The aim of the study was to determine the correlation between care burden and physical activity, quality of life, and sleep quality of mothers with disabled children. Design and Methods: The study was conducted with 165 mothers in a private rehabilitation center. Findings: There was a significant correlation between care burden and quality of life and sleep quality among mothers with disabled children. Practice Implications: It is necessary for nurses to consult parents in terms of social support and to provide psychological support for families with disabled children to reduce the care burden of parents. K E Y W O R D S care burden, disabled child, physical activity, quality of life, sleep quality 1 | INTRODUCTION Finding out that your child is disabled is a traumatic event for the family no matter what the degree of disability could be. However, a disabled child is dependent on his/her parents at varying degrees due to certain developmental aspects, developmental disabilities, and behavioral problems. 1,2 It has been emphasized that disabled children cannot fulfill their daily life activities (nourishment, dressing, going to the toilet, walking, etc) and cause a physical and psychological burden on their parents. 3 A caregiver is defined as the person who takes care of an individual with inadequate skills to perform daily activities due to a physical or mental disorder (Karahan & İslam, 2013). 4 Caregivers give a multifaceted response to the physical, psychological, emotional, social, and financial care-related stressors. This response is defined as the care burden. Caregivers who give care to disabled children encounter significant social, physical, and emotional burdens. 3,5 A disabled child has more impact on the mother. Mothers who are responsible for the care of their disabled children and thus have the care burden experience and impairment in health status due to increased chronic stress, anxiety, depression, hopelessness, chronic fatigue, headache, muscle pain, chronic back pain, difficulty in con