Child maltreatment and the development of psychopathology: The role of developmental timing and chronicity

Russotti, Justin; Warmingham, Jennifer M.; Duprey, Erinn B.; Handley, Elizabeth D.; Manly, Jody Todd; Rogosch, Fred A.; Cicchetti, Dante

doi:10.1016/j.chiabu.2021.105215

Cited by 78 publications

(47 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Differences in developmental timing (which refers to when CM occurs in relation to critical and sensitive periods of the nervous system and body development [ 23 , 24 ]) have been linked to different brain structural volume [ 25 ], physiological and cognitive outcomes [ 26 , 27 ]. CM experiences that span several developmental periods, including both early and later childhood stages, predict a cascade of internalizing and externalizing symptoms in childhood that eventuate in greater symptoms of anxiety, depression, substance use disorder, and antisocial personality disorder in emerging adulthood [ 28 ].…”

Section: Effects Of CM On Mental and Physical Healthmentioning

confidence: 99%

Social Functioning in Individuals Affected by Childhood Maltreatment: Establishing a Research Agenda to Inform Interventions

Pfaltz

Halligan

Haim-Nachum

et al. 2022

Psychother Psychosom

View full text Add to dashboard Cite

Childhood maltreatment (CM) is linked to impairments in various domains of social functioning. Here, we argue that it is critical to identify factors that underlie impaired social functioning as well as processes that mediate the beneficial health effects of positive relationships in individuals exposed to CM. Key research recommendations are presented, focusing on: (1) identifying attachment-related alterations in specific inter- and intrapersonal processes (e.g., regulation of closeness and distance) that underlie problems in broader domains of social functioning (e.g., lack of perceived social support) in individuals affected by CM; (2) identifying internal (e.g., current emotional state) and external situational factors (e.g., cultural factors, presence of close others) that modulate alterations in specific social processes; and (3) identifying mechanisms that explain the positive health effects of intact social functioning. Methodological recommendations include: (1) assessing social processes through interactive and (close to) real-life assessments inside and outside the laboratory; (2) adopting an interdisciplinary, lifespan perspective to assess social processes, using multi-method assessments; (3) establishing global research collaborations to account for cultural influences on social processes and enable replications across laboratories and countries. The proposed line of research will contribute to globally develop and refine interventions that prevent CM and further positive relationships, which – likely through buffering the effects of chronic stress and corresponding allostatic load – foster resilience and improve mental and physical health, thereby reducing personal suffering and the societal and economic costs of CM and its consequences. Interventions targeting euthymia and psychological well-being are promising therapeutic concepts in this context.

show abstract

Section: Effects Of CM On Mental and Physical Healthmentioning

confidence: 99%

Social Functioning in Individuals Affected by Childhood Maltreatment: Establishing a Research Agenda to Inform Interventions

Pfaltz

Halligan

Haim-Nachum

et al. 2022

Psychother Psychosom

View full text Add to dashboard Cite

show abstract

“…Although our sample size did not allow us to explore the differential impact of early life adversity type and timing on the relationships among depression and anxiety with current anger, our findings align with relevant recent studies. Civilian studies have shown that type and timing of early life adversity strongly relate with depressive and anxiety symptoms rather than those of PTSD (Russotti et al, 2021; Schalinski et al, 2016). Studies also have linked types of early life adversity, particularly those aligned with physical neglect, with depressive symptoms and mediated by reward processing, although PTSD was not considered within the model (Dennison et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Associations among clinical variables and anger differ by early life adversity among post‐9/11 veterans

Etchin

Corbo

Brown

et al. 2022

Clin Psychology and Psychoth

View full text Add to dashboard Cite

Maladaptive anger and aggression are common in US military veterans and increase risk for impaired social relationships and functioning, justice-involvement and violence. Early life (before age 18) adversity predisposes veterans to later life psychopathology, though the link to increased later life anger is unclear. We analysed crosssectional data of 158 post-9/11 veterans from the Translational Research Center for Traumatic Brain Injury and Stress Disorders study with and without a history of early life adversity (ns = 109 and 49, respectively). We explored the relationship among major clinical variables and current veteran anger (Dimensions of Anger Reactions) and whether the associations with these variables differed among participants with and without a history of retrospective self-reported early life adversity (Childhood Trauma Questionnaire). In the overall sample, posttraumatic stress disorder (PTSD) and depression severities had the strongest associations with current veteran anger (βs = 0.261 and 0.263; p-values = 0.0022 and 0.0103, respectively). In the subsample without early life adversity, only PTSD severity was significantly associated with anger (β = 0.577, p = 0.0004). In the early life adversity subsample, this strong association weakened and was no longer significant (β = 0.168, p = 0.1007); instead, anxiety and depression severities showed moderate associations with anger (βs = 0.243 and 0.287, p-values = 0.0274 and 0.0130, respectively). Findings suggest that clinicians should screen veterans with history of early life adversity for depression and anxiety when anger is present.

show abstract

“…Since then, more than fifty studies have been conducted to replicate this finding, however, not all of them have achieved their aims[ 11 ]. G×E has been suggested to predict MDD in individuals exposed to negative environmental factors[ 12 , 13 ]. Similarly, many studies have found that a functional SNP within FKBP5 interacted with environments to predict MDD[ 14 - 17 ].…”

Section: Genetic Vulnerability Risk Factors For Mddmentioning

confidence: 99%

Gene × environment interaction in major depressive disorder

Zhao¹,

Song²,

Ma³

2021

WJCC

View full text Add to dashboard Cite

Major depressive disorder (MDD) is a multifactorial disorder, where multiple susceptibility genes interact with environmental factors, predisposing individuals to the development of the illness. In this article, we reviewed different gene × environment interaction (G×E) studies shifting from a candidate gene to a genome-wide approach. Among environmental factors, childhood adversities and stressful life events have been suggested to exert crucial impacts on MDD. Importantly, the diathesis-stress conceptualization of G×E has been challenged by the differential susceptibility theory. Finally, we summarized several limitations of G×E studies and suggested how future G×E studies might reveal complex interactions between genes and environments in MDD.

show abstract

Child maltreatment and the development of psychopathology: The role of developmental timing and chronicity

Cited by 78 publications

References 67 publications

Social Functioning in Individuals Affected by Childhood Maltreatment: Establishing a Research Agenda to Inform Interventions

Social Functioning in Individuals Affected by Childhood Maltreatment: Establishing a Research Agenda to Inform Interventions

Associations among clinical variables and anger differ by early life adversity among post‐9/11 veterans

Gene × environment interaction in major depressive disorder

Contact Info

Product

Resources

About