In order to save children's lives, it is important to consider prevention of child homicide. Opportunities for prevention of neonaticide include increased access to sexual education, abortion, and prenatal care; vigilance of healthcare providers to risk factors, particularly lack of involvement in prenatal care; and engagement of psychiatric and social services when indicated. Safe Havens, baby boxes, and anonymous delivery may save lives. Regarding the killing of older infants, children, and adolescents, consideration of the motive is critical for prevention. Parental social support, parenting education, intervention in abuse and neglect cases, and provision of psychiatric services can help decrease risk. Further research is needed regarding effectiveness of preventive strategies.