Child-Pugh, MELD, and ALBI scores for predicting the in-hospital mortality in cirrhotic patients with acute-on-chronic liver failure

Peng, Ying; Qi, Xingshun; Tang, Shanhong; Deng, Han; Li, Jing; Zheng, Ning; Dai, Junna; Hou, Feifei; Zhao, Jichun; Wang, Ran; Guo, Xiaozhong

doi:10.1080/17474124.2016.1177788

Cited by 52 publications

(63 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the assessment of liver function in patients with liver cancer and treated with sorafenib, the resolution of the ALBI score is similar to that of the CTP score for patients with a CTP grade of A, whereas the ALBI grading is superior to the CTP grading for all HCC patients (21). The ALBI score has a predictive efficacy similar to that of the CTP and MELD scores in terms of predicting in-hospital mortality in LC patients with acute upper gastrointestinal bleeding and in ACLF patients with concurrent LC (22,24). In the present study, the ALBI score was compared with the CTP and MELD scores to assess their value in evaluating the liver function of patients with HBV-ACLF, HBV-LC, or HBV-HCC.…”

Section: Discussionmentioning

confidence: 57%

Value of the albumin‑bilirubin score in the evaluation of hepatitis B virus‑related acute‑on‑chronic liver failure, liver cirrhosis, and hepatocellular carcinoma

et al. 2018

View full text Add to dashboard Cite

Abstract. The aim of the present study was to investigate the value of the albumin-bilirubin (ALBI) score in the assessment of the disease conditions of hepatitis B virus (HBV)-related acute-on-chronic liver failure (HBV-ACLF), HBV-related liver cirrhosis (HBV-LC) and HBV-related hepatocellular carcinoma (HBV-HCC). A total of 395 patients with HBV-ACLF, HBV-LC, or HBV-HCC were retrospectively studied. The ALBI, Child-Turcotte-Pugh (CTP), and Model for End-Stage Liver Disease (MELD) scores of the patients were calculated, and the relationships between the ALBI score and the CTP and MELD scores were investigated. Furthermore, the ALBI grading was tested for the evaluation of the severity and stages of HBV-ACLF, HBV-LC, and HBV-HCC, especially when classifying the clinical stages of HBV-ACLF. The mean ALBI scores of the HBV-ACLF, HBV-LC, and HBV-HCC patients were -1.17±0.55, -1.76±0.66 and -2.59±0.62, respectively; the mean CTP scores were 10.70±1. 81, 8.19±1.25 and 5.81±1.22, respectively; and the mean MELD scores were 19.93±7.44, 11.10±4.39 and 7.01±3.22, respectively. The ALBI scores were positively correlated with the CTP and MELD scores. The mean ALBI score and the frequency of grade 3 disease were higher in HBV-ACLF patients than in patients with HBV-LC or HBV-HCC. A later HBV-ACLF stage resulted in a higher frequency of ALBI grades of 3. In conclusion, ALBI scores exhibited parallel tendencies to the CTP and MELD scores in HBV-ACLF, HBV-LC, and HBV-HCC patients; thus, ALBI grading may be a simple but applicable method for the evaluation of the functional status of patients with HBV-related end-stage liver diseases.

show abstract

Section: Discussionmentioning

confidence: 57%

Value of the albumin‑bilirubin score in the evaluation of hepatitis B virus‑related acute‑on‑chronic liver failure, liver cirrhosis, and hepatocellular carcinoma

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The ALBI score was developed to assess liver function Cellular Physiology and Biochemistry Cellular Physiology and Biochemistry in patients with hepatocellular carcinoma [18]. However, the ALBI score did not perform satisfactorily in terms of predictive ability in patients with ACLF in a previous study [31]. In the present study, we also analyzed the prognostic value of ALBI score in ACLF and found that it was inferior to that of the ABIC score and that of the MELD score.…”

Section: Discussionmentioning

confidence: 78%

Predictive Value of Age-Bilirubin-International Normalized Ratio-Creatinine Score in Short-Term Survival of Acute-on-Chronic Hepatitis B Liver Failure

Chen

Zheng

Cai

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: The age-bilirubin-international normalized ratio-creatinine (ABIC) score, which is a predictive model commonly used for alcoholic hepatitis, has not yet been studied in acute-on-chronic hepatitis B liver failure (HBV-ACLF). We aimed to investigate the predictive value of the ABIC score in patients with HBV-ACLF. Methods: This retrospective study involved 398 patients diagnosed with HBV-ACLF, who were divided into a training cohort of 305 patients and a validation cohort of 93 patients. Univariate and multivariate Cox regression models were used to determine risk factors for mortality. Area under the receiver operating characteristic curve (AUC) was calculated to estimate and compare the predictive values of different prognostic scores. Results: The ABIC score was significantly higher in the death group of the training cohort than in its survival group. Independent risk factors for mortality identified by multivariate Cox analysis included blood urea nitrogen, ABIC score, and Chronic Liver Failure Consortium Organ Failure (CLIF-C OF) score. For predicting 1- and 3-month mortality, AUC was higher for the ABIC score than for the Model for End-stage Liver Diseases (MELD) score (0.732 vs. 0.653, P < 0.05, 0.695 vs. 0.619, P < 0.05, respectively), CLIF-C OF score (0.693, P=0.353, 0.656, P=0.341, respectively), and Child-Pugh score (0.675, P=0.189, 0.656, P=0.300, Respectively). Patients with ABIC score > 9.44 had reduced 1- and 3-month survival rates. Conclusion: ABIC score is superior to MELD score in predicting short-term survival in HBV-ACLF patients. ABIC score > 9.44 predicts high short-term mortality risk in HBV-ACLF patients.

show abstract

“…) . MELD score was the most commonly used scoring system, which was used in 24 studies (28 cohorts) involving 4663 patients . Followed by CPT score, which was used in 12 studies (16 cohorts) involving 2226 patients .…”

Section: Resultsmentioning

confidence: 99%

“…MELD score was the most commonly used scoring system, which was used in 24 studies (28 cohorts) involving 4663 patients . Followed by CPT score, which was used in 12 studies (16 cohorts) involving 2226 patients . Moreover, eight studies (nine cohorts) involving 1500 patients were included in the analysis of MELD‐Na score .…”

Section: Resultsmentioning

confidence: 99%

Performance of scoring systems to predict mortality of patients with acute‐on‐chronic liver failure: A systematic review and meta‐analysis

Zheng

Zhong

et al. 2017

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

Child-Pugh, MELD, and ALBI scores for predicting the in-hospital mortality in cirrhotic patients with acute-on-chronic liver failure

Abstract: Child-Pugh, MELD, and ALBI scores might be ineffective in predicting the in-hospital mortality of cirrhosis with ACLF.

Cited by 52 publications

References 18 publications

Value of the albumin‑bilirubin score in the evaluation of hepatitis B virus‑related acute‑on‑chronic liver failure, liver cirrhosis, and hepatocellular carcinoma

Value of the albumin‑bilirubin score in the evaluation of hepatitis B virus‑related acute‑on‑chronic liver failure, liver cirrhosis, and hepatocellular carcinoma

Predictive Value of Age-Bilirubin-International Normalized Ratio-Creatinine Score in Short-Term Survival of Acute-on-Chronic Hepatitis B Liver Failure

Performance of scoring systems to predict mortality of patients with acute‐on‐chronic liver failure: A systematic review and meta‐analysis

Contact Info

Product

Resources

About