsized effect on subsequent neurodevelopmental trajectories supporting mental health (Nelson and Gabard-Durnam, 2020). To measure adversity experienced during childhood, we will use the Childhood Trauma Questionnaire Short Form (CTQ-SF) (Bernstein et al, 2003), which is one of the most widely used measures of childhood maltreatment.…”

Section: Childhood Trauma Questionnairementioning

confidence: 79%

Study Protocol for Teen Inflammation Glutamate Emotion Research (TIGER)

Walker

Teresi

Weisenburger

et al. 2020

Front. Hum. Neurosci.

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This article provides an overview of the study protocol for the Teen Inflammation Glutamate Emotion Research (TIGER) project, a longitudinal study in which we plan to recruit 60 depressed adolescents (ages 13-18 years) and 30 psychiatrically healthy controls in order to examine the inflammatory and glutamatergic pathways that contribute to the recurrence of depression in adolescents. TIGER is the first study to examine the effects of peripheral inflammation on neurodevelopmental trajectories by assessing changes in cortical glutamate in depressed adolescents. Here, we describe the scientific rationale, design, and methods for the TIGER project. This article is intended to serve as an introduction to this project and to provide details for investigators who may be seeking to replicate or extend these methods for other related research endeavors.

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Section: Childhood Trauma Questionnairementioning

confidence: 79%

Study Protocol for Teen Inflammation Glutamate Emotion Research (TIGER)

Walker

Teresi

Weisenburger

et al. 2020

Front. Hum. Neurosci.

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“…A biological basis for MDD risk is strongly supported by genetic studies demonstrating moderate heritability (ranging from about 37% and 45%) (5)(6)(7)(8)(9). Thus, gene-environment interactions are likely crucial to disease etiology, such as stressful life events (10,11), childhood maltreatment (including emotional abuse, sexual abuse, emotional neglect, and physical neglect) (12,13), and in fact these interactions result in an underestimation of the overall genetic influence (14). Kendler et al reported a genetic correlation for liability to major depression of 0.63 in both males and females (9), and a similar estimate was reported in a populationbased twin study (0.55) (15), consistent with several earlier studies suggesting that genetic risk factors are not sex-specific (16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder

Shao

Zhu

2020

Front. Psychiatry

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Major depressive disorder (MDD) is a complex psychiatric disease requiring multidisciplinary approaches to identify specific risk factors and establish more efficacious treatment strategies. Although the etiology and pathophysiology of MDD are not clear until these days, it is acknowledged that they are almost certainly multifactorial and comprehensive. Monoamine neurotransmitter system dysfunction and specific personality traits are independent risk factors for depression and suicide. These factors also demonstrate complex interactions that influence MDD pathogenesis and symptom expression. In this review, we assess these relationships with the aim of providing a reference for the development of precision medicine.

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“…[11][12][13] Its findings suggest that greater attention to type of maltreatment experiences may be helpful for identifying those most at risk for particular negative outcomes, as well as helping to advance our understanding of mechanisms of risk. 13,14 The drive to link specific types of child experiences to distinct outcomes of interest is challenged by the reality that experiences of maltreatment tend to be multidimensional. Despite many clinical decisions about child maltreatment exposure being binary (e.g., above or below threshold), experiences of maltreatment are likely better captured along a continuum.…”

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confidence: 99%

Population-based estimates of associations between child maltreatment type: A meta-analysis

Matsumoto¹,

Piersiak²,

Letterie³

et al. 2020

Preprint

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Context: There is growing interest in better understanding the specificity and magnitude of associations between child maltreatment types in the general population. Objective: To investigate patterns of covariation between child maltreatment types by meta-analyzing studies that assessed experiences of maltreatment using the Childhood Trauma Questionnaire (CTQ) in population-representative samples. Data Sources: A systematic review of studies available on PubMed, PsycINFO, and Google Scholar was conducted. The bibliographies of studies identified were assessed using forward and backward searching.Study Selection: Included studies used the CTQ, a population-representative sample, and had available data to calculate effect sizes. Data Extraction: Data were converted from pearson correlations to Z statitics, and pooled using a random-effects model.Results: All maltreatment types were positively and significantly associated with one another. Effect size estimates varied from medium to large effects, with (1) physical abuse and emotional abuse (Z = 0.72, 95% CI [.48, .96]); (2) physical neglect and emotional neglect (Z = 0.62, 95% CI [0.43, 0.81]); and (3) emotional abuse and emotional neglect (Z = 0.54, 95% CI [0.35, 0.72]) demonstrating the strongest associations. Limitations: Limitations include the relatively few number of studies included, exclusion of other types of adversity, and those associated with the CTQ—a retrospective, self-report measure that does not account for the concurrence of experiences.Conclusions: These analyses provide important evidence of the associations between types of child maltreatment. The pattern of associations indicate the likelihood of shared risk and point to potential characteristics that may link different types of maltreatment.

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Child maltreatment and depression: A meta-analysis of studies using the Childhood Trauma Questionnaire

Cited by 349 publications

References 208 publications

Study Protocol for Teen Inflammation Glutamate Emotion Research (TIGER)

Study Protocol for Teen Inflammation Glutamate Emotion Research (TIGER)

Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder

Population-based estimates of associations between child maltreatment type: A meta-analysis

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